Abstract:BackgroundGiven the importance of surgical debridement in healing of diabetic foot ulcers, effective local anaesthesia is required to manage the related extreme pain. The pharmaceutical proprietary products currently available have low concentrations and do not exceed 5% w/w local anaesthetic.ObjectiveFormulation design of a lidocaine cream of 25% and assessment of the intrinsic stability.MethodsA cream pharmaceutical form was chosen for its ability to cross the skin barrier and effectively anaesthetise the sk… Show more
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