Management of Differentiated Thyroid Carcinomas

Fernández-Vañes, Laura; Llorente, José Luís; García-Cabo, Patricia; Menéndez, M J; Pedregal, Daniel; Rodrigo, Juan P.; López, Fernándo

doi:10.1016/j.otoeng.2018.03.008

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…In another series, there were 900 recurrence and cancer mortalities after total thyroidectomy in low-risk carcinomas; on the other hand, 93 contralateral recurrences were mentioned after hemithyroidectomy + radioactive iodine treatment (30). When our results are evaluated together with the literature data, it can be said that lobectomy intervention to the dominant lesion side, contralateral subtotal or near-total lobectomy are not the only optimal method but have a therapeutic for differentiated thyroid carcinomas that are considered to be in the low-risk group, however, the tendency to total thyroidectomy in highly invasive tumours (such as highly invasive follicular carcinoma) is a more appropriate option in terms of treatment efficacy.…”

Section: Discussion Discussionmentioning

confidence: 96%

“…Lower recurrence and higher survival rates are reported in patients receiving radioactive iodine therapy after total thyroidectomy compared to those undergoing total thyroidectomy only, regardless of the extent of the disease and the tumor histology (26,29). It is pointed out that if there is some thyroid tissue left after surgery, then I 131 administered will be primarily drawn by healthy thyroid tissue and thus it will be difficult for it to reach malignant cells which are the main target (27,30).…”

Section: Discussion Discussionmentioning

confidence: 99%

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What Should We Prefer in the Surgical Management of Differentiated Thyroid Carcinomas?

Çiftçi¹

2019

SGO

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Aim: The study evaluates the results of surgical procedures performed in patients with differentiated thyroid carcinoma. There are many discussions regarding the optimal surgical treatment of differentiated thyroid carcinoma; their focal point is the type or extent of thyroidectomy. Material and Method: We performed a retrospective analysis on 85 patients diagnosed with differentiated thyroid carcinoma, treated in the period July 2007-April 2017. The average age the patients, consisting of 15 males and 70 females, was of 41 (17-85) years. The gross findings at operation and the prognostic factors such as patients' age, tumour size, local invasion, nodal involvement and the presence of distant metastasis were taken into account when deciding on the type of thyroidectomy, and cervical neck dissection. Results: The most prominent symptom was the existence of a cervical mass (85%); fineneedle aspiration biopsy (FNAB) was performed in 73 patients and revealed a diagnostic accuracy in 61 patients (72%). Histological examination confirmed papillary carcinoma in 76 patients, follicular carcinoma in 8 patients and medullary carcinoma in 1 patient. When the diagnosis was established, 19 patients had palpable neck lymph nodes, and 25 patients had a local invasion to surrounding structures. While total thyroidectomy was performed in 71 (83.5%) patients, 11 (12.4%) patients underwent lobectomy and subtotal thyroidectomy, and 3 (3.5%) patients underwent lobectomy and near-total lobectomy. Modified neck dissection was added to 13 patients who underwent total thyroidectomy. No operative mortality was observed, and the cancer-related mortality rate was 10.2%. Temporary and permanent hypoparathyroidism rates were 5% and 1.1%, respectively. Temporary and permanent recurrent nerve paralysis was observed to be of 3% and 0%, respectively. Conclusion: The selection of treatment for differentiated thyroid carcinoma should be made based on risk factors. All procedures such as lobectomy + subtotal lobectomy, near-total thyroidectomy, and total thyroidectomy are selected in safe conditions. In addition to total thyroidectomy, modified neck dissection should also be considered for patients with differentiated thyroid carcinoma with nodal involvement.

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Section: Discussion Discussionmentioning

confidence: 96%

Section: Discussion Discussionmentioning

confidence: 99%

What Should We Prefer in the Surgical Management of Differentiated Thyroid Carcinomas?

Çiftçi¹

2019

SGO

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“…Hashimoto's disease (chronic lymphocytic thyroiditis or autoimmune thyroiditis) is one of the most common inflammatory thyroid disorders, with an incidence of approximately 0.3 to 1.5 per 1000 people (1). This chronic thyroid problem is a type of autoimmune disease involving various cells and antibodies involved in the immune response (2). It is the most common cause of early hypothyroidism and non-endemic goiter, with a 10 to 15 times incidence rate in women than in men (3).…”

Section: Introductionmentioning

confidence: 99%

Clinico-pathological Features and Survival Time of Papillary Thyroid Carcinoma in Patients With and Without Hashimoto’s Thyroiditis: A Cross-sectional Study

Moghimi,

Shamsadini Ezabadi,

Mortazavi Zadeh

et al. 2022

Crescent J Med Biol Sci

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Objectives: Researchers have reported different results regarding the association between Hashimoto’s disease and papillary thyroid carcinoma (PTC). Some believe that the coexistence of these diseases can lead to fewer tumor invasion and recurrence rates. This study evaluated the clinico-pathological features and survival time of PTC in patients with and without Hashimoto’s thyroiditis. Materials and Methods: In this cross-sectional study, medical records of 251 participants who underwent total or subtotal thyroidectomy due to PTC from 2012 to 2019 were reviewed. The clinico-pathological features of participants, such as age, gender, tumor stage, tumor size, lymph node involvement, metastasis, capsular invasion, single or multi-focal tumor status, and survival time were recorded from their medical records and pathology report and compared in two groups with and without Hashimoto’s thyroiditis. Results: From 251 participants, 92 (36.6%) had Hashimoto’s thyroiditis, whereas 159 (63.4%) did not show any signs of this disease. Fifteen participants in the Hashimoto group and 46 in the non-Hashimoto group had a recurrence. Although there were no significant differences between the two groups in the term of recurrence rate (P = 0.08), the mean survival time was significantly difference between the two groups (69.03 and 58.78, respectively; P = 0.038) Conclusions: Results of the study revealed that Hashimoto’s thyroiditis could increase the survival time of patients with PTC.

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Simultaneous occurrence of follicular and papillary thyroid carcinomas in same thyroid lobe: A case series of six patients from Qatar

Abdelaal

Ansari

Abusabeib

et al. 2020

International Journal of Surgery Case Reports

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Highlights Simultaneous occurrence of papillary and follicular thyroid carcinomas in the same lobe are very rare. First case series of simultaneous occurrence of these two types of thyroid cancer in the Middle East and North Africa Region. Endocrinologists and pathologists should be aware of and vigilant to this variety. Occurrence of both types together shifts patients from low risk to intermediate or high risk which may reflect on management.

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Management of Differentiated Thyroid Carcinomas

Cited by 3 publications

References 20 publications

What Should We Prefer in the Surgical Management of Differentiated Thyroid Carcinomas?

What Should We Prefer in the Surgical Management of Differentiated Thyroid Carcinomas?

Clinico-pathological Features and Survival Time of Papillary Thyroid Carcinoma in Patients With and Without Hashimoto’s Thyroiditis: A Cross-sectional Study

Simultaneous occurrence of follicular and papillary thyroid carcinomas in same thyroid lobe: A case series of six patients from Qatar

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