Management of spinal brucellosis and outcome of rehabilitation

K, Nas; Akansel, Gür; Ms, Kemaloğlu; Mf, Geyik; Çevik, Remzi; Büke, Y; Ceviz, Adnan; Aj, Saraç; Aksu, Y

doi:10.1038/sj.sc.3101145

Cited by 44 publications

(37 citation statements)

References 10 publications

(20 reference statements)

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“…Thirty-eight series of patients were traced . Six of these series [9,17,22,23,29,35] were excluded due to patient-overlap with other series. A total number of 870 patients were included in these articles.…”

Section: Resultsmentioning

confidence: 99%

Treatment of brucella spondylitis: lessons from an impossible meta-analysis and initial report of efficacy of a fluoroquinolone-containing regimen

Pappas

Seitaridis

Akritidis

et al. 2004

International Journal of Antimicrobial Agents

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Section: Resultsmentioning

confidence: 99%

Treatment of brucella spondylitis: lessons from an impossible meta-analysis and initial report of efficacy of a fluoroquinolone-containing regimen

Pappas

Seitaridis

Akritidis

et al. 2004

International Journal of Antimicrobial Agents

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“…The treatment duration varies from 6 weeks to 6 months. 1,12 As a conclusion, particularly in endemic regions such as our country, brucellar spondylitis should be kept in mind in the differential diagnosis in elderly patients with back pain and constitutional symptoms. An early diagnosis will prevent the development of more severe complications such as spinal cord compression.…”

Section: Discussionmentioning

confidence: 96%

Brucellar spondylitis: a rare cause of spinal cord compression

et al. 2004

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Study design: A case report. Objectives: To present and discuss some of the difficulties in the diagnosis of brucellar spondylitis. Setting: Ankara University, Ibni Sina Hospital, Turkey. Methods: We report a patient with paraplegia, misdiagnosed as having a malignancy or tuberculosis who actually suffered from brucellar spondylitis. Diagnosis was established by her history and a compatible clinical picture together with a standard tube agglutination (Wright test) titer of X1/160 of antibodies for brucellosis. The patient was treated with oral doxycycline, rifampicin, and ciprofloxacin combination. Results: At the end of the treatment, the blood Brucella Wright and anti-human globulin T titer levels decreased. Her lower limb weakness improved. She could walk, and climb stairs with the help of a cane. Urinary retention and fecal incontinence also resolved. Conclusion: Brucellosis is a systemic infection involving the musculoskeletal and nervous systems. Spondylitis frequently occurs in elderly patients. An early diagnosis of brucellar spondylitis can often be difficult. In endemic regions, as in the case of our country, brucellar spondylitis should always be considered in the differential diagnosis of older patients with back pain and constitutional symptoms. An early diagnosis will help to prevent the development of more severe complications such as spinal cord compression.

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“…Los trastornos del sistema nervioso son complicaciones poco frecuentes (6) , aunque se ha reportado casos de meningitis, abscesos, granulomas (7,8) , y espondilitis (9) . Existen pocos casos publicados de síndrome de Guillain-Barré asociado a Brucelosis (Tabla 1).…”

Section: Discussionunclassified

Síndrome de Guillain Barré asociado a Brucelosis

Montalvo¹,

García²,

Ñavincopa³

et al. 2010

Rev Peru Med Exp Salud Publica

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RESUMENSe describe el caso de un varón de 47 años, con tiempo de enfermedad de dos días, caracterizado por pérdida de fuerza progresiva, simétrica y ascendente de miembros inferiores, se realizó punción lumbar luego de la tomografía cerebral y electromiografía lo cual evidenció polirradiculopatía motora pura con patrón axonal, compatible con el síndrome de Guillain Barré. Posteriormente, recibió cuatro sesiones de plasmaféresis, con mejoría clínica significativa desde la segunda sesión. Debido al antecedente epidemiológico se solicitó set para Brucellas, con rosa de Bengala positivo, se inició tratamiento antibiótico con rifampicina y doxiciclina, además de rehabilitación. Tres meses después el paciente mejoró completamente. La importancia del tratamiento temprano con plasmaféresis y determinar su diagnóstico etiológico hacen que el pronóstico del síndrome de Guillain Barré sea favorable.Palabras clave: Síndrome de Guillain Barré; Brucella; Enfermedades del sistema nervioso periférico (fuente: DeCS BIREME). GUILLAIN BARRÉ SYNDROME IN ASSOCIATION WITH BRUCELLOSIS ABSTRACTWe describe a case of a 47 years old male, with a history of 2 days of progressive, ascendant, symmetrical weakness in the lower extremities; a lumbar puncture was performed after the brain CT scan, as well as an electromyography, evidencing pure motor polyradiculopathy with axonal pattern, compatible with Guillain Barre syndrome. Afterwards, he received four plasmapheresis sessions, with clinical improvement from the second session. Due to his epidemiological background, Brucella set testing was done. Rose Bengal was positive, antibiotic treatment with rifampin and doxicicline was initiated, as well as rehabilitation. Three months later the patient recovered completely. The relevance of early treatment with plasmapheresis and the definition of the etiologic diagnosis determine that the prognosis of the Guillain Barre syndrome is favorable. INTRODUCCIÓNLa Brucelosis es una enfermedad infecciosa producida por cocobacilos Gram negativos aerobios inmóviles del género Brucella, tres especies son las más reconocidas como patógenos (mellitensis, abortus y suis) de las siete que se conocen a la fecha. Posee gran capacidad de sobrevivir en el interior de las células fagocíticas, lo que determina su característica clínica (1) .Las infecciones por Brucella están ocasionadas por la exposición directa o indirecta a los animales infectados (en zona urbana, a la ingesta de productos lácteos no pasteurizadas y, en zona rural, por contacto con animales enfermos). En el Perú se notifica anualmente más de 1000 casos de Brucellosis, la mayoría se deben a la infección por Brucella melitensis por consumo de queso de cabra proveniente de provincias vecinas a Lima.El periodo de incubación varía de una a tres semanas. La enfermedad puede afectar cualquier órgano o sistema y comienza con síntomas inespecíficos y polimorfos, a veces es asintomática. Generalmente se inicia con fiebre, escalofríos, malestar general, hiporexia, cefalea y artromialgias. Entre los sistemas m...

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Management of spinal brucellosis and outcome of rehabilitation

Cited by 44 publications

References 10 publications

Treatment of brucella spondylitis: lessons from an impossible meta-analysis and initial report of efficacy of a fluoroquinolone-containing regimen

Treatment of brucella spondylitis: lessons from an impossible meta-analysis and initial report of efficacy of a fluoroquinolone-containing regimen

Brucellar spondylitis: a rare cause of spinal cord compression

Síndrome de Guillain Barré asociado a Brucelosis

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