Management and outcomes of cochlear implantation in patients with congenital cytomegalovirus (cCMV)-related deafness

Abstract

While the overall outcomes were mixed, most children in our cohort were found to benefit from cochlear implantation. Our data also highlight the significant neurodevelopmental comorbidities associated with cCMV and their negative impact on CI outcomes. With the recent advances in medical treatment, this underlines the importance of multidisciplinary management of these patients.

Cochlear implant performance in children deafened by congenital cytomegalovirus—A systematic review

“…The critical appraisal of the 30 studies is presented in Table . One study was a prospective cohort study, all other studies were retrospective studies.…”

“…Blinding was not performed in any of the studies, as no randomised controlled trials were included. Three studies were assessed as susceptible to selection bias, three were assessed as selective inclusion of non‐missing data in a retrospective cohort, all other 24 were assessed as having no selection bias …”

“…5,21,[24][25][26][27] In one study, a comparison could be distracted, yet no statistical analysis. 23 In seven studies, 32,34,38,41,[43][44][45] no comparison with a non-cCMV-group was made.…”

“…Except for one patient in one study 31 , all patients were <18 years old at time of implantation. In ten studies, all patients were measured at the same time post-implant 5,18,19,24,25,28,30,37,40,43 , in eighteen studies the time post-implant varied 13,20,22,23,26,27,29,[31][32][33]35,36,38,39,41,42,44,45 , and in two studies time post-implant was unclear. Blinding was not performed in any of the studies, as no randomised controlled trials were included.…”

“…Three studies were assessed as susceptible to selection bias 25,27,41 , three 18,37,43 were assessed as selective inclusion of non-missing data in a retrospective cohort, all other 24 were assessed as having no selection bias. 5,13,[19][20][21][22][23][24]26,[28][29][30][31][32][33][34][35][36][38][39][40]42,44,45 Finally, 12 studies 5,13,[18][19][20][21][22][23][24][25][26][27] were included in this review because all criteria for DoE were met and data were extractable.…”