2015
DOI: 10.5489/cuaj.2894
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Management of advanced kidney cancer: Canadian Kidney Cancer Forum consensus update

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Cited by 18 publications
(14 citation statements)
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References 49 publications
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“…With disease progression following second-line treatment, enrollment into a clinical trial is recommended where possible. 1,14 There is minimal high-quality evidence to guide choice of therapy in this setting, as the majority of clinical trials have been conducted in the first-or second-line setting.…”
Section: Third-line Treatmentmentioning
confidence: 99%
See 1 more Smart Citation
“…With disease progression following second-line treatment, enrollment into a clinical trial is recommended where possible. 1,14 There is minimal high-quality evidence to guide choice of therapy in this setting, as the majority of clinical trials have been conducted in the first-or second-line setting.…”
Section: Third-line Treatmentmentioning
confidence: 99%
“…In Canada, a VEGF receptor-tyrosine kinase inhibitor (VEGFR-TKI) is the widely accepted treatment of choice in the first-line setting, namely sunitinib or pazopanib, for patients with mRCC. The mTOR inhibitor temsirolimus is a recognized option in select situations, 1 although rarely used. Following progression in the first-line setting, the VEGFR-TKI axitinib or the mTOR inhibitor everolimus are the recommended second-line options in Canada; 1 however, three new options with demonstrated efficacy in the second-line setting have arisen -nivolumab (a programmed death 1 [PD-1] inhibitor), cabozantinib (a TKI that inhibits VEGFR, MET, and AXL), and the combination of lenvatinib (a VEGFR and fibroblast growth factor receptor [FGFR] TKI inhibitor) and everolimus.…”
Section: Introductionmentioning
confidence: 99%
“…Au premier plan, un examen du cancer du rein de stade avancĂ© par le RĂ©seau canadien de recherche en cancer du rein effectuĂ© Ă  la suite du 6 e Forum canadien sur le cancer du rein tenu Ă  Toronto plus tĂŽt cette annĂ©e 1 . Ces Ă©noncĂ©s et recommandations actualisĂ©s font Ă©tat de plusieurs essais randomisĂ©s et Ă©tudes d'observation rĂ©cents fournissant des donnĂ©es sur la prise en charge du cancer du rein localement avancĂ© et mĂ©tastatique, avec un aperçu du point de vue canadien.…”
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“…7 During the 2017 conference, the advanced disease management consensus statement, published in 2015, was reviewed and updated using the same process. 5 The field of systemic therapy is evolving quickly and the recommendations made in this document reflect the available evidence at the time the consensus conference participants reached their conclusions (February 4, 2017). As new data becomes available, treatment options will invariably change.…”
Section: Introductionmentioning
confidence: 99%