Assessment of Novel Long‐Lasting Ceria‐Stabilized Zirconia‐Based Ceramics with Different Surface Topographies as Implant Materials

Abstract

The development of long-lasting zirconia-based ceramics for implants, which are not prone to hydrothermal aging, is not satisfactorily solved. Therefore, this study is conceived as an overall evaluation screening of novel ceriastabilized zirconia-alumina-aluminate composite ceramics (ZA 8 Sr 8 -Ce11) with different surface topographies for use in clinical applications. Ceriastabilized zirconia is chosen as the matrix for the composite material, due to its lower susceptibility to aging than yttria-stabilized zirconia (3Y-TZP). This assessment is carried out on three preclinical investigation levels, indicating an overall biocompatibility of ceria-stabilized zirconia-based ceramics, both in vitro and in vivo. Long-term attachment and mineralized extracellular matrix (ECM) deposition of primary osteoblasts are the most distinct on porous ZA 8 Sr 8 -Ce11 p surfaces, while ECM attachment on 3Y-TZP and ZA 8 Sr 8 -Ce11 with compact surface texture is poor. In this regard, the animal study confirms the porous ZA 8 Sr 8 -Ce11 p to be the most favorable material, showing the highest bone-to-implant contact values and implant stability post implantation in comparison with control groups. Moreover, the microbiological evaluation reveals no favoritism of biofilm formation on the porous ZA 8 Sr 8 -Ce11 p when compared to a smooth control surface. Hence, together with the in vitro in vivo assessment analogy, the promising clinical potential of this novel ZA 8 Sr 8 -Ce11 as an implant material is demonstrated.

Controlling osteoblast morphology and proliferation via surface micro-topographies of implant biomaterials

“…Thus, our results demonstrate that both surface parameters S tr and S dr appear to be suitable to predict AO behaviour with respect to morphology and proliferation on implant surfaces in vitro and could be considered as cell instructive surface features during implant processing. The lack of correlation between S a /S q and cell behavioural parameters found in this investigation together with our recently published report, which describes different cell and tissue reactions to implant surfaces with similar roughness values but different surface micro-architecture 6 , thereby add to the body of evidence that a surface specification by S a and/or R a may not allow reliable conclusions on osteoblast behaviour.…”

“…In our previous studies we demonstrated that implant surface topography and chemistry influence bone cell response in vitro and in vivo 6 , 38 , 39 , thereby pointing to cell instructive biomaterial properties, which emerge from implant-inherent features. Based on these findings, we here investigated whether specific topographical and/or chemical surface features of differently modified zirconia-based implant materials can be correlated to alterations in cell morphogenesis and proliferation.…”

“…In this context, various surface modification methods have been developed to roughen the metallic or ceramic implant surfaces. Although the different modification techniques are suitable to create the necessary average surface roughness, they yield different micro- and nanotopographical surface characteristics, which lead to different cellular reactions 6 . Together with the results from clinical studies which report a lack of beneficial effect of implant surface roughness on the long-term preservation of the peri-implant marginal bone level 7 , these findings suggest that other details of the surface structure can be more determining on cell-biomaterial interaction than their roughness degree 8 .…”

<p>The Advances of Ceria Nanoparticles for Biomedical Applications in Orthopaedics</p>

“…ZA 8 Sr 8 -Ce 11 with microporous morphology is one of the best materials for clinical application. 122 The 3D-printed Ce-TZP/Al 2 O 3 showed compression strength similar to that of leather bone, almost 200 MPa. Besides, the viability and differentiation ability of cultured cells are also powerful.…”

Keramikimplantate: Was wissen wir?

“…Im Rahmen eines EU-Projektes wurde eine Dispersionskeramik auf Ce-TZP-Basis untersucht, die mit äquiaxialem Aluminiumoxid und länglichem Strontiumhexaaluminat zwei sekundäre Phasen enthält. So konnten Härte, Biegefestigkeit und Risszähigkeit auf ein ausreichendes Niveau angehoben werden [43,75,76]. Bei einem Cer-Gehalt zwischen 10,5 und 11,5 mol% konnte keine nennenswerte Niedertemperaturumwandlung mehr festgestellt werden.…”