Management of Adenoid Cystic Carcinoma of the Breast: A Rare Cancer Network Study

Khanfir, K.; Kallel, A.; Villette, S.; Belkacémi, Yazid; Vautravers, Claire; Nguyen, Tan Dat; Miller, Robert C.; Li, Ye Xiong; Taghian, Alphonse G.; Boersma, Liesbeth; Poortmans, Philip; Goldberg, Hadassah; Vees, Hansjörg; Senkus, Elżbieta; Igdem, Sefik; Özşahin, Mahmut; Sozzi, Wendy Jeanneret

doi:10.1016/j.ijrobp.2010.12.008

Cited by 66 publications

(71 citation statements)

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“…They could be misdiagnosed, when a pathologist is provided with insufficient tissue specimens by core needle biopsy. The differential diagnosis of the solid (basaloid) sub-type of ACC comprises small cell carcinoma (neuroendocrine carcinoma), solid papillary carcinoma, metaplastic carcinoma, and malignant lymphoma (8). As observed in the present study, the initial diagnosis by core needle biopsy was small cell carcinoma, whereas the post-operative biopsy revealed the different diagnosis.…”

Section: Discussionsupporting

confidence: 66%

“…In contrast to ACC of salivary glands, perineural invasion rarely occurs in ACC of breast. Khanfir et al mentioned that only 5 out of 61 patients had perineural invasion and it was not considered a prognostic factor (8). In this study, perineural invasion was reported negative, too.…”

mentioning

confidence: 47%

“…ited studies compared to the invasive cribriform/tubular carcinomas, which are negative for both (8). IHC shows several similarities between ACC and other triple negative breast cancers, except for androgen receptors (AR), which are absent in ACC, but positive in TNBC and DCIS (9).…”

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confidence: 99%

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Male Adenoid Cystic Carcinoma of Breast

2017

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Introduction: Adenoid cystic carcinoma (ACC) of the breast is a rare tumor, especially observed in males. Case Presentation: We presented a 42-year-old man, initially diagnosed with small cell carcinoma (SCC) by core needle biopsy. He underwent breast modified radical mastectomy (MRM) and axillary lymph node dissection; his final histopathological diagnosis was ACC. After surgery, although the patient was recommended to have post-operative chemo-radiotherapy, he did not comply. The patient is on follow-up for more than a year with no recurrence until now. Conclusions: ACC of the breast is a rare malignancy with excellent prognosis and favorable tumor biology. It could be mistaken with triple negative breast cancer, ductal carcinoma in situ (DCIC), and small cell carcinoma.

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Section: Discussionsupporting

confidence: 66%

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confidence: 47%

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Male Adenoid Cystic Carcinoma of Breast

2017

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“…In contrast, adenoid cystic carcinoma of the breast is a special type of triple-negative basal-like breast carcinoma associated with excellent prognosis [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Angiogenesis in triple-negative adenoid cystic carcinomas of the breast

et al. 2011

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We compared microvascular density (MVD), lymph vessel density (LVD), and the expression of hypoxia pathway-associated proteins between primary triple-negative adenoid cystic carcinoma of the breast (TN-ACC) and grade-matched triple-negative breast carcinomas of no special type (TNBC). Twelve TN-ACC and 15 TNBC were investigated immunohistochemically for CD31, podoplanin (D2-40), von Hippel-Lindau protein (pVHL), and hypoxia-inducible factor-1alpha (HIF-1α) protein. All cases were lymph node negative (pN0). The study revealed a median MVD (CD31) of 34 vessels/mm(2) (mean ± SD, 41.33 ± 6.5/mm(2)) in the TN-ACC subgroup and a median of 55 microvessels (mean ± SD, 54.9 ± 6.3/mm(2)) in the TNBC subgroup. The median LVD (D2-40) was 10.5/mm(2) (mean ± SD, 11.9 ± 1.5/mm(2)) in the TN-ACC subgroup and 15.0/mm(2) (mean ± SD, 16.9 ± 2.5/mm(2)) lymph vessels in the TNBC subgroup. The differences were not statistically significant (P = 0.93, P = 0.67, respectively). pVHL was detectable in all TN-ACCs whereas two cases of TNBC had less than 5% of the positive cells. HIF-1α protein expression was significantly higher in the tumor cell population than in adjacent normal cells in both subgroups (P = 0.009 for TNBC and P = 0.028 for TN-ACC, respectively), but there was no significant difference between the two tumor groups. Up-regulation of the hypoxia-induced signaling is seen in both TN-ACC and grade-matched TNBC. Despite its perceived low malignant potential, TN-ACC of the breast does not differ in the number of blood and lymphatic vessels in comparison with the grade-matched TNBC. The reported biologic differences between TN-ACC and TNBC do not appear to result from neoangiogenesis.

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“…An open biopsy of the sentinel lymph node is recommended in the case of tumours larger than 3 cm, and in the case of the occurrence of other subtypes of invasive cancer [2,17].…”

Section: Treatmentmentioning

confidence: 99%

Adenoid cystic carcinoma of the breast

Olszewska¹,

Głuszek²

2017

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Adenoid cystic carcinoma is an invasive cancer accounting for less than 0.1% of all breast cancers. It most frequently occurs as a single, clearly defined, tender tumour. Mammographic and ultrasound images are non-characteristic and may be misinterpreted as benign change. This cancer shows no expression of ER, PGR, and HER-2 receptors; however, as opposed to triple-negative breast cancers, NST has a mild course and sporadically gives rise to metastases to locoregional lymph nodes and distant metastases. There is no consensus concerning the optimum treatment. The surgeries usually performed are lumpectomy with an open sentinel lymph node biopsy and mastectomy. However, considering the low probability of the presence of metastases in the lymph nodes, doubts arise pertaining to the justification for lymph node resection. Adjuvant radiotherapy is recommended after breast-conserving surgeries, especially with positive margins. The role of chemotherapy has not been well recognised, and hormone therapy is not recommended. StreszczenieRak gruczołowo-torbielowaty piersi jest nowotworem inwazyjnym stanowiącym poniżej 0,1% wszystkich raków piersi. Występuje najczęściej jako pojedynczy, dobrze odgraniczony, tkliwy guz. Obraz mammograficzny i ultrasonograficzny nie jest charakterystyczny, może być on błędnie interpretowany jako zmiana łagodna. Rak ten nie wykazuje ekspresji receptorów ER, PGR i HER-2, ale w przeciwieństwie do trójujemnych raków piersi NST ma łagodny przebieg, sporadycznie daje przerzuty do lokoregionalnych węzłów chłonnych i przerzuty odległe. Ze względu na niewielką częstość występowania tego nowotworu nie ma konsensusu dotyczącego optymalnego leczenia. Najczęściej wykonywane zabiegi to lumpektomia z otwartą biopsją węzłą wartowniczego i mastektomia. Jednak z uwagi na niewielkie prawdopodobieństwo obecności przerzutów w węzłach chłonnych pojawiają się wątpliwości dotyczące celowości resekcji węzłów chłonnych. Adiuwantową radioterapię zaleca się po wykonanych zabiegach oszczędzających, zwłaszcza przy dodatnich marginesach. Rola chemioterapii nie jest dobrze poznana, leczenie hormonalne nie jest zalecane.

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Management of Adenoid Cystic Carcinoma of the Breast: A Rare Cancer Network Study

Cited by 66 publications

References 20 publications

Male Adenoid Cystic Carcinoma of Breast

Male Adenoid Cystic Carcinoma of Breast

Angiogenesis in triple-negative adenoid cystic carcinomas of the breast

Adenoid cystic carcinoma of the breast

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