Management of extramedullary plasmacytoma: Role of radiotherapy and prognostic factor analysis in 55 patients

Wen, Ge; Wang, Weihu; Zhang, Yujing; Niu, Shaoqing; Li, Qiwen; Li, Yexiong

doi:10.21147/j.issn.1000-9604.2017.05.08

Cited by 22 publications

(37 citation statements)

References 32 publications

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“…All these prognostic factors were absent in our patient pointing toward an adverse outcome. 3 Our patient was diagnosed as primary EMP because the diagnosis of plasmacytoma was made before the diagnosis of MM. To date, there are more than 63 cases in the English literature of EMP with pancreatic involvement.…”

Section: Discussionmentioning

confidence: 96%

“…After 2 months, the patient saw her family physician and complained of decrease appetite, worsening periumbilical discomfort and a pulsatile mass in her abdomen. She was found to be anemic with hemoglobin of 9.5 g/dL, hematocrit of 29.4%, and platelet of 123 000/mm 3 . Electrolyte profile showed borderline hypokalemia (potassium levels of 3.3 mg/ dL and normal calcium levels (9.5 mg/dL).…”

Section: Case Summarymentioning

confidence: 99%

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Pancreatic Extramedullary Plasmacytoma Presenting as a Pancreatic Mass

Surapaneni

Jain

et al. 2018

Clin Med Insights Gastroenterol

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Extramedullary plasmacytomas (EMP) are a subcategory of plasma cell neoplasm that involves organs outside the bone marrow. Involvement of the pancreas is relatively rare, reported in only 2.3% of autopsies. Radiologic findings in plasmacytoma are nonspecific, but endoscopic ultrasound fine-needle aspiration is a fast and reliable technique to acquire a histologic sample for initial diagnosis. Recently, the use of fluorine-18 fluorodeoxyglucose PET/CT has been recommended in patients with active multiple myeloma and solitary plasmacytoma. We present an interesting case of primary EMP in the pancreatic body encasing the portal vein as well as the celiac artery, which was detected before the patient was diagnosed of multiple myeloma.

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Section: Discussionmentioning

confidence: 96%

Section: Case Summarymentioning

confidence: 99%

Pancreatic Extramedullary Plasmacytoma Presenting as a Pancreatic Mass

Surapaneni

Jain

et al. 2018

Clin Med Insights Gastroenterol

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“…70.3 % (p=0.027) for patients with EMP of the head and neck region receiving radiation or surgery respectively. 2 …”

Section: Discussionmentioning

confidence: 99%

Surgery Results in Low Relapse and Progression Rates in Extramedullary Plasmacytoma of the Head and Neck: A Case Cohort and Review of the Literature

et al. 2020

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Extramedullary plasmacytoma of the head and neck is a rare indolent neoplasm. Radiotherapy is often the preferred treatment option with excellent local control and survival. The risk of local recurrence or transformation to multiple myeloma is 10- 30%. In our case-cohort, thorough, sensitive initial evaluation for disseminated clonal disease and the incorporation of surgery led to excellent results with no recurrences or systemic progression.

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“…The five-year survival rate of EMP ranges from 30% to 82% and 10-year rate ranges from 50% to 90% (1). Patients with head and neck EMP, age <50 years, and tumor size of <4 cm without monoclonal protein (M-protein, M-spike) in serum protein electrophoresis (SPEP) have better outcomes (13).…”

Section: Discussionmentioning

confidence: 99%

Extramedullary Plasmacytoma of the Maxillary Sinus with Intra-Orbital Extension: A Case Report of a Rare Condition

Taheri

Shamsaei

Sharouny

2019

Rep Radiother Oncol

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Introduction: The most common site for extramedullary plasmacytomas (EMP) is the upper respiratory tract, including the oropharyngeal and nasal cavities, paranasal sinuses, and larynx. The EMPs of the head and neck area are uncommon malignancies comprising only 3% to 4% of all the plasmacytomas. Case Presentation: We presented a 78-year-old man with right facial swelling, right exophthalmos, diplopia, and decrease in visual acuity of the right eye for three weeks. A right nasal mass was identified on nasal endoscopic examination. Computed tomography scan of the paranasal sinuses revealed a mass in the right maxillary and ethmoid sinuses with orbital extension. Histopathologic examination showed plasmacytoma of paranasal sinuses. Patient received 56 Gy in 28 fractions of radiotherapy. He was well in the follow-up visits during the next one year. Conclusions: Although sinonasal EMP is rare, it is worth being considered in the differential diagnoses of paranasal malignancies. Radiotherapy is the treatment of choice for solitary EMPs of paranasal sinuses. Long-term follow-up is essential in EMPs.

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Management of extramedullary plasmacytoma: Role of radiotherapy and prognostic factor analysis in 55 patients

Abstract: Involved-site RT of at least 45 Gy should be considered for EMP. Furthermore, patients with head and neck EMP, tumor size <4 cm, age <50 years and serum M protein negativity had better outcomes.

Cited by 22 publications

References 32 publications

Pancreatic Extramedullary Plasmacytoma Presenting as a Pancreatic Mass

Pancreatic Extramedullary Plasmacytoma Presenting as a Pancreatic Mass

Surgery Results in Low Relapse and Progression Rates in Extramedullary Plasmacytoma of the Head and Neck: A Case Cohort and Review of the Literature

Extramedullary Plasmacytoma of the Maxillary Sinus with Intra-Orbital Extension: A Case Report of a Rare Condition

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