Management of adult spontaneous spondylodiscitis and its rising incidence

Sur, Amitava; Tsang, K; Brown, Mark D.; Tzerakis, Nikolaos

doi:10.1308/rcsann.2015.0009

Cited by 58 publications

(46 citation statements)

References 12 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the case of spinal epidural abscess, neurological deficits also typify the classical presenting symptomatology but imply advanced disease. [10][11][12] However, the overall incidence is proportionally higher in older than in younger patients and is increasing. 1,2,5,7,8 Rates of general infection and sepsis increase with age 9 and also when considering spinal infections.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6] However, clinical presentations may commonly be nonspecific and not conform to these expected patterns. 1,10,11,[13][14][15] Delayed or missed diagnosis results in poorer outcomes, including significant morbidity, mortality and functional impairment. 9,10 Spinal infections are relatively uncommon, with incidence approximating 0.2-3.7/100 000 for spondylodiscitis and 2-20/100 000 hospital admissions for spinal epidural abscesses.…”

Section: Introductionmentioning

confidence: 99%

“…9,10 Spinal infections are relatively uncommon, with incidence approximating 0.2-3.7/100 000 for spondylodiscitis and 2-20/100 000 hospital admissions for spinal epidural abscesses. [10][11][12] However, the overall incidence is proportionally higher in older than in younger patients and is increasing. 1,10,11,[13][14][15] Delayed or missed diagnosis results in poorer outcomes, including significant morbidity, mortality and functional impairment.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Spinal infections in older people: an analysis of demographics, presenting features, microbiology and outcomes

Amadoru

Lim

Tacey

et al. 2017

Internal Medicine Journal

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Spinal infections in older people: an analysis of demographics, presenting features, microbiology and outcomes

Amadoru

Lim

Tacey

et al. 2017

Internal Medicine Journal

View full text Add to dashboard Cite

show abstract

“…When the literature is examined; there are studies reporting that the incidence of spondylodiscitis has increased and accordingly the intravenous antibiotics have been used (22). However, the rational use of drugs is important, and it is also important to apply the right drug at the right time.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Neutrophil-to-lymphocyte ratio as a marker of inflammatory response in Spondylodiscitis

Karaarslan¹,

Yılmaz²,

Akgün³

et al. 2018

J Turgut Ozal Med Cent

View full text Add to dashboard Cite

Aim: Spondylodiscitis, if not diagnosed on time, can cause morbidity or mortality at high rates. This study was carried out with the aim of testing the hypothesis that "neutrophil-to-lymphocyte ratio can be used" especially in cases where it is difficult to diagnose spondylodiscitis. Material and Methods: This study involved 24 patients admitted to the State Hospital of Ministry of Health and Namik Kemal University for spondylodiscitis between January2014 and June2017. After excluding the cases that did not meet the inclusion criteria (n=6), the remaining cases (n=24) were referred to as the study group. A control group was created from healthy volunteers (n=24) who applied for routine physical checkups at the clinic between the same dates and who were similar in terms of age, sex, and body mass index to the study group. Hemogram parameters of the cases in both groups; white blood cell, C-reactive protein, erythrocyte sedimentation rate, and neutrophil-to-lymphocyte ratio were statistically compared. Results: Patients in the spondylodiscitis group, compared to healthy volunteers had statistically significant neutrophil-to-lymphocyte ratio value. Conclusion: Especially in cases where the diagnosis of spondylodiscitis is not assured, the neutrophil-to-lymphocyte ratio parameter, which is less costly than other diagnostic methods and the analysis results of which can be obtained in a shorter time, may be used to support clinical diagnosis.

show abstract

“…Spontaneous infectious spondylodiscitis (SIS), caused by the hematogenous spread of bacteria, is a relatively rare disease. However, a rise in the incidence of SIS has recently been noticed due to increasing life expectancy, use of endovascular devices, diabetes mellitus, and HIV [1, 2]. …”

Section: Introductionmentioning

confidence: 99%

First report on treating spontaneous infectious spondylodiscitis of lumbar spine with posterior debridement, posterior instrumentation and an injectable calcium sulfate/hydroxyapatite composite eluting gentamicin: a case report

2016

View full text Add to dashboard Cite

BackgroundSpontaneous infectious spondylodiscitis is a rare, but serious disease with the risk of progressive neurological impairment. The surgical approach to spontaneous infectious spondylodiscitis is in most cases an anterior debridement and fusion, often in staged surgeries. Here we report a case of single-stage posterior debridement and posterior instrumented fusion in combination with an injectable calcium sulfate/hydroxyapatite composite eluting gentamicin.Case presentationA 59-year-old Caucasian man presented with a 6-week history of lumbar pain without sensory or motor disorders of his lower extremities. A magnetic resonance imaging scan of his lumbar spine in T2-weighted sequences showed a high signal of the intervertebral disc L4/L5 and in T1-weighted sequences an epidural abscess at the posterior wall of L4. Additional computed tomography imaging revealed osteolytic destruction of the base plate of L4 and the upper plate of L5. Antibiotic therapy was started with intravenous ciprofloxacin and clindamycin. We performed a posterior debridement via a minimally invasive approach, a posterior percutaneous stabilization using transpedicular screw-rod instrumentation and filled the intervertebral space with an injectable calcium sulfate/hydroxyapatite composite which elutes a high concentration of gentamicin. The patient’s lower back pain improved quickly after surgery and no recurrence of infection has been noticed during the 1-year follow-up. Computed tomography at 11 months shows complete bony fusion of L4 and L5.ConclusionsAn injectable calcium sulfate/hydroxyapatite composite releasing a high level of gentamicin can support the surgical treatment of spondylodiscitis in combination with posterior debridement and transpedicular screw-rod instrumentation.

show abstract

Management of adult spontaneous spondylodiscitis and its rising incidence

Cited by 58 publications

References 12 publications

Spinal infections in older people: an analysis of demographics, presenting features, microbiology and outcomes

Spinal infections in older people: an analysis of demographics, presenting features, microbiology and outcomes

Evaluation of Neutrophil-to-lymphocyte ratio as a marker of inflammatory response in Spondylodiscitis

First report on treating spontaneous infectious spondylodiscitis of lumbar spine with posterior debridement, posterior instrumentation and an injectable calcium sulfate/hydroxyapatite composite eluting gentamicin: a case report

Contact Info

Product

Resources

About