Management of Fibromyalgia Syndrome

Effect of Intravenous Lidocaine on Manifestations of Fibromyalgia

“…Amitriptyline acts by inhibiting the reuptake of serotonin and noradrenaline 12,13 and by blocking sodium channels 14 . The effective analgesic dose ranges from 25 to 75 mg/day 1,10 . In the present study, 25 mg was sufficient to reduce pain intensity and an analgesic effect was observed within 4 weeks as reported in the literature 1 .…”

“…The most frequently indicated and most effective drugs for the treatment of fibromyalgia are antidepressants 1,7–11 . Tricyclic antidepressants seem to be the most effective for the treatment of pain and other manifestations of fibromyalgia such as fatigue, sleep disorders, and mood changes 9,11 .…”

“…The diffuse and complex nature of this condition suggests a central neurophysiological mechanism accompanied by a lower pain threshold. The incidence of fibromyalgia ranges from 85 to 90% among females and its prevalence is higher between 40 and 60 years of age 1 …”

Effect of Intravenous Lidocaine Associated With Amitriptyline on Pain Relief and Plasma Serotonin, Norepinephrine, and Dopamine Concentrations in Fibromyalgia

“…19 As the effective dose of amitriptyline ranges from 25 to 75 mg/d, 14,15 we chose 25 mg. An analgesic effect is usually obtained within 1 week, but may also occur only after 4 to 6 weeks. 15 In our study, significant pain relief was observed in the third week of treatment.…”

“…[11][12][13][14][15] Most of the studies involve tricyclic antidepressants that seem to be the most effective in the treatment of pain and other manifestations of FM such as fatigue, sleep disorders, and mood changes. 11,13 Tricyclic antidepressive agents are effective in about 40% of patients.…”