Management and Survival of Pleural Mesothelioma: A Record Linkage Study

Carioli, Greta; Bonifazi, Martina; Rossi, Marta; Zambelli, Alberto; Franchi, Matteo; Zocchetti, Carlo; Gasparini, Stefano; Corrao, Giovanni; Vecchia, Carlo La; Negri, Eva

doi:10.1159/000486578

Cited by 8 publications

(8 citation statements)

References 30 publications

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“…In the current study, the review of the pathology reports and a centre validation phase permitted to identify a large number of these surgical acts as larger biopsies and partial resections intended to reduce symptoms rather than having a curative intent. The resulting cure-intended radical surgery rates are more in agreement with those observed in other countries [9,25].…”

Section: Discussionsupporting

confidence: 87%

Real-life treatment practice for malignant pleural mesothelioma in Belgium

Rosskamp¹,

Macq²,

Nackaerts

et al. 2018

Lung Cancer

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Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer, for which treatment is often limited to palliative combination chemotherapy. Multimodality-therapy, including radical surgery, is largely restricted to clinical trials, leaving its benefit currently unclear.This study aimed to get a comprehensive view on real-world MPM treatment at the Belgian population level, to assess survival and to identify prognostic factors. Materials and MethodsThe study period covered the incidence years 2004-2012 (N=1,453). Starting from the Belgian Cancer Registry, additional information regarding patient characteristics, diagnosis and treatment was retrieved from multiple data sources.Adjusted cox proportional-hazard regression models using time-dependent covariates were performed to assess survival in relation to treatment patterns and centre volume. ResultsSixty-nine percent of patients underwent tumour-directed treatment, mostly cisplatinpemetrexed chemotherapy. Radical surgery was mainly performed in younger patients with epithelioid subtype.Centre volume, surgery and chemotherapy showed a positive relation with survival in univariable analyses, but only chemotherapy remained significantly relevant in multivariable analyses. Younger patients, females, and epithelioid subtypes also independently had a better survival. ConclusionThis large population-based study provides insights in MPM treatment practice in Belgium.Centre volume and surgery being related to survival in univariable analyses, only chemotherapy remained prognostic after adjustment.

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Section: Discussionsupporting

confidence: 87%

Real-life treatment practice for malignant pleural mesothelioma in Belgium

Rosskamp¹,

Macq²,

Nackaerts

et al. 2018

Lung Cancer

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“…It is the results of a unique collaborative effort including 26 registries from 12 of 21 Italian regions corresponding to 70% of the Italian population. Previous Italian studies analyzed survival of MPM patients with limited information on treatment and generally were focused on one region …”

Section: Discussionmentioning

confidence: 99%

Treatment patterns among patients with malignant pleural mesothelioma: An Italian, population‐based nationwide study

et al. 2020

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Background: Malignant pleural mesothelioma (MPM) is a rare cancer with a poor prognosis. Centralization of rare cancer in dedicated centers is recommended to ensure expertise, multidisciplinarity and access to innovation. In Italy, expert centers for MPM have not been identified in all regions. We aimed to describe the treatment patterns among MPM patients across different Italian regions and to identify factors associated with the treatment patterns across the regions. Methods: We performed an observational study on a random sample of 2026 MPM patients diagnosed in 2003-2008. We included 26 population-based registries covering 70% of the Italian population. To identify factors associated with treatment patterns, across the different regions, we fitted a multinomial logistic regression model adjusted by age, sex, stage, histology and hospital with thoracic surgical department. Results: MPM patients mostly received chemotherapy alone (41%) or no cancer-directed therapy (36%) especially the older patients. The first course of treatment for MPM patients differed across regions. Patients from Piedmont, Liguria and Campania were more likely to receive no cancer-directed therapy; those living in Tuscany and Sicily were more likely to get surgery; patients from Marche and Lazio were more likely to receive chemotherapy. These differences were not explained by age, sex, stage, histology and availability of a thoracic surgery department. Conclusions: There is limited expertise available and lack of a network able to maximize the expertise available may contribute to explaining the results of our study. Our findings support the need to ensure the appropriate care of all MPM patients in reorganizing the health care services. Key pointsSignificant findings of the study: MPM patients mostly received chemotherapy alone or no cancer-directed therapy especially the older patients. The first course of treatment for MPM patients differed across Italian regions. What this study adds: Differences in MPM clinical management are not explained by the age, stage, histology nor by the availability of a thoracic surgery department. Limited expertise for MPM contribute to explaining the unequal access to appropriate care for MPM patients in Italy.

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“…Furthermore, validation studies conducted on an Italian administrative database as regards to hospital discharge forms have shown a concordance between the clinical records and SDOs of about 95%,11 and with regard to obstetric data, for example, there were no missing values for birth weight, and gestational week of delivery was missing for less than 1% of forms 12…”

Section: Discussionmentioning

confidence: 97%

Pregnancy-associated cancers: frequency and temporal trends in Italy

Parazzini

Gadducci

Cicinelli

et al. 2019

Int J Gynecol Cancer

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ObjectiveLimited data are available on the frequency and time trends of pregnancy-associated cancers, particularly from Southern European countries. The aim of this study was to analyze the frequency and time trends of pregnancy-associated cancer in Italy.MethodsThis was a population-based linkage study using the regional hospital discharge forms database of four Italian regions with more than 17 million inhabitants. All resident women with a hospital discharge form reporting a birth or abortion in the time period under consideration were identified. The time period of the study was 2003–2015 for the Piemonte and Puglia region, 2006–2015 for the Tuscany region, and 2005–2015 for the Veneto region. Risk of developing a pregnancy-associated cancer was calculated as the ratio of the number of pregnancy-related cancers to the total number of pregnancies.ResultsA total of 2 297 648 pregnancies were identified. Overall, the pregnancy-associated cancer frequency was 134.8 per 100 000 pregnancies: the frequency ranged from 127.1 in Puglia to 157.3 in Tuscany. The frequency for 100 000 pregnancies was 66.4 in women aged <30 years; the risk increased with age, with a frequency of 275.6 among women aged 40+ years. Approximately two-thirds of cancers were associated with pregnancies resulting in a delivery and one-third with pregnancies resulting in a termination of pregnancy or spontaneous pregnancy loss. No clear trend emerged in the risk of pregnancy-associated cancer per 100 000 pregnancies and calendar year.ConclusionNo clear time trend was observed in the frequency of pregnancy-associated cancers in Italy during the last 10 years, the rates being 104, 164, and 130 per 100 000 pregnancies, respectively, in 2003, 2010, and 2015.

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Management and Survival of Pleural Mesothelioma: A Record Linkage Study

Cited by 8 publications

References 30 publications

Real-life treatment practice for malignant pleural mesothelioma in Belgium

Real-life treatment practice for malignant pleural mesothelioma in Belgium

Treatment patterns among patients with malignant pleural mesothelioma: An Italian, population‐based nationwide study

Pregnancy-associated cancers: frequency and temporal trends in Italy

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