Comparison of Effectiveness and Patient Satisfaction of Vaginal Versus Oral Misoprostol in Treatment of Missed Miscarriage

Mohammadi, Elham; Jayaprakash, Geetha; Shiva, Atena; Motallebzadeh, Nader

doi:10.3889/oamjms.2019.192

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…However, several risks, such as postoperative infection, accompany surgical procedures. However, effective, safe, and socially acceptable medical care has emerged in recent years (4) .…”

Section: Introductionmentioning

confidence: 99%

Study of Oral Versus Vaginal Misoprostol in the Management of Early Pregnancy Loss

Abdou,

Ahmed,

Abd elhafez

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Research conducted by specialists does not show that oral misoprostol is more successful than vaginal misoprostol to manage early pregnancy loss, and vice versa. Objective: To compare oral versus vaginal misoprostol for managing early pregnancy loss. Subjects and Methods: A prospective randomized controlled trial that was performed on 102 women attending to Obstetrics and Gynecology Department and diagnosed with missed abortion on ultrasound. They were divided into 2 groups. (Group A: Vaginal Misoprostol): Intravaginally into the posterior fornix, 51 patients were administered 600 μg of misoprostol soaked in normal saline solution, which was repeated three-hourly up to a maximum of two doses. Group B (Oral Misoprostol): Misoprostol 600 g was orally administered to 51 patients with a maximum of two doses, each separated by three hours. Results: All of incidence of hypotension, mean of satisfaction, and mean of successful rate were statistically significantly higher as compared with the cases in group B. incidence of side effects was statistically significantly higher in the cases of group B as compared with the cases in group A. Mean induction-expulsion interval in the cases of group A (9.5±3.3) was shorter as compared with the cases in group B (10.8±2.2) with non-statistically significant difference (p=0.078). conclusion: Misoprostol use by the vaginal route is more efficacious than oral route. Vaginal route was found to have cervical ripening effect and did not need much monitoring to become the first choice even over surgical for induction of labor.

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“…However, several risks, such as postoperative infection, accompany surgical procedures. However, effective, safe, and socially acceptable medical care has emerged in recent years (4) .…”

Section: Introductionmentioning

confidence: 99%

Study of Oral Versus Vaginal Misoprostol in the Management of Early Pregnancy Loss

Abdou,

Ahmed,

Abd elhafez

et al. 2023

The Egyptian Journal of Hospital Medicine

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“…[ 6 7 ] Some studies have reported higher effectiveness of vaginal administration over the oral route,[ 8 ] while a study by Mohammadi et al has stated that there is no significant difference between the success rate of the vaginal and oral route. [ 9 ] A study by Singh et al [ 10 ] showed that the success rate of treatment in both vaginal and sublingual routes is not significantly different, but the side effects of the drug such as diarrhea and fatigue are reported higher in sublingual administration.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the efficacy of sublingual, oral, and vaginal administration of misoprostol in the medical treatment of missed abortion during first trimester of pregnancy: A randomized clinical trial study

et al. 2020

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Background: This study was aimed at comparing the efficacy of different routes of misoprostol administration, including sublingual, oral, and vaginal, on the induction of medical abortion in the first trimester of pregnancy. Materials and Methods: This open-label, randomized clinical trial study was performed on 172 individuals in three parallel groups of vaginal, sublingual, and oral administration of misoprostol. The participants were randomized using permuted blocks of six. A dose of 600 μg of misoprostol every 6 h (maximum of 4 doses) was administrated to each group. Higham chart and demographic questionnaires were completed by the investigator. Data were analyzed using Stata software version 12. Results: The mean age of the participants was 29.81 ± 6.7 years, and the mean gestational age was 8.45 ± 2.32 weeks. We found a significant difference regarding the abortion success rate and the time interval between the administration of the drug among three groups ( P = 0.036 and < 0.001 in turn). There was no statistically significant difference between the three groups in terms of severity and duration of vaginal bleeding until day 7 after induction ( P = 0.091 and 0.143, respectively). Furthermore, we found statistically significant differences in some drugs, which induced side effects namely vomiting and headache, between the three groups ( P = 0.032 and 0.028 in turn). Conclusion: The findings suggest that vaginal administration of misoprostol is more successful than the sublingual and oral route for complete abortion; vaginal administration of misoprostol is an appropriate alternative to curettage.

