Management of gastrointestinal stromal tumours: a single-centre experience

Abstract

GISTs are rare and surgical resection, increasingly with minimally invasive approaches, is associated with high cure rates, particularly in gastric tumours.

Management and Outcome of Gastrointestinal Stromal Tumors of the Duodenum

“…6,8 These tumors are characterized by expression of a transmembrane receptor tyrosine kinase KIT, a product of the c-kit protooncogene, and identified by expression of CD117 antigen. 1 GISTs can occur anywhere throughout the gastrointestinal tract but are most commonly found in the stomach or small intestine.…”

“…1 GISTs can occur anywhere throughout the gastrointestinal tract but are most commonly found in the stomach or small intestine. 5,6 These tumors may also occur in the peritoneum and extragastrointestinal sites. 9 The small intestine is the second most common site of GISTs, of which approximately 20% are found in the duodenum.…”

“…3,4 The commonest site of origin is the stomach (60-70% of cases), followed by the small intestine (30%) and rarely from the rectum (5%), esophagus, colon, and appendix. 5,6 GISTs may arise in extra intestinal sites in up to 5% of cases. 5,6 Duodenal GISTs comprise a relatively small subset of GISTs with a reported frequency of 6-21% of surgically resected GISTs.…”

“…5,6 GISTs may arise in extra intestinal sites in up to 5% of cases. 5,6 Duodenal GISTs comprise a relatively small subset of GISTs with a reported frequency of 6-21% of surgically resected GISTs. 2,7 The optimal management of GISTs is surgical resection with clear margins.…”

Surgical Therapy for Gastrointestinal Stromal Tumours of the Upper Gastrointestinal Tract

“…We however found a broader age range (21-94 years) to that reported (40-80 years). [9][10][11] Bleeding and anaemia are a common presentation (42%) and the development of symptoms is related to the size of the tumour. Larger tumours may also present with pain and obstruction.…”