Management of paraneoplastic syndromes in lung cancer

Thomas, Leno; Kwok, Young; Edelman, Martin J.

doi:10.1007/s11864-004-0006-6

Cited by 33 publications

(23 citation statements)

References 66 publications

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“…The types of PNSs vary substantially and often develop preceding the diagnosis of primary malignancy [3]. For most PNSs, the best treatment is to treat the underlying malignancy [4]. Here we report a rare case of PNS developed in a late-stage lung cancer patient after one cycle of chemotherapy, which closely resembled the typical manifestations of Adult-Onset Still' s Disease (AOSD).…”

Section: Introductionmentioning

confidence: 93%

Paraneoplastic syndrome mimicking adult-onset Still's disease caused by advanced lung cancer: a case report

et al. 2011

BMC Cancer

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BackgroundParaneoplastic syndromes (PNSs) are common complications of lung cancer and often develop preceding the diagnosis of primary malignancy. Rheumatologic PNSs mimicking Adult-Onset Still' s Disease (AOSD) is a rare condition with only a limited number of cases reported in the literature, none of which was associated with lung cancer. It is often difficult to differentiate AOSD-like paraneoplasia from coincidental AOSD based on the clinical manifestations.Case presentationHere we present a 56-year-old man with advanced lung adenocarcinoma who developed a remittent fever together with pharyngodynia and joint pain after first cycle of chemotherapy with paclitaxel plus carboplatin. Although a leukocytosis was detected, no evidence of infection was acquired and empirical antibiotic treatment was ineffective. A temple skin rash, abnormal hepatic function and a remarkable elevated level of serum ferritin occurred later in this patient, which highly supported a potential diagnosis of AOSD. The patient was finally diagnosed as AOSD-like PNS considering the good and prompt response to a short-term administration of non-steroidal anti-inflammatory drug and subsequent cycles of effective chemotherapy with pemetrexed plus cisplatin.Discussion and conclusionsThough rare, AOSD-like PNS can be one of the potential diagnoses in lung cancer patients with fever of undetermined origin, especially those having no response to antibiotic treatment. Management consists of control of the underlying malignancy and symptomatic treatment of the syndromes with non-steroidal anti-inflammatory drugs or corticosteroids.

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Section: Introductionmentioning

confidence: 93%

Paraneoplastic syndrome mimicking adult-onset Still's disease caused by advanced lung cancer: a case report

et al. 2011

BMC Cancer

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“…Das paraneoplastische Syndrom der inadäquaten Sekretion von antidiuretischem Hormon (SIADH) ist definiert durch folgende Symptome: a) Hyponatriämie, b) Hypoosmolalität des Plasma, c) keine Diuretikaeinnahme, d) kein extrazelluläres Volumendefizit, e) Urinosmolalität größer als Plasmaosmolalität, f) normale Nierenfunktion, g) normale Nebennierenfunktion, h) Euthyreose [1381]. Es tritt gehäuft beim kleinzelligen (klinisch manifest in ca.…”

Section: Hyponatriämieunclassified

Prävention, Diagnostik, Therapie und Nachsorge des Lungenkarzinoms

Goeckenjan¹,

Sitter²,

Thomas

et al. 2010

Pneumologie

122

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“…Although PNSs are rare, the best treatment is to identify and treat the underlying tumor (Thomas, Kwok, & Edelman, 2004). Although PNSs are rare, the best treatment is to identify and treat the underlying tumor (Thomas, Kwok, & Edelman, 2004).…”

Section: Hypercalcemiamentioning

confidence: 99%

Paraneoplastic Syndromes Related to Lung Cancer

McClelland

2010

Clinical Journal of Oncology Nursing

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Paraneoplastic syndromes (PNSs) are defined as signs or symptoms that occur as a result of organ or tissue damage at locations that are remote from the primary tumor site or metastases. Many cancers are associated with PNSs; however, small cell lung cancer (SCLC) is the most prevalent. In SCLC, the systems primarily affected by PNSs include the endocrine system, the neurologic system, and the integumental system. This article provides an overview of primary disorders and classical syndromes, as well as symptom management associated with each system. PNSs are rare, and the best approach is to treat the underlying tumor. Therefore, oncology nurses and other healthcare practitioners should be familiar with PNSs so that they can take prompt and proper courses of action, potentially leading to positive outcomes for patients.

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Management of paraneoplastic syndromes in lung cancer

Cited by 33 publications

References 66 publications

Paraneoplastic syndrome mimicking adult-onset Still's disease caused by advanced lung cancer: a case report

Paraneoplastic syndrome mimicking adult-onset Still's disease caused by advanced lung cancer: a case report

Prävention, Diagnostik, Therapie und Nachsorge des Lungenkarzinoms

Paraneoplastic Syndromes Related to Lung Cancer

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