Management of endometrial modifications in perimenopausal women

Nicula, Renata; Costin, Nicolae

doi:10.15386/cjmed-421

Cited by 14 publications

(21 citation statements)

References 113 publications

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“…The period between the ages of 40 and 55 years corresponds to the perimenopause and is associated with the risk of iron deficiency anemia . This is associated with variations in hormonal levels and also menstrual disturbances with an increased risk of heavy bleeding . Moreover, an unhealthy lifestyle, often with restrictive dieting and a lack of exercise, was reported .…”

Section: Discussionmentioning

confidence: 99%

“…20 This is associated with variations in hormonal levels and also menstrual disturbances with an increased risk of heavy bleeding. 21 Moreover, an unhealthy lifestyle, often with restrictive dieting and a lack of exercise, was reported. 22 Although females of childbearing age are especially at risk F I G U R E 2 Prevalence of anemia according to age groups in both sexes of iron deficiency anemia due to menstrual iron loss, 23 females aged 40-49 years were found to be at a higher risk of anemia than females of childbearing age in our study.…”

Section: Discussionmentioning

confidence: 99%

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Distribution of hemoglobin levels and prevalence of anemia according to sex, age group, and region in 13 Korean cities

Nah

Cho

Kim

et al. 2020

Int J Lab Hematology

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Introduction The distribution of hemoglobin (Hb) levels and the prevalence of anemia are significant public health indicators. The aims of this study were to determine the distribution of Hb levels and the prevalence of anemia according to sex, age group, and region throughout Korea. Methods The study analyzed data on 1 159 298 subjects who received health checkups at 16 health‐promotion centers in 13 Korean cities during 2018. Anemia and its severity were defined according to the World Health Organization classification for Hb levels as follows: mild anemia (11‐12.9 g/dL in males and 11‐11.9 g/dL in females), moderate anemia (10‐10.9 g/dL in both sexes), and severe anemia (<10.0 g/dL in both sexes). Results The Hb level in the general sample was lower in females (13.25 ± 1.13 g/dL, mean ± SD) than in males (15.29 ± 1.22 g/dL). The overall prevalence of anemia was 6.0% (2.98% in males and 8.56% in females), and the prevalence of severe anemia was 0.92% (0.23% in males and 1.51% in females). While the prevalence of anemia increased monotonically with age in males, it was bimodal in females with two peaks at 40‐49 years and ≥80 years. The highest prevalence of anemia in females aged 40‐49 years was attributed to microcytic anemia, while increases in anemia prevalence in males aged ≥50 years and females aged ≥70 years were attributed to macrocytic anemia. Conclusion The distribution of Hb levels and the prevalence of anemia overall and by severity differ according to sex, age group, and region throughout Korea.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Distribution of hemoglobin levels and prevalence of anemia according to sex, age group, and region in 13 Korean cities

Nah

Cho

Kim

et al. 2020

Int J Lab Hematology

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“…The mortality rate of ovarian cancer ranks first in gynecological tumors. Therefore, it is of great significance to improve the diagnosis and treatment of ovarian malignant tumors (10). There is no obvious symptom in the early stage of ovarian cancer.…”

Section: Introductionmentioning

confidence: 99%

Effect of dexmedetomidine anesthesia on perioperative levels of TNF-α and IL-6 in patients with ovarian cancer

Liu

Zhao

2019

Oncol Lett

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Effect of continuous use of dexmedetomidine during general anesthesia on perioperative levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in patients undergoing radical resection of ovarian cancer was investigated. The initial treatment of ovarian cancer is mainly radical surgery. Most patients with ovarian cancer radical surgery can achieve good results, but the use of improper anesthetic drugs in radical surgery can easily lead to unstable patient vital signs. Therefore, the selection of appropriate anesthetic drugs has become the key to radical ovarian cancer surgery. There are few reports on the use of dexmedetomidine in anesthesia for ovarian cancer radical surgery. This study was performed to retrospectively analyze the case data of patients undergoing laparoscopic ovarian cancer radical surgery, and to compare the hemodynamics of dexmedetomidine anesthesia with midazolam anesthesia and the concentrations of TNF-α and IL-6, to provide reference for clinical implementation of ovarian cancer radical surgery. The hemodynamics of patients in the dexmedetomidine group were stable compared with the midazolam group. Serum TNF-α and IL-6 levels were significantly lower in the dexmedetomidine group than that in the midazolam group. If dexmedetomidine were continuously used during general anesthesia, the perioperative serum levels of TNF-α and IL-6 could be effectively reduced in patients undergoing radical resection of ovarian cancer, and the perioperative stress response was suppressed.

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“…Prior studies have indicated that perimenopausal women with a diminished supply of FSH-responsive follicles experience intermittent ovulation or even chronic anovulation during this transition due to hormonal imbalance and menstrual irregularity (Nicula and Costin, 2015). Given our findings from mice that VCD (within a given concentration range) can function to promote oocyte maturation and to promote ovulation independent of FSH, it is of biological and clinical relevance to further examine whether VCD per se may be able to improve ovulatory responses and fertility in perimenopausal women.…”

Section: Discussionmentioning

confidence: 99%

Hormone-Like Effects of 4-Vinylcyclohexene Diepoxide on Follicular Development

Cao

Liu

Lü

et al. 2020

Front. Cell Dev. Biol.

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Background: 4-vinylcyclohexene diepoxide (VCD) has long been considered a hazardous occupational chemical that promotes ovarian failure. However, VCD is also used as a research compound to chemically induce animal models of premature ovarian insufficiency (POI), and in related work we unexpectedly found that VCD apparently exhibits both dose-and duration-dependent opposing, hormone-like effects on the maintenance of the primordial follicle pool, follicle development, and ovulation induction. Results: We conducted experiments with cultured murine ovaries and performed transplantation experiments using postnatal day (PD) 2 and PD12 mice and found that low-dose, short-term exposure to VCD (VCD low) actually protects the primordial/primary follicle pool and improves the functional ovarian reserve (FOR) by disrupting follicular atresia. VCD low inhibits follicular apoptosis and regulates the Pten-PI3K-Foxo3a pathway. Short-term VCD exposure in vivo (80 mg/kg, 5 days) significantly increases the number of superovulated metaphase II oocytes, preovulatory follicles, and corpus luteum in middle-aged mice with diminished ovarian reserve (DOR). We demonstrate that low-dose but not high-dose VCD promotes aromatase levels in granulosa cells (GCs), thereby enhancing the levels of estradiol secretion. Conclusion: Our study illustrates a previously unappreciated, hormone-like action for the occupational "ovotoxin" molecule VCD and strongly suggests that VCD low should be explored for its potential utility for treating human ovarian follicular development disorders, including subfertility in perimenopausal women.

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Management of endometrial modifications in perimenopausal women

Cited by 14 publications

References 113 publications

Distribution of hemoglobin levels and prevalence of anemia according to sex, age group, and region in 13 Korean cities

Distribution of hemoglobin levels and prevalence of anemia according to sex, age group, and region in 13 Korean cities

Effect of dexmedetomidine anesthesia on perioperative levels of TNF-α and IL-6 in patients with ovarian cancer

Hormone-Like Effects of 4-Vinylcyclohexene Diepoxide on Follicular Development

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