Management of early pregnancy failure

Gariepy, Aileen M.; Chen, Beatrice A.

doi:10.3109/9781841848259.029

Cited by 4 publications

(4 citation statements)

References 25 publications

(32 reference statements)

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“…Surgical evacuation has been the standard treatment for years. However, considering the long-term sequelae of surgical management in subsequent pregnancies, the role of medical management becomes utmost important [2].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Mifepristone Followed by Misoprostol with Misoprostol Alone for Treatment of Early Pregnancy Failure: A Randomized Double-Blind Placebo-Controlled Trial

Sinha

Suneja

Guleria

et al. 2017

J Obstet Gynecol India

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Section: Introductionmentioning

confidence: 99%

Comparison of Mifepristone Followed by Misoprostol with Misoprostol Alone for Treatment of Early Pregnancy Failure: A Randomized Double-Blind Placebo-Controlled Trial

Sinha

Suneja

Guleria

et al. 2017

J Obstet Gynecol India

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“…Misoprostol is an effective agent commonly used in the treatment of miscarriages but in spite of the studies that have been conducted the optimal dose and route of administration of misoprostol have not been determined yet [5]. Studies showed that the degree of absorption of misoprostol and its effect on uterine contractility after vaginal misoprostol was more long-lasting and more continuously increasing uterine contractility comparing to the time when oral misoprostol was administered After vaginal administration [3].…”

Section: Discussionmentioning

confidence: 99%

“…More than one regimen may be effective at a particular stage of pregnancy [4]. Misoprostol is an effective agent commonly used in the treatment of miscarriages especially missed miscarriage, but optimal dose and route of administration of misoprostol have not been determined by randomised trials [5]. Even the World Health Organization has not recommended a standard regimen for administration of misoprostol in the treatment of missed miscarriage [6].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Effectiveness and Patient Satisfaction of Vaginal Versus Oral Misoprostol in Treatment of Missed Miscarriage

Mohammadi¹,

Jayaprakash²,

Shiva³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: In recent years’ medical management with misoprostol is an effective alternative to surgical evacuation. But there is a dearth of evidence to reveal the effectiveness of the different routes of misoprostol and satisfaction rate among the patients treated with these routes. AIM: This study was conducted to compare the effectiveness and patient’s satisfaction rate of vaginal versus oral misoprostol. METHODS: It was a prospective non-interventional study. One hundred women of having missed abortion confirmed by ultrasonography examination were enrolled in the trial. Fifty-eight subjects were administered 200 mcg of oral and 42 subjects received 200 mcg of vaginal misoprostol every four hours up to four doses. If complete expulsion did not occur 12 hours after the last dose, the surgical evacuation was done. RESULTS: There was no significant statistical difference between the effectiveness of treatment with vaginal (78.57%) and oral misoprostol (79.31%) (p = 0.928). The difference between Patients’ satisfaction at the time of discharge for the vaginal group (64.29%) and oral group (65.52%) was not statistically significant (P = 0.991). There was an increase in patients’ satisfaction for both groups at the follow-up session, but still, the difference was not significant (P = 0.897). CONCLUSION: This study confirms that there is no statistical difference between the effectiveness and patient satisfaction of oral and vaginal misoprostol in the treatment of missed abortion.

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“…Surgical management is defined by mechanical removal of tissue from the uterus, Successful management entails complete evacuation of the uterus. The success of each of these approaches depends on several factors including the type of loss (eg, with or without symptoms such as bleeding and cramping [2].…”

Section: Introductionmentioning

confidence: 99%

Misoprostol plus Isosorbide Mononitrate versus Misoprostol for Termination of Anembryonic Pregnancy

2021

AHS

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Objective: Is to to assess the efficacy and safety of vaginal misoprostol plus isosorbide mononitrate versus misoprostol in termination of anembryonic pregnancy. Setting: Department of Obstetrics and Gynecology, Woman’s Health Hospital, Assiut University. Methods: 108 women scheduled for termination of anembryonic pregnancy were recruited were assigned randomly to vaginal misoprostol 800 g plus isosorbide mononitrate 40 mg or vaginal misoprostol 800 g plus placebo .The efficacy of the medication was evaluated by predetermined outcome variables for Successful expulsion of gestational sac in both groups and need for surgical interference.

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Management of early pregnancy failure

Cited by 4 publications

References 25 publications

Comparison of Mifepristone Followed by Misoprostol with Misoprostol Alone for Treatment of Early Pregnancy Failure: A Randomized Double-Blind Placebo-Controlled Trial

Comparison of Mifepristone Followed by Misoprostol with Misoprostol Alone for Treatment of Early Pregnancy Failure: A Randomized Double-Blind Placebo-Controlled Trial

Comparison of Effectiveness and Patient Satisfaction of Vaginal Versus Oral Misoprostol in Treatment of Missed Miscarriage

Misoprostol plus Isosorbide Mononitrate versus Misoprostol for Termination of Anembryonic Pregnancy

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