Management of Bleeding in Surgery and Intensive Care

Calatzis, Andreas; Schramm, W; Spannagl, Michael

doi:10.1007/978-3-642-59383-3_7

Cited by 2 publications

(5 citation statements)

References 29 publications

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“…The TPI is calculated from the CFT and MCF thromboelastometric parameters and represents a robust measure of thrombogenic potential [8,10]. In our study, TPI was able to differentiate severe from nonsevere patients and healthy controls in the EXTEM, INTEM and NATEM assays.…”

Section: Plos Onementioning

confidence: 74%

“…6. The thrombodynamic potential index (TPI) was calculated as [(100 x MCF)/(100-MCF)]/ CFT [10]. In the FIBTEM assay, only MCF was considered, provided that the main function of this test is to analyze the participation of fibrinogen in clot firmness.…”

Section: Pregnancymentioning

confidence: 99%

“…In this sense, viscoelastic methods traditionally used to monitor hemorrhagic disturbances have emerged as a possible tool for assessing the hemostasis profile in the thrombotic pole of blood coagulation disorders [8,9]. Indeed, reduced clotting time (CT) and increased maximum clot firmness (MCF) have been used to characterize hypercoagulability conditions [10][11][12]. In this scenario, the thrombodynamic potential index (TPI) [10] constitutes an alternative parameter for monitoring the risk of thromboembolic events by representing the global coagulation process [8,9,13].…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, reduced clotting time (CT) and increased maximum clot firmness (MCF) have been used to characterize hypercoagulability conditions [10][11][12]. In this scenario, the thrombodynamic potential index (TPI) [10] constitutes an alternative parameter for monitoring the risk of thromboembolic events by representing the global coagulation process [8,9,13].…”

Section: Introductionmentioning

confidence: 99%

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Thromboelastometry demonstrates endogenous coagulation activation in nonsevere and severe COVID-19 patients and has applicability as a decision algorithm for intervention

et al. 2022

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In patients with severe forms of COVID-19, thromboelastometry has been reported to display a hypercoagulant pattern. However, an algorithm to differentiate severe COVID-19 patients from nonsevere patients and healthy controls based on thromboelastometry parameters has not been developed. Forty-one patients over 18 years of age with positive qRT-PCR for SARS-CoV-2 were classified according to the severity of the disease: nonsevere (NS, n = 20) or severe (S, n = 21). A healthy control (HC, n = 9) group was also examined. Blood samples from all participants were tested by extrinsic (EXTEM), intrinsic (INTEM), non-activated (NATEM) and functional assessment of fibrinogen (FIBTEM) assays of thromboelastometry. The thrombodynamic potential index (TPI) was also calculated. Severe COVID-19 patients exhibited a thromboelastometry profile with clear hypercoagulability, which was significantly different from the NS and HC groups. Nonsevere COVID-19 cases showed a trend to thrombotic pole. The NATEM test suggested that nonsevere and severe COVID-19 patients presented endogenous coagulation activation (reduced clotting time and clot formation time). TPI data were significantly different between the NS and S groups. The maximum clot firmness profile obtained by FIBTEM showed moderate/elevated accuracy to differentiate severe patients from NS and HC. A decision tree algorithm based on the FIBTEM-MCF profile was proposed to differentiate S from HC and NS. Thromboelastometric parameters are a useful tool to differentiate the coagulation profile of nonsevere and severe COVID-19 patients for therapeutic intervention purposes.

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Section: Plos Onementioning

confidence: 74%

Section: Pregnancymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Thromboelastometry demonstrates endogenous coagulation activation in nonsevere and severe COVID-19 patients and has applicability as a decision algorithm for intervention

et al. 2022

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“…Coagulopathy on arrival in the ED has been shown to be an independent prognostic indicator and patients whose coagulopathy is treated aggressively have increased survival [10]. Work in elective vascular, cardiothoracic and organ transplantation surgery has also shown that both the early detection and management of coagulopathy [11], and the use of ROTEM [12], result in a better outcome. Most of the work already published on the use of ROTEM in the ED has focused on trauma patients.…”

Section: Importancementioning

confidence: 99%