Management of endemic outbreaks of scabies with allethrin, permethrin, and ivermectin

Paasch, Uwe; Haustein, U.‐F.

doi:10.1046/j.1365-4362.2000.00990.x

Cited by 52 publications

(42 citation statements)

References 31 publications

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“…Several clinical studies have shown that permethin achieves higher clearance rates than lindane and crotomiton. 28 Mass treatment with permethrin has also been effective in controlling scabies in communities in which it is endemic.…”

Section: Permethrinmentioning

confidence: 99%

Scabies in children

Karthikeyan

2007

Archives of Disease in Childhood - Education and Practice

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Scabies is a common dermatological problem managed by both paediatricians and dermatologists. It manifests itself in various forms in children and differs from that in adults in many ways. The treatment of scabies has developed with the evolution of new strategies and anti-ectoparasitic drugs. Drugs such as permethrin and ivermectin have revolutionised its treatment. The management of scabies not only includes prescribing the correct drugs but also educating patients about their application. Treatment failure can result from a variety of causes and must be managed appropriately.

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Section: Permethrinmentioning

confidence: 99%

Scabies in children

Karthikeyan

2007

Archives of Disease in Childhood - Education and Practice

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“…Although large studies showed that permethrin had low toxicity in mammals, active permethrin could not be detected in blood and urine in some studies conducted on volunteers. This drug was reported to be used also in rosacea depending on the results of the studies on facial demodicidosis and diseases associated with other mites [9, 10, 11]. …”

Section: Introductionmentioning

confidence: 99%

Permethrin 5% Cream versus Metronidazole 0.75% Gel for the Treatment of Papulopustular Rosacea

et al. 2002

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Background: Permethrin 5% cream used against human ectoparasites suggests that it may be effective in papulopustular rosacea. Methods: This study included 63 patients diagnosed as having papulopustular rosacea based on the clinical and histological findings. Patients were randomly assigned into permethrin (n = 23), metronidazole (n = 20) and placebo (n = 20) groups. Scores of erythema, telangiectasia, edema and rhinophyma and the numbers of papules, pustules, inflammatory nodules and Demodex folliculorum were determined. Twenty-three patients were given permethrin 5% cream (Zalvor 5% skin cream^®), 20 patients metronidazole 0.75% gel (Roza gel^®) and 20 patients placebo cream (Basis cream^®), in packages looking identical to those of metronidazole and permethrin creams, and were recommended to apply them to their faces twice a day. All patients were also given SPF 20 cream for protection against sunlight. Two months of treatment were planned, and the patients were invited to the clinic for fortnightly controls. Scores of erythema, telangiectasia, edema and rhinophyma and the numbers of papules, pustules, inflammatory nodules and D. folliculorum were recorded at each visit. The mean scores of erythema and the mean numbers of papules, pustules and D. folliculorum were determined at baseline and on days 15, 30, 45 and 60. Side effects were also detected. Results: The effect of permethrin 5% cream on D. folliculorum was superior to that of metronidazole 0.75% gel. The effect of permethrin 5% cream on erythema and papules was found to be more effective than placebo and as effective as metronidazole 0.75% gel. However, it had no effect on telangiectasia, rhinophyma and pustules. Conclusion: It can be concluded that the application of permethrin 5% cream twice daily for 2 months can be as effective and reliable as metronidazole in the treatment of rosacea and a greater benefit can be gained when it is combined with other systemic and/or topical treatments.

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“…Several studies have shown that permethrin has a higher clearance rate than lindane and crotamiton. 28 The limiting factor in the use of permethrin is its cost as it is the most expensive of all the topical scabicides. 4 The various topical antiscabietic agents and their side effects are summarised in table 2.…”

Section: Malathionmentioning

confidence: 99%

Treatment of scabies: newer perspectives

Karthikeyan¹

2005

Postgraduate Medical Journal

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Scabies is a common dermatological problem managed by general physicians, family physicians, and dermatologists. Scabies manifests itself in various forms in different individuals. The treatment of scabies has undergone developments with the evolution of new treatment strategies and antiectoparasitic drugs. The advent of drugs such as permethrin and ivermectin has revolutionised treatment. Management of scabies not only includes prescribing the drugs but also educating patients properly about the method of application of the drug. Treatment failures may result for various reasons and must be managed appropriately.

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Management of endemic outbreaks of scabies with allethrin, permethrin, and ivermectin

Cited by 52 publications

References 31 publications

Scabies in children

Scabies in children

Permethrin 5% Cream versus Metronidazole 0.75% Gel for the Treatment of Papulopustular Rosacea

Treatment of scabies: newer perspectives

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