Management of celiac trunk and superior mesenteric artery synchronous aneurysms as an extremely rare manifestation of Wegener granulomatosis

Mozaffar, Mohammad; Shahrbaf, Mohammad Amin; Azimi, Behzad; Arabzadeh, AmirAhmad

doi:10.1016/j.jvscit.2019.05.005

Cited by 5 publications

(2 citation statements)

References 14 publications

(19 reference statements)

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“…Inflammation is an immune system reaction to harmful factors that account for the induction of several cellular signals. Excessive generation of various pro-inflammatory cytokines during the process worsens this response ( 74 , 75 ). Studies have demonstrated that DM can impair reproductive organs by inducing inflammation.…”

Section: Discussionmentioning

confidence: 99%

A systematic review on the role of melatonin and its mechanisms on diabetes-related reproductive impairment in non-clinical studies

Armandeh

Bameri²,

Haghi‐Aminjan³

et al. 2022

Front. Endocrinol.

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BackgroundDiabetes-induced reproductive complications can lead to subfertility and infertility, raising the need to protect reproductive organs. There are limited medications used to improve reproductive health in diabetic patients. Melatonin, mainly produced by the pineal gland, may improve diabetes-associated reproductive complications through various mechanisms and may be a preferred candidate to protect the reproductive system. The present review aims to elucidate the underlying mechanisms of melatonin’s effect on the reproductive system adversely affected by diabetes mellitus (DM).MethodsA comprehensive systematic literature electronic search was done using the PRISMA guidelines. Web of Science, PubMed, Embase, and Scopus were searched for publications up to June 2022. Search terms were selected based on the study purpose and were explored in titles and abstracts. After screening, out of a total of 169 articles, 14 pertinent articles were included based on our inclusion and exclusion criteria.ResultsThe results of studies using rats and mice suggest that DM adversely affects reproductive tissues, including testes and epididymis, prostate, corpus cavernosum, and ovary leading to alterations in histological and biochemical parameters compared to the normal groups. Treatment with melatonin improves oxidative stress, blocks apoptosis induced by endoplasmic reticulum stress and caspase activation, reduces pro-inflammation cytokines, and enhances steroidogenesis.ConclusionMelatonin exerted a protective action on the impaired reproductive system in in-vivo and in-vitro models of DM. The topic has to be followed up in human pregnancy cases that will need more time to be collected and approved.

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Section: Discussionmentioning

confidence: 99%

A systematic review on the role of melatonin and its mechanisms on diabetes-related reproductive impairment in non-clinical studies

Armandeh

Bameri²,

Haghi‐Aminjan³

et al. 2022

Front. Endocrinol.

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show abstract

“…Inflammaging refers to the chronic, low-grade inflammation that characterizes aging. There are many mechanisms suggested for inflammation, and one of the most important ones is oxidative stress [35,36]. It is proven that inflammation is one of the leading causes of aging and can play an important role in age-related disease pathogenesis [37].…”

Section: Discussionmentioning

confidence: 99%

Vinpocetine Effect on the Juncture of Diabetes and Aging: An in-vitro study

et al. 2021

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Background The rapid-growing population of diabetic patients and the elderly are among the direst challenges that the science of medicine is facing today. Targeting these two challenges can shed light on new means to control and ideally reverse this trend. In this experiment, Vinpocetine’s effect on aged pancreatic beta-cell functions in correlation with oxidative stress was studied. Methods Islet cells were isolated from the pancreas of aged rats and exposed to Vinpocetine, dissolved in acetone and RPMI, for 48 h. Then, senescence-associated molecular parameters, including P16 and P38 gene expressions and β-galactosidase activity, were investigated along with diabetic and inflammation markers. Results Experimental results showed that Vinpocetine could significantly increase aged islets insulin secretion and also make a meaningful reduction in oxidative stress markers. This drug can also decrease expression levels of P16 and P38, the primary genes responsible for the aging pathway. TNF-α, IL-6, and NF-κB expressions were also reduced noticeably after treatment with Vinpocetine. Conclusion The current study showed that Vinpocetine, a derivative of the secondary plant metabolite called Vincamine, could break this vicious cycle of oxidative stress and aging by reducing oxidative stress and inflammation, thus inhibiting cellular aging.

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Senolytic Effect of Cerium Oxide Nanoparticles (CeO2 NPs) by Attenuating p38/NF-кB, and p53/p21 Signaling Pathways

et al. 2021

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Management of celiac trunk and superior mesenteric artery synchronous aneurysms as an extremely rare manifestation of Wegener granulomatosis

Cited by 5 publications

References 14 publications

A systematic review on the role of melatonin and its mechanisms on diabetes-related reproductive impairment in non-clinical studies

A systematic review on the role of melatonin and its mechanisms on diabetes-related reproductive impairment in non-clinical studies

Vinpocetine Effect on the Juncture of Diabetes and Aging: An in-vitro study

Senolytic Effect of Cerium Oxide Nanoparticles (CeO2 NPs) by Attenuating p38/NF-кB, and p53/p21 Signaling Pathways

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