Management of severe hypertriglyceridaemia

Cybulska, Barbara; Kłosiewicz−Latoszek, Longina

doi:10.5603/kp.2013.0254

Cited by 6 publications

(7 citation statements)

References 25 publications

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“…The topic of this article is an important practical lipidologic issue, along with familial hypercholesterolaemia and severe hypertriglyceridaemia which have also been recently reviewed in the Polish literature [41,42].…”

Section: Discussionmentioning

confidence: 99%

The HDL paradox: what does it mean and how to manage low serum HDL cholesterol level?

Cybulska

Kłosiewicz−Latoszek

2014

Kardiol Pol

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The topic of this article is an important practical lipidologic issue, along with familial hypercholesterolaemia and severe hypertriglyceridaemia which have also been recently reviewed in the Polish literature. In this paper, we attempted to summarise current scientific evidence and views on the complex role of HDL in atherogenesis, as well as therapeutic recommendations in patients with low HDL-C level. In summary, it should be noted that the available evidence does not indicate that HDL are not antiatherogenic lipoproteins but rather directs our attention towards their functionality and dysfunctionality accompanying numerous pathologic conditions associated with inflammation. It may be hoped that effective methods to increase the number of functional HDL in the plasma will be developed in future studies, translating to a reduction in CV events and thus deserving a place in clinical practice guidelines.

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Section: Discussionmentioning

confidence: 99%

The HDL paradox: what does it mean and how to manage low serum HDL cholesterol level?

Cybulska

Kłosiewicz−Latoszek

2014

Kardiol Pol

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“…Za najbogatsze źródła kwasu erukowego uważa się niektóre gatunki i pokrewne odmiany B. napus, B. rapa, B. carinata, w których omawiany związek stanowi 40 ÷ 50 % ilości wszystkich kwasów tłuszczowych [1]. Z nasion Brassica napus wytwarzany jest jeden z najpopularniejszych olejów jadalnych, czyli olej rzepakowy, zaliczany do najcenniejszych tłuszczów jadalnych ze względu na korzystny dla zdrowia człowieka skład ilościowy i jakościowy kwasów tłuszczowych oraz wysoką zawartość witamin E i K [7]. Do celów spożywczych tłoczy się go z nasion odmian rzepaku o niskiej zawartości kwasu erukowego (ang.…”

Section: Kwas Erukowyunclassified

“…LEARlow erucic acid rapeseed), wynoszącej zwykle poniżej 0,5 % całkowitej ilości kwasów tłuszczowych [14]. Taki rzepak nazywany jest również podwójnie ulepszonym lub dwuzerowym (typ 00), ponieważ nie tylko zawiera znikome ilości kwasu erukowego (maksymalnie 2 %), ale także ma zmniejszoną zawartość glukozynolanów (poniżej 15 µmol/g śruty poekstrakcyjnej) [1,7]. Z kolei olej z odmian rzepaku o wysokiej zawartości kwasu erukowego (ang.…”

Section: Kwas Erukowyunclassified

“…Wyniki badań naukowych przeprowadzonych w latach 70. ubiegłego wieku wykazały, iż kwas erukowy, obecny w dużych ilościach w uprawianych wówczas odmianach rzepaku, stanowił poważne zagrożenie dla zdrowia człowieka [7]. Wyższy poziom kwasu erukowego w fosfolipidach w osoczu powiązano z częstszym występowaniem zastoinowej niewydolności serca w dwóch niezależnych kohortach, podczas gdy wyższe poziomy kwasu erukowego krążącego w erytrocytach powiązano z mniejszą częstością występowania choroby niedokrwiennej serca.…”

Section: Kwas Erukowyunclassified

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Zanieczyszczenia Żywności – Charakterystyka I Regulacje Prawne. Część I – Toksyny Roślinne

