Management of recurrent aphthous stomatitis in children

Montgomery-Cranny, Jodie; Wallace, Ann; Rogers, Helen J.; Hughes, Sophie C; Hegarty, Anne M; Zaitoun, Halla

doi:10.12968/denu.2015.42.6.564

Cited by 32 publications

(19 citation statements)

References 31 publications

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“…In this study, local treatments were used to avoid the bad effects of systemic drugs, this agrees with Puratchikody et al (22) who decided that local drug carriage systems have been commonly de veloped for treatment of oral lesions.…”

Section: Discussionsupporting

confidence: 83%

Effect of Diode Laser combined with Hyaluronic Acid Gel in Treatment of Recurrent Aphthous Stomatitis in Children: Randomized Clinical Trial

Shalaby

2019

Egyptian Dental Journal

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Background: Recurrent Aphthous Stomatitis (RAS) is a painful rounded ulcer characteristic by erythematous margin and pseudo yellowish-gray membrane in its center .All forms of RAS have bad effects on quality of life that interfere with daily activities. Hyaluronic acid has essential part in tissue hydrodynamics, cell migration, proliferation and differentiation. It shows an antiinflammatory role so; it prevents tissue destruction and helps in tissue healing. Low level laser therapy is recognized with various terminologies such as "biostimulator," and "cold laser," It has role in the management of RAS, it has a wide spectrum of clinical applications which include herpes labialis, angular cheilitis, trismus, paresthesia, dentin hypersensitivity, temporomandibular joint pain, and in the postoperative phase. Materials and Method:Forty five normal healthy males and females children aged from (4-10 years) suffering from aphthous lesions were used in this study. Children were examined in Outpatient clinic pediatric Dentistry Department, Faculty of Dentistry, Suez canal University by a clinician. Each patient had one minor RAS of less than 72 h duration or two nearby minor aphthous lesions of less than 72 h at the same side of oral cavity. Patients were evenly divided into three groups (15 patients in each) with the method of simple randomization, Patients of group I were treated with topical application of hyaluronic acid gel , those of group II were treated with diode laser and group III patients were treated with diode laser followed by topical application of hyaluronic acid gel. The patients were evaluated at (0, 2 nd , 4 th and 6 th ) days, for measuring ulcer size and pain score. Results:At the 2 nd , 4 th and 6 th days there was statistical significance decrease in mean size of the ulcer of group III when compared to both groups (I) and (II) . On other hands, at days 2 and 6 there was statistical significance decrease in mean of pain score in group III when compared to group I. There was also statistical significance decrease in mean of pain score in group II when compared to group I at the 4 th day of evaluation. Conclusion:Hyaluronic acid gel combined with diode laser are effective in treatment of RAS.

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Section: Discussionsupporting

confidence: 83%

Effect of Diode Laser combined with Hyaluronic Acid Gel in Treatment of Recurrent Aphthous Stomatitis in Children: Randomized Clinical Trial

Shalaby

2019

Egyptian Dental Journal

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“…There is no established management guideline for RAU, and there are numerous treatment options. No study has assessed the efficacy of the various treatment methods in children (5).…”

Section: Discussionmentioning

confidence: 99%

“…Aphthous ulcers (AU) can negatively impact a child's quality of life by interfering with eating and speaking, and may also result in poor school attendance (5). Vitamin deficiencies, infection, and immunodeficiency are the most common risk factors for AU in children (6,7).…”

Section: Introductionmentioning

confidence: 99%

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Hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children: efficacy and safety analysis

Yang¹,

Lin³

et al. 2020

Braz J Med Biol Res

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The objective of this study was to compare the safety and efficacy of 0.2% hyaluronic acid (HA) topical gel and dexamethasone topical ointment in the treatment of recurrent aphthous ulcers (RAU) in children. This retrospective observational study included 104 patients who had more than two episodes of oral aphthous ulcers per year and were treated with HA (n=52) or dexamethasone (n=52) from August 15, 2014 to September 3, 2018. Therapy efficacy was evaluated based on the ulcer size and pain score before versus 7 days after either therapy. The paired t-test, chi-squared test, and independent t-test were utilized for statistical analyses. There was no significant difference in ulcer size or pain score between the HA and dexamethasone groups, on day 1 or day 7. Both treatments were tolerated well and no side effects were reported. No significant differences in body temperature, respiration rate, pulse, or systolic/diastolic blood pressure were observed between the start (day 1) and end of treatment (day 7), for either treatment. HA and dexamethasone showed similar efficacy in reducing ulcer size and pain scores, and were tolerated equally well in children with RAU. Future high-quality studies with larger numbers of patients are needed to confirm our findings.

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“…It is also associated with 7%–13% relative increases of the prevalence of genital ulcers, ocular or skin involvement, and a 30% relative reduction on the prevalence of gastrointestinal involvement 9. Regardless, in children presenting with oral ulceration, the presence of the HLA-B51/B5 allele should not exclude the possibility of other diseases with similar manifestations, such as nutritional deficiencies 10…”

Section: Discussionmentioning

confidence: 99%

Behçet’s disease presenting as recurrent oral aphthosis in a 9-year-old boy from Greece

et al. 2020

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We report a case of Behçet’s disease in a 9-year-old boy from Greece, presenting with a history of recurrent ulceration of the oral cavity. Following inspection of the oral cavity, which revealed lesions on both the upper and lower labial mucosa, as well as a large ulcer on the apex of the tongue, the diagnosis of Behçet’s disease was immediately suspected. The diagnosis was confirmed using the International Criteria for Behçet’s Disease. Nevertheless, as multiple diseases can cause recurrent oral aphthosis, an extensive differential diagnosis was made, and pertinent tests were undertaken to exclude other causes of oral ulceration. The approach to a patient with Behçet’s disease, as well as its various clinical presentations and complications, is discussed.

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Management of recurrent aphthous stomatitis in children

Cited by 32 publications

References 31 publications

Effect of Diode Laser combined with Hyaluronic Acid Gel in Treatment of Recurrent Aphthous Stomatitis in Children: Randomized Clinical Trial

Effect of Diode Laser combined with Hyaluronic Acid Gel in Treatment of Recurrent Aphthous Stomatitis in Children: Randomized Clinical Trial

Hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children: efficacy and safety analysis

Behçet’s disease presenting as recurrent oral aphthosis in a 9-year-old boy from Greece

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