Telemedicine has emerged as a transformative force in healthcare, offering convenience, accessibility, and the potential for improved patient outcomes. This chapter explores the critical pillars of telemedicine: compliance, data security, and patient consent. The security challenges in telemedicine, including data breaches and the imperative need for encryption, serve as foundational concerns. Robust security practices, alongside strategies to obtain informed patient consent, are essential to ensure that sensitive medical data is protected and used ethically. Digital transformation brings both advantages and vulnerabilities. While telemedicine enhances efficiency, decision-making, and patient experiences, it also demands a delicate balance between innovation and data protection. In conclusion, the potential of telemedicine is undeniable, but it must be navigated responsibly. This chapter sheds light on the multifaceted challenges and opportunities in telemedicine and emphasizes the importance of continuous research and adaptability in ensuring patient-centered care in the digital age.