Management of spontaneous chronic corneal epithelial defects (SCCEDs) in dogs with diamond burr debridement and placement of a bandage contact lens

Gosling, Allyson A.; Labelle, Amber L.; Breaux, Carrie B.

doi:10.1111/j.1463-5224.2012.01026.x

Cited by 45 publications

(100 citation statements)

References 27 publications

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“…48 In these spontaneous superficial chronic corneal erosions, physical methods to disrupt the basement membrane, such as with diamond burr debridement, are required. 49 It would appear that use of CMHA-S can be valuable as a supplement to such ophthalmic treatments but not instead of them.…”

Section: Clinical Experience To Datementioning

confidence: 99%

Ophthalmic Uses of a Thiol-Modified Hyaluronan-Based Hydrogel

Wirostko¹,

Mann

Williams

et al. 2014

Advances in Wound Care

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Section: Clinical Experience To Datementioning

confidence: 99%

Ophthalmic Uses of a Thiol-Modified Hyaluronan-Based Hydrogel

Wirostko¹,

Mann

Williams

et al. 2014

Advances in Wound Care

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“…6 The use of a diamond burr (Fig 7) for debridement and penetration into the stromal layer may also be used successfully to treat these ulcers. 7 Healing of the ulcer takes two to three weeks, but normal adhesion complexes are not formed until at least a year after ulceration. 6 Bandage contact lens use is advocated in many instances to promote healing time and patient comfort.…”

Section: Superficialmentioning

confidence: 99%

Corneal Emergencies

Belknap¹

2015

Topics in Companion Animal Medicine

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“…In this study, the epithelial debridement was performed with a diamond burr unit, used for removing the nonadherent epithelial tissue in the management of spontaneous chronic corneal epithelial defects in dogs and horses. 32,33 Genotype T4 is the most commonly found in the environment and also the cause of AK.…”

Section: Discussionmentioning

confidence: 99%

A Rabbit Model of Acanthamoeba Keratitis: Use of Infected Soft Contact Lenses After Corneal Epithelium Debridement With a Diamond Burr

Ortillés

Goñi

Rubio

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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Citation: OrtillésÁ, Goñi P, Rubio E, et al. A rabbit model of Acanthamoeba keratitis: use of infected soft contact lenses after corneal epithelium debridement with a diamond burr. Invest Ophthalmol Vis Sci. 2017;58:121858: -122758: . DOI:10.1167 PURPOSE. To develop a rabbit model of Acanthamoeba keratitis (AK) as the best method to reproduce the natural course of this disease. METHODS.To induce AK, infected contact lenses (1000 amoebae/mm 2 , 90% trophozoites) were placed over the previously debrided corneal surface, in combination with a temporary tarsorrhaphy. Environmental and clinical strains of Acanthamoeba spp. (genotype T4) were used. Three groups (1L, n ¼ 32; 2L-21d, n ¼ 5; 2L-3d, n ¼ 23) were established according to the number of contact lenses used (1L, 1 lens; 2L-21d and 2L-3d, 2 lenses) and the placement day of these (1L, day 1; 2L-21d, days 1 and 21; 2L-3d, days 1 and 3). The infection was quantified by a clinical score system and confirmed using corneal cytology and culture, polymerase chain reaction and histopathologic analysis.RESULTS. The infection rate obtained was high (1L, 87.5%; 2L-21d, 100%; 2L-3d, 82.6%), although no clinical signs were observed in the 50% of the infected animals in group 1L. Among groups, group 2L-3d showed more cases of moderate and severe infection. Among strains, no statistically significant differences were found in the infection rate. In the control eyes, cross infection was confirmed when a sterile contact lens was placed in the previously debrided corneas but not if the eye remained intact.CONCLUSIONS. The combination of two infected contact lenses after corneal debridement seems to be an alternative model, clinically and histopathologically similar to its human counterpart, to induce the different AK stages and reproduce the course of the disease in rabbits.Keywords: Acanthamoeba, corneal infection, keratitis, animal model, rabbit M ost research about Acanthamoeba keratitis (AK) has been performed in vitro; 1-3 however, the conclusions obtained cannot always be extrapolated to clinical situations. The development, validation and use of an in vivo experimental animal model similar to the course of this disease, is essential for a knowledge improvement of different key aspects, such as its risks factors, the clinical, immunologic, biological, and pathologic characteristics, the diagnostic possibilities, and especially for in vivo testing of new therapeutic agents. 3,4 In vivo AK models have been described using species, such as rabbit, rat, mouse, hamster, cat, and pig (Font RL, et al. IOVS 1981;20:ARVO Abstract 8; Ledbetter EC, et al. IOVS 2012;53:AR-VO E-Abstract 6146). [5][6][7][8][9][10][11][12] To induce AK, intrastromal injection is a fast method to achieve high infection rates but with severe signs and complications, such as endophthalmitis and even death (Font RL, et al. IOVS 1981;20:ARVO Abstract 8). 7,9,[11][12][13][14][15] Other techniques, including subconjunctival injection, irrigation of abraded cornea with parasite-rich inocula, deposition of para...

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Management of spontaneous chronic corneal epithelial defects (SCCEDs) in dogs with diamond burr debridement and placement of a bandage contact lens

Cited by 45 publications

References 27 publications

Ophthalmic Uses of a Thiol-Modified Hyaluronan-Based Hydrogel

Ophthalmic Uses of a Thiol-Modified Hyaluronan-Based Hydrogel

Corneal Emergencies

A Rabbit Model of Acanthamoeba Keratitis: Use of Infected Soft Contact Lenses After Corneal Epithelium Debridement With a Diamond Burr

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