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Evaluation of the Effectiveness of Intravaginal Misoprostol in Termination of Pregnancy

Yener¹,

Ateş²,

Sayın³

et al. 2020

Mustafa Kemal Üniversitesi Tıp Dergisi

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tarihleri arasındaki 2,5 yıllık zaman aralığında terminasyon yapılan gebeliklerin endikasyonlarının dağılımını değerlendirmek ve 10 (on) hafta üzeri gebelik sonlandırmasında dört saatte bir intravajinal ve yirmi dört saatte bir vajinal yolla uygulanan sırasıyla 400 μg ve 600 μg mizoprostolün etkinliğini karşılaştırmak. Gereç ve Yöntem: Retrospektif dosya incelemesi şeklinde planlanan çalışmamızda kliniğimizde terminasyon kararı verilen 10 (on) hafta üzeri gebeliklerin sonlandırılma endikasyonları ve uygulanmakta olan mizoprostol tedavi protokollerinin etkinliği incelendi. 18-45 yaş arası, 10 (on) hafta ve üzeri olan gebeliklerin sonlandırıldığı toplam 128 kadının dosyası değerlendirildi. 4 saat ara ile vajinal yolla 400 μg mizoprostol uygulanan 63 hasta Grup 1 olarak alındı. 24 saat ara ile 600 μg vajinal yolla mizoprostol uygulanan 65 hasta Grup 2 olarak alındı. Her iki grupta yeterli uterin kontraksiyon elde edilene kadar doz tekrarlanıp 48 saat sonrasında abortus/doğum gerçekleşmeyen hastalarda yöntem başarısız olarak kabul edildi. Bulgular: Çalışmamızda termine edilen 128 hastanın terminasyon endikasyonları belirlendi. Gebelik terminasyon endikasyonları: Missed abortus 32 (%25), santral sinir sistemi anomalileri 30 (%23,4), anhidramniyoz 28 (%21,8), kromozal anomaliler 11 (%8,5), kardiyak anomaliler 7 (%5,4), çoklu sistem anomalileri 6 (%4,6), kas iskelet anomalileri 5 (%3,9), gastrointestinal ve genitoüriner sistem anomalileri 5(%3,9), teratojen ilaç kullanımı ve radyasyona maruz kalma 4 (%3,1) bulundu. Grup 1 olgularda 48 saatte abortus oranı (%90,4) idi. Grup 2 olgularda 48 saatte başarı oranı ise (%92,3) bulundu. Sonuç: İlk trimester ve ikinci trimesterde yapılan obstetrik ultrasonografi fetal yapısal anomalilerin tanısında en önemli yöntemdir. Santral sinir sistemi anomalileri fetal anomaliler içerisinde en büyük grubu oluşturmaktadır. Hastanemizde 10 (on) hafta ve üzeri gebelik sonlandırılmasında kullanılan mizoprostolün etkili ve güvenilir olduğu düşünülmektedir. Ancak, mizoprostol için etkili ve güvenilir uygulama şeklinin ve dozunun ne olması gerektiği konusunda henüz fikir birliğine varılabilmiş değildir.

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Comparison of Effectiveness and Patient Satisfaction of Vaginal Versus Oral Misoprostol in Treatment of Missed Miscarriage

Cited by 3 publications

References 15 publications

Study of Oral Versus Vaginal Misoprostol in the Management of Early Pregnancy Loss

Study of Oral Versus Vaginal Misoprostol in the Management of Early Pregnancy Loss

Comparison of the efficacy of sublingual, oral, and vaginal administration of misoprostol in the medical treatment of missed abortion during first trimester of pregnancy: A randomized clinical trial study

Evaluation of the Effectiveness of Intravaginal Misoprostol in Termination of Pregnancy

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