Effect of Intravenous Lidocaine on Manifestations of Fibromyalgia

Vlainich, Roberto; Issy, Adriana Machado; Gerola, Luís Roberto; Sakata, Rioko Kimiko

doi:10.1111/j.1533-2500.2010.00362.x

Cited by 20 publications

(19 citation statements)

References 19 publications

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“…Similar to previous studies, there was a higher percentage of women participating in this study. The age of the patients was similar to the values previously reported in the literature, with a higher prevalence of individuals aged between 40 and 60 years …”

Section: Discussionsupporting

confidence: 89%

“…Nevertheless, there is controversy in conditions without nerve damage. Previously our group studied intravenous lidocaine for fibromyalgia patients, evaluating the symptoms and serotonin, norepinephrine and dopamine concentrations . Regarding the use of systemic lidocaine in fibromyalgia, there are no well‐controlled studies assessing cytokines, which motivated the elaboration of this study.…”

Section: Introductionmentioning

confidence: 99%

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Effect of intravenous lidocaine combined with amitriptyline on pain intensity, clinical manifestations and the concentrations ofIL‐1,IL‐6 andIL‐8 in patients with fibromyalgia: A randomized double‐blind study

et al. 2016

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Effect of intravenous lidocaine combined with amitriptyline on pain intensity, clinical manifestations and the concentrations ofIL‐1,IL‐6 andIL‐8 in patients with fibromyalgia: A randomized double‐blind study

et al. 2016

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“…Three studies met inclusion criteria and found that infusions of 240 mg of IV lidocaine once a week for 4 weeks, in patients with FM all taking amitriptyline, did not provide superior efficacy for pain relief compared to patients receiving placebo infusions 128–130 .…”

Section: Findings From Studies Grouped By Chronic Pain Syndromementioning

confidence: 99%

Alternatives to Opioids in the Pharmacologic Management of Chronic Pain Syndromes: A Narrative Review of Randomized, Controlled, and Blinded Clinical Trials

Nicol

Hurley

Benzon

2017

Anesthesia &Amp; Analgesia

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Chronic pain exerts a tremendous burden on individuals and societies. If one views chronic pain as a single disease entity, then it is the most common and costly medical condition. At present, medical professionals who treat patients in chronic pain are recommended to provide comprehensive and multidisciplinary treatments, which may include pharmacotherapy. Many providers employ non-opioid medications to treat chronic pain, however, for some patients, opioid analgesics are the exclusive treatment of chronic pain. However, there is currently an epidemic of opioid use in the United States, and recent guidelines from the Centers for Disease Control (CDC) have recommended that the use of opioids for non-malignant chronic pain be used only in certain circumstances. The goal of this review was to report the current body of evidence-based medicine gained from prospective, randomized-controlled, blinded studies on the use of non-opioid analgesics for the most common non-cancer chronic pain conditions. A total of 9566 studies were obtained during literature searches and 271 of these met inclusion for this review. Overall, while many non-opioid analgesics have been found to be effective in reducing pain for many chronic pain conditions, it is evident that the number of high-quality studies is lacking and the effect sizes noted in many studies is not considered to be clinically significant despite statistical significance. More research is needed to determine effective and mechanisms-based treatments for the chronic pain syndromes discussed in this review. Utilization of rigorous and homogeneous research methodology would likely allow for better consistency and reproducibility, which is of utmost importance in guiding evidence-based care.

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“…100 However, a recent study of 68 FM patients with MPS and 56 FM patients with regional joint pain showed that peripheral TrP injections and hydroelectrophoresis ameliorated FM pain and increased pain thresholds at sites distant from the therapeutic interventions, thus providing further evidence that painful peripheral stimuli contribute to the perpetuation of central augmentation. 100 However, a recent study of 68 FM patients with MPS and 56 FM patients with regional joint pain showed that peripheral TrP injections and hydroelectrophoresis ameliorated FM pain and increased pain thresholds at sites distant from the therapeutic interventions, thus providing further evidence that painful peripheral stimuli contribute to the perpetuation of central augmentation.…”

Section: Local Anestheticsmentioning

confidence: 99%

Chronic Widespread Pain

Adams¹,

Clauw²

2014

Practical Management of Pain

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Effect of Intravenous Lidocaine on Manifestations of Fibromyalgia

Abstract: The addition of 240 mg intravenous lidocaine (once a week) to 25 mg amitriptyline for 4 weeks did not modify pain intensity or manifestations in patients with fibromyalgia compared with amitriptyline alone.

Cited by 20 publications

References 19 publications

Effect of intravenous lidocaine combined with amitriptyline on pain intensity, clinical manifestations and the concentrations ofIL‐1,IL‐6 andIL‐8 in patients with fibromyalgia: A randomized double‐blind study

Effect of intravenous lidocaine combined with amitriptyline on pain intensity, clinical manifestations and the concentrations ofIL‐1,IL‐6 andIL‐8 in patients with fibromyalgia: A randomized double‐blind study

Alternatives to Opioids in the Pharmacologic Management of Chronic Pain Syndromes: A Narrative Review of Randomized, Controlled, and Blinded Clinical Trials

Chronic Widespread Pain

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