Surgery Results in Low Relapse and Progression Rates in Extramedullary Plasmacytoma of the Head and Neck: A Case Cohort and Review of the Literature

Škerget, Matevž; Dovšak, Tadej; Kos, Gregor; Zver, Samo

doi:10.4081/hr.2020.8396

Cited by 2 publications

(3 citation statements)

References 24 publications

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“…Treatment is often guided by a limited number of retrospective studies involving small samples (Table 1). A recent comprehensive population-based analysis found that most SPs are highly radiosensitive and radiation dose >40 Gy is associated with improved survival and decreased recurrence [16]. There are contradictory reports of the benefits of surgery combined with adjuvant radiotherapy [9,[16][17][18].…”

Section: Case Bmentioning

confidence: 99%

“…A recent comprehensive population-based analysis found that most SPs are highly radiosensitive and radiation dose >40 Gy is associated with improved survival and decreased recurrence [16]. There are contradictory reports of the benefits of surgery combined with adjuvant radiotherapy [9,[16][17][18]. Interestingly, the prognosis of SPs is different among SMPs and SBPs due to the increased likelihood of SBP progressing to MM [19].…”

Section: Case Bmentioning

confidence: 99%

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Plasmacytoma of the Head and Neck: Case Series and Review of the Literature

Lamb,

Zeatoun,

Stack

et al. 2023

ORL

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Solitary plasmacytoma is a rare neoplasm characterized by localized proliferation of monoclonal plasma cells and is classified as solitary bone or solitary extramedullary plasmacytoma. Here, we present two rare cases of plasmacytoma of the head and neck. The first is a 78-year-old male who presented with a 3-month history of epistaxis and progressive obstruction of the right nasal passage. Computerized tomography (CT) imaging revealed a mass in the right nasal cavity with destruction to the maxillary sinus. An excisional biopsy was performed revealing anaplastic plasmacytoma. The second is a 64-year-old male with a past medical history significant for prostate cancer who presented with a 2-month history of left ear pain and progressive non-tender temporal swelling. A PET/CT revealed a highly avid, destructive, and lytic left temporal mass with no other evidence of distant disease. A left temporal craniectomy and infratemporal fossa dissection revealed plasma cell dyscrasia with monoclonal lambda in situ hybridization. Although plasmacytomas are uncommon tumors of the head and neck, they may mimic other entities that require different treatment. Prompt and accurate diagnosis is critical for appropriate therapeutic decisions and prognosis.

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Section: Case Bmentioning

confidence: 99%

Section: Case Bmentioning

confidence: 99%

Plasmacytoma of the Head and Neck: Case Series and Review of the Literature

Lamb,

Zeatoun,

Stack

et al. 2023

ORL

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“…These tests help determine the long-term prognosis of solitary plasmacytoma and the risk of progression to multiple myeloma. Surgical treatment has shown positive outcomes in long-term prognosis, while irradiation and systemic therapy may not be recommended as standard treatment protocols [ 7 ]. Here, we present a rare case of the presence of a plasmacytoma in the upper jaw.…”

Section: Introductionmentioning

confidence: 99%

Plasmacytoma in the Maxillary Jaw: A Diagnostic and Therapeutic Challenge

Bernardi,

Bianchi,

Lupi

et al. 2024

Hematology Reports

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Plasmacytoma is a neoplastic disorder originating from plasma cells, with bone and soft tissue being common sites of manifestation. This report presents the clinical and radiological findings of a 65-year-old female patient who presented with an exophytic lesion in the upper right lateral incisor region. The lesion appeared as a unilocular radiotransparent area in imaging tests. Following an excisional biopsy, histological and immunohistochemical evaluations confirmed the presence of mature plasmacellular elements and small infiltrates of B and T lymphocytes. The patient did not exhibit systemic manifestations of multiple myeloma. Surgical intervention, in the form of enucleation of the lesion combined with root canal treatment and apicoectomy, was performed. This case underscores the rare occurrence of plasmacytoma in the jaw region and highlights the importance of surgical management in cases where structural damage or functional impairment is present. Further research on novel treatment approaches is also mentioned, including targeted therapies, immunomodulatory agents, and monoclonal antibodies. The patient is currently under the care of a hematologist for further investigation and the choice of the most appropriate therapy.

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Surgery Results in Low Relapse and Progression Rates in Extramedullary Plasmacytoma of the Head and Neck: A Case Cohort and Review of the Literature

Cited by 2 publications

References 24 publications

Plasmacytoma of the Head and Neck: Case Series and Review of the Literature

Plasmacytoma of the Head and Neck: Case Series and Review of the Literature

Plasmacytoma in the Maxillary Jaw: A Diagnostic and Therapeutic Challenge

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