GAŁKOWSKA,

PYCIA,

KAPUŚNIAK

et al. 2023

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Food health safety is a set of conditions that must be met and actions that must be taken at all stages of production of or trade in food in order to ensure human health and life.. Food safety is guaranteed by appropriately shaped food law, and the food safety policy pursued by the European Union institutions covers all stages of the food chain, from production to consumption, and guarantees the clarity of infor mation on the origin and composition of food and its labelling. However, not all hazards can be completely eliminated from food, which is why their residues are strictly regulated by law. The key solution in this area was Commission Regulation (EC) No. 1881/2006 of 19 December 2006 setting the maximum levels of certain contaminants in foodstuffs. This legal act, which had been supplemented and amended many times, was replaced by Commission Regulation (EU) 2023/915 of 25 April 2023 on the maximum levels of certain contaminants in food and repealing Regulation (EC) No. 1881/2006. The aim of the work was to characterize plant toxins as contaminants in food, the highest permissible levels of which were introduced by amendments to Regulation EC 1881/2006 and included in the current EU Regulation 915/2023. Results and conclusions: Numerous amendments to Regulation 1881/2006, and consequently Regula tion 2023/915, introduced the highest permissible levels for the following plant toxins: erucic acid, tropane and pyrrolizidine alkaloids and opium alkaloids, hydrogen cyanide and cyanogenic glycosides, and delta 9-tetrahydrocannabinol equivalents. Due to the potential threat of these substances, their highest residues in individual foodstuffs must be regulated and monitored as part of official food control activities, while when obtaining raw materials that may contain this type of substances, it is necessary to follow appropri ate recommendations and good practices.

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“…We hope that our review will contribute to better understanding of the current views of the role of Lp(a) in atherogenesis. This issue, along with the management of familial hypercholesterolaemia [49,50] and severe hypertriglyceridaemia [51,52] and changing views on the importance of HDL-C level in the development and prevention of atherosclerosis [53,54], is one of the hot topics in lipidology. has not been established.…”

Section: Lipoprotein(a)-lowering Therapymentioning

confidence: 99%

What do we know about lipoprotein(a)?

Cybulska

Kłosiewicz−Latoszek²

2015

Kardiol Pol

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gene, rs 10 455 872 and rs 3 798 220, are associated with a low number of KIV-2 copies and an increased Lp(a) level and CVD risk [9]. Thus, plasma Lp(a) levels are mostly determined genetically in relation to LPA gene variability which results in a variable number of KIV-2 copies. ABNORMAL LIPOPROTEIN(A) LEVELS Lp(a) levels vary markedly between subjects and population. In the Copenhagen General Population Study, a typical skewed plasma Lp(a) level distribution was shown, with 80% of the population having levels below 50 mg/dL, and only 20% of the population having levels in the 50-200 mg/dL range [10]. Thus, Lp(a) levels > 50 mg/dL, corresponding to the > 80 th percentile, are considered abnormal and a constitute a clinical biomarker of an increased CVD risk. Lowest Lp(a) levels are seen in non-Hispanic whites, higher in Hispanics, and highest in blacks [11]. Of note, however, most studies and metaanalyses indicate an increased CVD risk with Lp(a) levels as low as > 25-30 mg/dL [5]. LIPOPROTEIN(A) AS A RISK FACTOR Epidemiological evidence confirm an independent association between Lp(a) level and CVD risk, although this relation is weaker that the association between LDL cholesterol (LDL-C) level and CVD risk. The latter is more strongly related to Lp(a) levels in the presence of a high LDL-C level but the risk is observed also in subjects with LDL-C level < 1.8 mmol/L [12]. As elevated Lp(a) level is present since birth, it may potentially contribute to CVD risk already during early life, similarly to other genetic risk factors. According to an early metaanalysis of 18 prospective studies in the general population that included 4,000 coronary artery disease (CAD) cases, the relative risk (RR) of CAD in the upper tertile of Lp(a) level compared to the lowest tertile was 1.7 (95% confidence interval [CI] 1.4-1.9) [4]. In subsequent metaanalyses, this association was more modest. In a metaanalysis of three prospective studies that included 9,870 CAD cases, RR of CAD in a comparison of extreme thirds of Lp(a) levels was 1.5 (95% Cl 1.3-1.8) [13]. The largest

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Management of severe hypertriglyceridaemia

Cited by 6 publications

References 25 publications

The HDL paradox: what does it mean and how to manage low serum HDL cholesterol level?

The HDL paradox: what does it mean and how to manage low serum HDL cholesterol level?

Zanieczyszczenia Żywności – Charakterystyka I Regulacje Prawne. Część I – Toksyny Roślinne

What do we know about lipoprotein(a)?

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