Management of post-surgical Achilles tendon complications with a preparation rich in growth factors: A study of two-cases

Sánchez, Mikel; Anitua, Eduardo; Cole, A. S.; Silva, Alejandra Da; Azofra, Juan; Andı́a, Isabel

doi:10.1016/j.injury.2008.09.017

Cited by 12 publications

(8 citation statements)

References 25 publications

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“…Studies used various activating agents, including autologous thrombin, 13 calcium chloride, 14,15,18,19 both, 22 and none at all. 11,20 Three studies did not specify the use of activating agents.…”

Section: Resultsmentioning

confidence: 99%

“…The authors retrospectively studied the influence of fibrin matrices prepared from PRP in the repair of Achilles tendon tears in 6 athletes, describing better functional outcomes and an earlier return to training in the PRP group. In another study, they described the use of PRP scaffolds and liquid preparations simultaneously applied in 2 cases of complicated Achilles tendon repair (revision of infected tendon repair with tissue loss), 15 reporting good results with return to sports at an average of 21 weeks (14 weeks to resume football training and 28 weeks to resume climbing) and ultrasound findings of scar tissue filling the site of lesion. In 1 case, the follow-up was 5 years.…”

Section: Achilles Tendinopathy and Tendon Repairmentioning

confidence: 99%

See 1 more Smart Citation

A Systematic Review of the Use of Platelet-Rich Plasma in Sports Medicine as a New Treatment for Tendon and Ligament Injuries

Taylor

Petrera

Hendry

et al. 2011

Clinical Journal of Sport Medicine

207

127

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Section: Resultsmentioning

confidence: 99%

Section: Achilles Tendinopathy and Tendon Repairmentioning

confidence: 99%

A Systematic Review of the Use of Platelet-Rich Plasma in Sports Medicine as a New Treatment for Tendon and Ligament Injuries

Taylor

Petrera

Hendry

et al. 2011

Clinical Journal of Sport Medicine

207

127

View full text Add to dashboard Cite

show abstract

“…They also published two cases where PRP scaffolds and liquid preparations were simultaneously applied in patients with complicated Achilles tendon repair (revision of infected tendon repair with tissue loss). Satisfactory results for return to sports (average of 21 weeks) and ultrasound findings of scar tissue filling the site of lesion were reported (Sánchez et al 2009a). Conversely, results of a randomized controlled single-blind trial compared PRP after their Achilles repair to direct repairs only suggested that PRP is not useful for treatment of Achilles tendon ruptures (Schepull et al 2011).…”

Section: Achilles Tendonmentioning

confidence: 96%

Platelet-Rich Plasma: From Laboratory to the Clinic

et al. 2014

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PRP preparations contain high concentrations of platelets that, once activated, undergo degranulation to release growth factors with healing properties. Due to its autogenous origin, easy preparation, inexpensiveness, and excellent safety profile, the use of PRP technologies has opened a gait to the treatment of soft-tissue injuries. PRP has been increasingly used in sports-related injuries for therapeutic applications. Since sports medicine patients desire earlier return to training and competition, PRP may have certain applications that will speed recovery in cases of tendon, ligament, muscle, and cartilage disorders. There is still an ongoing debate about the positive clinical and experimental outcomes. Despite the lack of hard evidence through randomized clinical trials, clinical observations and opinions suggest that pain relief and return to function occur more rapidly than expected for some healing orthopedic problems after the use of PRP. This chapter will focus on the laboratory studies about the effects of PRP on the most common sports-related injury areas and thus the brief review of the clinical studies.

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“…In one case, an autologous semitendinosus tendon was used to fill the Achilles tendon gap. Before the graft was anchored, we injected PRP liquid into the newly formed tissue (during week 3 after the first operation), among the tendon fibres of the graft and into the reconstructed tendon [27].…”

Section: Management Of Postsurgical Achilles Tendon Complications Witmentioning

confidence: 99%

PRP Injections in Orthopaedic Surgery: Why, When and How to Use PRP Dynamic Liquid Scaffold Injections in Orthopaedic Surgery

Sánchez¹,

Delgado²,

Garate³

et al. 2018

Plasma Medicine - Concepts and Clinical Applications

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Platelet-rich plasma (PRP) products can be described as any autologous blood platelet concentrate within a plasma suspension. PRP products include plasma and twofold or greater increases in platelet concentrations above baseline levels. The injection of activated PRP in its liquid formulation delivers growth factors locally and simultaneously mimics and amplifies the spontaneous healing response in injured areas and in special cell niches, which would otherwise be inaccessible. This in situ generated transient threedimensional scaffold will gradually release growth factors and maintain their concentration at the site of the scaffold formation. The combination of liquid PRP with surgical techniques in orthopaedic surgery allows a wide range of therapeutic strategies in the management of injuries in the field of orthopaedics and sports medicine. The use of different therapeutic elements, including PRP as biological stimuli and rehabilitation and physiotherapy treatments as mechanical stimuli, provides extremely favourable synergies that will help fulfil the physician's objective, to stop the progression of disease and to improve function in the shortest period of time

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Management of post-surgical Achilles tendon complications with a preparation rich in growth factors: A study of two-cases

Cited by 12 publications

References 25 publications

A Systematic Review of the Use of Platelet-Rich Plasma in Sports Medicine as a New Treatment for Tendon and Ligament Injuries

A Systematic Review of the Use of Platelet-Rich Plasma in Sports Medicine as a New Treatment for Tendon and Ligament Injuries

Platelet-Rich Plasma: From Laboratory to the Clinic

PRP Injections in Orthopaedic Surgery: Why, When and How to Use PRP Dynamic Liquid Scaffold Injections in Orthopaedic Surgery

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