Management of infections related to totally implantable venous-access ports: challenges and perspectives

Lebeaux, David; Fernández-Hidalgo, Núria; Chauhan, Ashwini; Lee, Samuel; Ghigo, Jean‐Marc; Almirante, Benito; Beloin, Christophe

doi:10.1016/s1473-3099(13)70266-4

Cited by 157 publications

(120 citation statements)

References 145 publications

Supporting

Mentioning

102

Contrasting

Unclassified

Order By: Relevance

“…Clinical demonstration of the presence of persisters can be inferred from the risk of infection recurrence during biofilm-related infections. For instance, in the case of catheter-related bloodstream infection (CRBSI), even after local treatment with high concentrations of antibiotics (up to 1,000-fold higher than the MIC) for 2 weeks, more than 20% of infections relapse because of the survival of persisters inside the biofilm (90). Thus, the currently proposed model to explain biofilm recalcitrance toward antibiotics relies mainly on the presence of persister cells (13,14).…”

Section: Persisters Play a Central Role In Biofilm Recalcitrance Towamentioning

confidence: 99%

“…In cases of uncomplicated LTIVC-related BSI, a conservative treatment can be used based on ALT (90,194). Indeed, if the clinical situation allows, catheter salvage is indicated in cases of reduced venous access or the potential presence of coagulation disorders (194).…”

Section: Currently Used Approaches Do Not Specifically Target Biofilmmentioning

confidence: 99%

“…However, LTIVC removal is mandatory in cases of local or distant complications or in cases of infection caused by S. aureus or Candida spp., based on the high failure rate of treatment when the colonized catheter is retained (241). In other cases, conservative treatment using a combination of systemic antimicrobials and ALT can be considered (90,194). Despite several limitations, there is a growing body of evidence favoring the use of ALT.…”

Section: Currently Used Approaches Do Not Specifically Target Biofilmmentioning

confidence: 99%

“…In addition, large uncontrolled studies demonstrated high cure rates in patients with uncomplicated LTIVC-related BSI due to coagulase-negative staphylococci (CoNS) (89%) or Gram-negative rods (GNR) (95%) (241,243,244). Thus, the current indication for ALT is uncomplicated LTIVC-related BSI caused by CoNS or GNR (90,194). Aside from commonly used antimicrobials in ALT, ethanol and daptomycin have recently been used for conservative treatment (see the previous section for daptomycin data).…”

Section: Currently Used Approaches Do Not Specifically Target Biofilmmentioning

confidence: 99%

See 3 more Smart Citations

Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics

Lebeaux

Ghigo

Beloin

2014

Microbiol Mol Biol Rev

Self Cite

997

862

View full text Add to dashboard Cite

International audienceSurface-associated microbial communities, called biofilms, are present in all environments. Although biofilms play an important positive role in a variety of ecosystems, they also have many negative effects, including biofilm-related infections in medical settings. The ability of pathogenic biofilms to survive in the presence of high concentrations of antibiotics is called "recalcitrance" and is a characteristic property of the biofilm lifestyle, leading to treatment failure and infection recurrence. This review presents our current understanding of the molecular mechanisms of biofilm recalcitrance toward antibiotics and describes how recent progress has improved our capacity to design original and efficient strategies to prevent or eradicate biofilm-related infections

show abstract

Section: Persisters Play a Central Role In Biofilm Recalcitrance Towamentioning

confidence: 99%

Section: Currently Used Approaches Do Not Specifically Target Biofilmmentioning

confidence: 99%

Section: Currently Used Approaches Do Not Specifically Target Biofilmmentioning

confidence: 99%

Section: Currently Used Approaches Do Not Specifically Target Biofilmmentioning

confidence: 99%

See 2 more Smart Citations

Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics

Lebeaux

Ghigo

Beloin

2014

Microbiol Mol Biol Rev

Self Cite

997

862

View full text Add to dashboard Cite

show abstract

“…The population of people susceptible to this type of infection is growing, mainly as a consequence of an extended life span, increasing numbers of immunocompromised individuals, and use of indwelling medical devices, which can serve as a substrate for biofilm formation (3)(4)(5)(6). Therefore, the occurrence of biofilm-associated infections has expanded over the last several decades, and the extent to which they impact the health of human hosts is enormous (7,8).…”

mentioning

confidence: 99%

Artemisinins, New Miconazole Potentiators Resulting in Increased Activity against Candida albicans Biofilms

Cremer

Lanckacker

Cools

et al. 2015

Antimicrob Agents Chemother

View full text Add to dashboard Cite

cMucosal biofilm-related fungal infections are very common, and the incidence of recurrent oral and vulvovaginal candidiasis is significant. As resistance to azoles (the preferred treatment) is occurring, we aimed at identifying compounds that increase the activity of miconazole against Candida albicans biofilms. We screened 1,600 compounds of a drug-repositioning library in combination with a subinhibitory concentration of miconazole. Synergy between the best identified potentiators and miconazole was characterized by checkerboard analyses and fractional inhibitory concentration indices. Hexachlorophene, pyrvinium pamoate, and artesunate act synergistically with miconazole in affecting C. albicans biofilms. Synergy was most pronounced for artesunate and structural homologues thereof. No synergistic effect could be observed between artesunate and fluconazole, caspofungin, or amphotericin B. Our data reveal enhancement of the antibiofilm activity of miconazole by artesunate, pointing to potential combination therapy consisting of miconazole and artesunate to treat C. albicans biofilm-related infections.

show abstract

Assessment of Novel Long‐Lasting Ceria‐Stabilized Zirconia‐Based Ceramics with Different Surface Topographies as Implant Materials

Altmann

Karygianni

Al‐Ahmad

et al. 2017

Adv Funct Materials

View full text Add to dashboard Cite

The development of long-lasting zirconia-based ceramics for implants, which are not prone to hydrothermal aging, is not satisfactorily solved. Therefore, this study is conceived as an overall evaluation screening of novel ceriastabilized zirconia-alumina-aluminate composite ceramics (ZA 8 Sr 8 -Ce11) with different surface topographies for use in clinical applications. Ceriastabilized zirconia is chosen as the matrix for the composite material, due to its lower susceptibility to aging than yttria-stabilized zirconia (3Y-TZP). This assessment is carried out on three preclinical investigation levels, indicating an overall biocompatibility of ceria-stabilized zirconia-based ceramics, both in vitro and in vivo. Long-term attachment and mineralized extracellular matrix (ECM) deposition of primary osteoblasts are the most distinct on porous ZA 8 Sr 8 -Ce11 p surfaces, while ECM attachment on 3Y-TZP and ZA 8 Sr 8 -Ce11 with compact surface texture is poor. In this regard, the animal study confirms the porous ZA 8 Sr 8 -Ce11 p to be the most favorable material, showing the highest bone-to-implant contact values and implant stability post implantation in comparison with control groups. Moreover, the microbiological evaluation reveals no favoritism of biofilm formation on the porous ZA 8 Sr 8 -Ce11 p when compared to a smooth control surface. Hence, together with the in vitro in vivo assessment analogy, the promising clinical potential of this novel ZA 8 Sr 8 -Ce11 as an implant material is demonstrated.

show abstract

Management of infections related to totally implantable venous-access ports: challenges and perspectives

Cited by 157 publications

References 145 publications

Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics

Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics

Artemisinins, New Miconazole Potentiators Resulting in Increased Activity against Candida albicans Biofilms

Assessment of Novel Long‐Lasting Ceria‐Stabilized Zirconia‐Based Ceramics with Different Surface Topographies as Implant Materials

Contact Info

Product

Resources

About