Management of melanomas of the female genital tract

Sugiyama, Valerie; Chan, John K.; Kapp, Daniel S.

doi:10.1097/cco.0b013e32830b0dda

Cited by 57 publications

(50 citation statements)

References 53 publications

(47 reference statements)

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“…Most vaginal melanomas are diagnosed in the 6th or 7th decade of life in postmenopausal women [5]. The most common symptom of vaginal melanoma is vaginal bleeding, followed by dyspareunia [11,14]. The 5-year survival rate for this very aggressive, rapidly growing tumour is very poor, and is reported to be 0-25 % irrespective of the chosen therapy [10,16].…”

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confidence: 99%

Primary Malignant Vaginal Melanoma - Case Report and Review of the Literature

Kühn

Dieterich

Klar

et al. 2012

Geburtsh Frauenheilk

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With fewer than 250 cases published worldwide, primary vaginal melanoma is an extremely rare malignant entity which is mostly diagnosed in advanced stages. The estimated incidence of vaginal melanoma is 0.026/100?000 women per year. The poor prognosis for advanced tumour stages and different therapies used in very limited numbers of patients require precise preoperative staging and a planned interdisciplinary therapeutic approach.

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confidence: 99%

Primary Malignant Vaginal Melanoma - Case Report and Review of the Literature

Kühn

Dieterich

Klar

et al. 2012

Geburtsh Frauenheilk

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“…The first case of malignant urethral melanoma was reported by Tyrell and Reed more than 100 years ago [6,10]. Malignant urethral melanoma is three times as common in females as in males and is more frequent in the Caucasian population.…”

Section: Discussionmentioning

confidence: 99%

“…These findings are similar to those observed in our previous case of malignant urinary bladder melanoma [8], thus suggesting the utility of measuring the HMB-45 antibody titer for immunohistochemically detecting malignant urogenital melanomas. Malignant urethral melanomas have a worse prognosis than malignant cutaneous melanomas, as lymph node metastasis is usually found at the time of the initial diagnosis and there is a significant delay in diagnosis in such cases [10]. Malignant urethral melanomas frequently presents as polypoid tumors and are mistaken for other malignant diseases and even benign lesions, including urethral polyps, caruncles, mucosal prolapse or chancres [6,15].…”

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confidence: 99%

Primary malignant melanoma of the female urethra: a rare case of cytological observation

Kawaguchi¹,

Nambu²,

Sekiya³

et al. 2014

Pathol Discov

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We herein report a rare case of primary malignant urethral melanoma developed in an elderly Japanese patient with hypertension, diabetes and hyperlipidemia. An 80-year-old female presented at our hospital with a history of urodynia and perineal pain lasting for several months. Cystoscopy revealed cystitis and urethritis with erosion. At that time, urinary cytology was negative for malignancy, although melanophages were observed. Four months later, lower abdominal computed tomography and magnetic resonance imaging indicated urethral tumors. Urinary cytology subsequently detected malignant melanoma, and a biopsy of the urethra confirmed malignancy. Although inguinal lymph node metastasis was found 16 months postoperatively, the patient has remained free of disease for more than six years after surgery and chemotherapy.

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“…The most common symptoms are vaginal bleeding, vaginal discharge and feeling a mass in the vagina. It is mostly localized in the anterior wall in lower one third of the vagina [6,7].…”

Section: Discussionmentioning

confidence: 99%

Primary Melanoma of the Vagina Treated by Imatinib: Case Report

Oualla¹,

Elmrabet²,

Elfatemi³

et al. 2013

JCT

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Melanoma of the vagina is a rare lesion. It results from the malignant transformation of ectopic melanocytes occurring in post-menopause. The CKIT is expressed in 36% of cases in addition to melanoma markers. Prognosis is poor especially for inoperable and disseminated forms despite systemic therapy. Treatment with Imatinib is an option in cases of metastatic mucosal melanoma with CKIT mutation or amplification. We report the case of post-menopausal women, treated at Hassan II University Hospital, diagnosed with metastatic melanoma of the vagina, that didn't respond to first line of chemotherapy, and received Imatinib as second line of treatment, with good clinical response and durable stability at radiological assessment.

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Management of melanomas of the female genital tract

Abstract: The results of treatment for female genital tract melanomas remain poor. Although surgery remains the initial treatment of choice for localized disease, adjuvant local-regional, and systemic therapies are needed.

Cited by 57 publications

References 53 publications

Primary Malignant Vaginal Melanoma - Case Report and Review of the Literature

Primary Malignant Vaginal Melanoma - Case Report and Review of the Literature

Primary malignant melanoma of the female urethra: a rare case of cytological observation

Primary Melanoma of the Vagina Treated by Imatinib: Case Report

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