Management of Fulminating Ulcerative Colitis in Childhood with Chimeric Anti‐CD25 Antibody

Schwarzer, A.; Ricciardelli, Ida; Kirkham, Sian; Binnie, K; Shah, Neha; Elawad, Mamoun; Hill, S M; Furman, M; Smith, Virpi V.; Sebire, Neil J.; Milla, P J; Londei, Marco; Lindley, Keith

doi:10.1097/01.mpg.0000189347.32796.c5

Cited by 24 publications

(9 citation statements)

References 16 publications

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“…Based on the pancreatic disorders reported in the studies, three subgroup analyses were performed as follows: (1) studies on acute pancreatitis, (2) studies on chronic pancreatitis, and (3) studies related to asymptomatic elevation of pancreatic enzymes. Three articles presented data on pancreatitis without specifying whether it was acute or chronic [ 1 , 21 , 45 ]. No cases of severe disability or mortality due to pancreatitis were reported in the pediatric IBD population.…”

Section: Resultsmentioning

confidence: 99%

Pancreatic Disorders in Children with Inflammatory Bowel Disease

et al. 2021

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Background and Objectives: Inflammatory bowel disease (IBD) is a chronic condition and mainly affects the intestines, however, the involvement of the other organs of the gastrointestinal tract (upper part, pancreas, and liver) have been observed. The coexistence of IBD with pancreatic pathology is rare, however, it has been diagnosed more frequently during recent years in the pediatric population. This article reviews the current literature on the most common pancreatic diseases associated with IBD in the pediatric population and their relationship with IBD activity and treatment. Materials and Methods: We performed a systematic review of data from published studies on pancreatic disorders, also reported as extraintestinal manifestations (EIMs), among children with IBD. We searched PubMed and Web of Science to identify eligible studies published prior to 25 April 2020. Results: Forty-four papers were chosen for analysis after a detailed inspection, which aimed to keep only the research studies (case control studies and cohort studies) or case reports on children and only those which were written in English. The manifestations of IBD-associated pancreatic disorders range from asymptomatic increase in pancreatic enzymes activity to severe disease such as acute pancreatitis. Acute pancreatitis (AP) induced by drugs, mainly thiopurine, seems to be the most- often-reported pancreatic disease associated with IBD in children. AP associated with other than drug etiologies, and chronic pancreatitis (CP), are rarely observed in the course of pediatric IBD. The pancreatic involvement can be strictly related to the activity of IBD and can also precede the diagnosis of IBD in some pediatric patients. The course of AP is mild in most cases and may occasionally lead to the development of CP, mainly in cases with a genetic predisposition. Conclusions: The involvement of the pancreas in the course of IBD may be considered as an EIM or a separate co-morbid disease, but it can also be a side effect of IBD therapy, therefore a differential diagnosis should always be performed. As the number of IBD incidences with concomitant pancreatic diseases is constantly increasing in the pediatric population, it is important to include pancreatic enzymes level measurement in the workup of IBD.

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Section: Resultsmentioning

confidence: 99%

Pancreatic Disorders in Children with Inflammatory Bowel Disease

et al. 2021

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“…Interestingly, patients with pulmonary EIM have been concurrently seen to have other EIMs such as pyoderma gangrenosum and spondylarthropathies [15] . When the use of infliximab for pulmonary EIM was reviewed, only eight cases ( Table 1 ) were discovered [6–11] . Most were case reports or brief case series in patients with Crohn's disease.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, infliximab has also been shown to improve some EIM refractory to conventional immunosuppressive therapy. Only a few cases of IBD associated pulmonary EIM treated with infliximab are found in the literature [6–11] . We present a case of Crohn's disease with pulmonary EIM treated with infliximab and a literature review.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory bowel disease of the lung: The role of infliximab?

Hayek

Pfanner

White

2015

Respiratory Medicine Case Reports

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Pulmonary extra-intestinal manifestations (EIM) of inflammatory bowel disease are well described with a variable incidence. We present a case of Crohn's disease with pulmonary EIM including chronic bronchitis with non-resolving bilateral cavitary pulmonary nodules and mediastinal lymphadenopathy successfully treated with infliximab. Additionally, we present a case summary from a literature review on pulmonary EIM successfully treated with infliximab. Current treatment recommendations include an inhaled and/or systemic corticosteroid regimen which is largely based on case reports and expert opinion. We offer infliximab as an adjunctive therapy or alternative to corticosteroids for treatment of inflammatory bowel disease related pulmonary EIM.

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“…У взрослых показано, что инфликсимаб может быть эффективным для лечения внекишечных проявлений БК [95]. Применение инфликсимаба у детей с внекишечными проявлениями было описано в исследовании серии случаев пациентов с гангренозной пио-дермией, поражением лица и полости рта, эритемой, метастатическим поражением кожи полового члена и кожи мошонки при БК, увеитом, первичным поражением легких, первичным склерозирующим холангитом в сочетании с панкреатитом и остеомиелитом [96][97][98][99][100]. [101], наблюдалось полное заживление слизистой оболочки через 10 недель у 23% из 66 получавших лечение анти-ФНО детей с БК.…”

Section: внекишечные проявления бкunclassified

Draft recommendations of the russian society of pediatric gastroenterology, hepatology and nutrition on diagnosis and treatment of Crohn's disease in children

Корниенко

Хавкин

Федулова

et al. 2019

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The final version of the draft protocol for the diagnosis and treatment of Crohn’s disease in children, developed by experts of the Russian Society of Pediatric Gastroenterology, Hepatology and Nutrition, is presented in the article. This project has been repeatedly discussed by pediatric gastroenterologists - specialists in the study of IBD in children during round tables at the XXV-th and XXVI-th Congres of Pediatric Gastroenterologists of Russia and, after final approval, will be presented in the form of clinical recommendations.

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Management of Fulminating Ulcerative Colitis in Childhood with Chimeric Anti‐CD25 Antibody

Cited by 24 publications

References 16 publications

Pancreatic Disorders in Children with Inflammatory Bowel Disease

Pancreatic Disorders in Children with Inflammatory Bowel Disease

Inflammatory bowel disease of the lung: The role of infliximab?

Draft recommendations of the russian society of pediatric gastroenterology, hepatology and nutrition on diagnosis and treatment of Crohn's disease in children

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