Senolytic Effect of Cerium Oxide Nanoparticles (CeO2 NPs) by Attenuating p38/NF-кB, and p53/p21 Signaling Pathways

Haghi‐Aminjan, Hamed; Baeeri, Maryam; Khalid, Madiha; Rahimifard, Mahban; Mahdizadeh, Elaheh; Shayesteh, Mohammad Reza; Abdollahi, Mohammad

doi:10.1007/s10876-021-02152-y

Cited by 6 publications

(3 citation statements)

References 69 publications

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“…Oxidative stress may activate pathways, such as TNF-α/NF-κB, promote inflammation, and cause Th1/Th2 imbalance . Meanwhile, CeO 2 as a senolytic or inhibitor of senescence can attenuate the senescence-inducing signal transduction pathways, i.e., p38/NF-rB and p53/p21 . These results indicated that CeO 2 /BSA nanoclusters can regulate the Th1/Th2 signaling pathway by scavenging ROS, thus improving pulmonary vascular remodeling.…”

Section: Resultsmentioning

confidence: 88%

CeO₂/Bovine Serum Albumin Nanoclusters with Robust Reactive Oxygen Species Scavenging and Improved Endothelial Dysfunction Abilities for the Treatment of Pulmonary Hypertension

Zhao,

Wu,

et al. 2024

ACS Appl. Nano Mater.

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Endothelial dysfunction is one of the main pathogenetic mechanisms of pulmonary hypertension (PH). In the pathological microenvironment, excess reactive oxygen species (ROS) further induce pulmonary microvascular endothelial cell (PMEC) dysfunction. Recently, there has been an extreme lack of drugs that specifically target and eliminate ROS within the microenvironment. Although some nanomaterials are known as effective ROS-scavenging agents and can further alleviate disease progression, few nanomaterials have been reported in the endothelial dysfunction of PH. Based on the above situation, we synthesized a kind of novel nanoclusters (cerium dioxide/bovine serum albumin, CeO 2 /BSA), which can not only effectively scavenge ROS but also inhibit hypoxia-induced PMEC overproliferation, migration, and apoptosis resistance. CeO 2 /BSA nanoclusters were proved to be enriched in the lung, which effectively relieved pulmonary vascular remodeling, reduced the pressure of the pulmonary artery, and finally significantly improved cardiac function. Through in-depth mechanism analysis, we found that CeO 2 /BSA nanoclusters may be involved in Th1 and Th2 differentiation pathways mainly by effectively scavenging high levels of ROS in the pulmonary artery. In addition, the good biocompatibility of CeO 2 /BSA nanoclusters increased the possibility of their clinical application in the treatment of PH. In conclusion, this work provides a novel and effective solution to improve the dilemma of the ROS target and elimination in the treatment of PH.

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Section: Resultsmentioning

confidence: 88%

CeO₂/Bovine Serum Albumin Nanoclusters with Robust Reactive Oxygen Species Scavenging and Improved Endothelial Dysfunction Abilities for the Treatment of Pulmonary Hypertension

Zhao,

Wu,

et al. 2024

ACS Appl. Nano Mater.

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“…Albeit, when accumulated, senescent cells may exacerbate the condition in a negative way. ROS also induce p53/p38, another pathway leading to cell senescence (Poulsen et al, 2014;Ribezzo et al, 2016;Pyo et al, 2020;Haghi-Aminjan et al, 2021). Numerous researches have investigated the anti-cancer benefits of resveratrol in all stages of cancer initiation, promotion and progression (Schmitt, 2007;Baxter, 2008;You et al, 2019;Pyo et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Combination therapy of cisplatin and resveratrol to induce cellular aging in gastric cancer cells: Focusing on oxidative stress, and cell cycle arrest

et al. 2023

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Background: As a medical dilemma, gastric cancer will have 7.3 million new cases in 2040. Despite the disease’s high economic and global burden, conventional chemotherapy regimens containing cisplatin have insufficient effectiveness and act non-specifically, leading to several adverse drug reactions To address these issues, the biological efficacy of the cisplatin-resveratrol combination was tested.Methods: To find IC50, gastric adenocarcinoma cells (AGS) were exposed to different concentrations of resveratrol and cisplatin. Anti-cancer and anti-metastatic effects of 100 M resveratrol with concentrations of cisplatin (25, 50, and 100 g/ml) were studied by assessing ß-galactosidase and telomerase activities, senescence and migration gene expression, reactive oxygen species (ROS) level, and cell cycle arrest.Results: Co-administration of cisplatin and resveratrol increased ß-galactosidase activity, ROS level as a key marker of oxidative stress, p53, p38, p16, p21, and MMP-2 gene expression, and induced G0/G1 cell cycle arrest. Additionally, telomerase activity, pro-inflammatory gene expression, and cell invasion were suppressed. The best results were achieved with 100 g/ml cisplatin co-administered with resveratrol.Conclusion: The current study proved the synergistic effect of the cisplatin-resveratrol combination on suppressing metastasis and inducing apoptosis and cell senescence through targeting P38/P53 and P16/P21 pathways. Such promising results warrant translation to animal models and the clinic. This may lead to cost-effective, available, and accessible treatment regimens with targeted action and the fewest ADRs.

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Exploring the anti-aging effect of dextran and polyethylene glycol-coated cerium oxide nanoparticles in erythrocytes

Yadav,

Bhagat,

Singh

et al. 2024

International Journal of Biological Macromolecules

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Senolytic Effect of Cerium Oxide Nanoparticles (CeO2 NPs) by Attenuating p38/NF-кB, and p53/p21 Signaling Pathways

Cited by 6 publications

References 69 publications

CeO₂/Bovine Serum Albumin Nanoclusters with Robust Reactive Oxygen Species Scavenging and Improved Endothelial Dysfunction Abilities for the Treatment of Pulmonary Hypertension

CeO₂/Bovine Serum Albumin Nanoclusters with Robust Reactive Oxygen Species Scavenging and Improved Endothelial Dysfunction Abilities for the Treatment of Pulmonary Hypertension

Combination therapy of cisplatin and resveratrol to induce cellular aging in gastric cancer cells: Focusing on oxidative stress, and cell cycle arrest

Exploring the anti-aging effect of dextran and polyethylene glycol-coated cerium oxide nanoparticles in erythrocytes

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Senolytic Effect of Cerium Oxide Nanoparticles (CeO2 NPs) by Attenuating p38/NF-кB, and p53/p21 Signaling Pathways

Cited by 6 publications

References 69 publications

CeO2/Bovine Serum Albumin Nanoclusters with Robust Reactive Oxygen Species Scavenging and Improved Endothelial Dysfunction Abilities for the Treatment of Pulmonary Hypertension

CeO2/Bovine Serum Albumin Nanoclusters with Robust Reactive Oxygen Species Scavenging and Improved Endothelial Dysfunction Abilities for the Treatment of Pulmonary Hypertension

Combination therapy of cisplatin and resveratrol to induce cellular aging in gastric cancer cells: Focusing on oxidative stress, and cell cycle arrest

Exploring the anti-aging effect of dextran and polyethylene glycol-coated cerium oxide nanoparticles in erythrocytes

Contact Info

Product

Resources

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CeO₂/Bovine Serum Albumin Nanoclusters with Robust Reactive Oxygen Species Scavenging and Improved Endothelial Dysfunction Abilities for the Treatment of Pulmonary Hypertension

CeO₂/Bovine Serum Albumin Nanoclusters with Robust Reactive Oxygen Species Scavenging and Improved Endothelial Dysfunction Abilities for the Treatment of Pulmonary Hypertension