Mammography screening: A major issue in medicine

Autier, Philippe; Boniol, Mathieu

doi:10.1016/j.ejca.2017.11.002

Cited by 129 publications

(126 citation statements)

References 252 publications

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“…Neglecting the results from RCTs and incidence‐based mortality studies with data on exposure to screening, investigators using trend analyses have concluded that modern mammography does not reduce the incidence of advanced breast cancers and only succeeds in detecting insignificant or slowly growing cancers that are not life threatening while missing more aggressive tumors that prove fatal . Instead, they argue, it is therapeutic advances that are principally or entirely responsible for the observed reductions in breast cancer mortality …”

Section: Discussionmentioning

confidence: 99%

The incidence of fatal breast cancer measures the increased effectiveness of therapy in women participating in mammography screening

Tabár

Dean

Chen

et al. 2018

Cancer

182

114

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Background Women and their health care providers need a reliable answer to this important question: If a woman chooses to participate in regular mammography screening, then how much will this choice improve her chances of avoiding a death from breast cancer compared with women who choose not to participate? Methods To answer this question, we used comprehensive registries for population, screening history, breast cancer incidence, and disease‐specific death data in a defined population in Dalarna County, Sweden. The annual incidence of breast cancer was calculated along with the annual incidence of breast cancers that were fatal within 10 and within 11 to 20 years of diagnosis among women aged 40 to 69 years who either did or did not participate in mammography screening during a 39‐year period (1977‐2015). For an additional comparison, corresponding data are presented from 19 years of the prescreening period (1958‐1976). All patients received stage‐specific therapy according to the latest national guidelines, irrespective of the mode of detection. Results The benefit for women who chose to participate in an organized breast cancer screening program was a 60% lower risk of dying from breast cancer within 10 years after diagnosis (relative risk, 0.40; 95% confidence interval, 0.34‐0.48) and a 47% lower risk of dying from breast cancer within 20 years after diagnosis (relative risk, 0.53; 95% confidence interval, 0.44‐0.63) compared with the corresponding risks for nonparticipants. Conclusions Although all patients with breast cancer stand to benefit from advances in breast cancer therapy, the current results demonstrate that women who have participated in mammography screening obtain a significantly greater benefit from the therapy available at the time of diagnosis than do those who have not participated.

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Section: Discussionmentioning

confidence: 99%

The incidence of fatal breast cancer measures the increased effectiveness of therapy in women participating in mammography screening

Tabár

Dean

Chen

et al. 2018

Cancer

182

114

View full text Add to dashboard Cite

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“…Summary relative risk estimates for all‐cause mortality are 0.99‐1.00 for both PSA screening and mammography with extremely tight confidence intervals . Recent observational data from population‐based screening programs in Norway, the Netherlands and Denmark also do not support any clinically meaningful breast cancer mortality benefit with mammography screening …”

Section: Screening Effectivenessmentioning

confidence: 97%

“…7,16 Recent observational data from population-based screening programs in Norway, 17 the Netherlands 18 and Denmark 19 also do not support any clinically meaningful breast cancer mortality benefit with mammography screening. 14 Lead time bias, the amount of time between the detection of a cancer through screening and its expected detection if no screening had been done, is the key artefact in the screening process. We acknowledge that from the standpoint of the patient, treating an advanced or metastatic tumour is not equivalent to treating a small, localized one.…”

Section: Early Detection Screeningmentioning

confidence: 99%

Time to abandon early detection cancer screening

Adami

Kalager

Valdimarsdóttir

et al. 2019

Eur J Clin Investigation

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“…Thus, there is a dire need to detect cancer early, when it is more responsive to treatment. 3 Mammography is a breast imaging method that employs low-dose x-rays to detect cancer early, thereby reducing the incidence of advanced cancers with poor prognosis. 3 Mammography screening in Nigeria is offered to women aged from 40 to 70 years, 4 although women under 40 years may also be invited for mammograms if they have a strong family history of breast cancer.…”

Section: Introductionmentioning

confidence: 99%

“…3 Mammography is a breast imaging method that employs low-dose x-rays to detect cancer early, thereby reducing the incidence of advanced cancers with poor prognosis. 3 Mammography screening in Nigeria is offered to women aged from 40 to 70 years, 4 although women under 40 years may also be invited for mammograms if they have a strong family history of breast cancer. 5 The efficacy of mammography in younger women is debatable (because of higher breast density).…”

Section: Introductionmentioning

confidence: 99%

Mammogram history in Nigerian women: Age-related risk factors for breast cancer and educational implications

Umeh

Ebubedike

et al. 2018

S. Afr. j. oncol.

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BackgroundBreast cancer accounts for 25% of diagnosed cancers and 20% of cancer-related mortality amongst women in sub-Saharan Africa. 1 Data from the International Agency for Research on Cancer suggest about 100 000 breast cancer cases are diagnosed annually in the African region, with the largest number of country-specific cases diagnosed in Nigeria (circa 14 000) yearly. 2 While the breast cancer incidence and mortality rates remain highest in fully industrialised nations, rates are rapidly increasing in developing countries. Thus, there is a dire need to detect cancer early, when it is more responsive to treatment. 3 Mammography is a breast imaging method that employs low-dose x-rays to detect cancer early, thereby reducing the incidence of advanced cancers with poor prognosis. 3 Mammography screening in Nigeria is offered to women aged from 40 to 70 years, 4 although women under 40 years may also be invited for mammograms if they have a strong family history of breast cancer. 5 The efficacy of mammography in younger women is debatable (because of higher breast density). 6 Nevertheless, missing a mammogram can significantly increase the likelihood of being diagnosed with cancer at a later stage. 7Background: Breast cancer accounts for 25% of diagnosed cancers and 20% of cancer-related mortality in women from sub-Saharan Africa. Given the early onset of breast cancer in African women, there is a need to better understand how age-related risk factors contribute to mammography uptake in this population.

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Mammography screening: A major issue in medicine

Cited by 129 publications

References 252 publications

The incidence of fatal breast cancer measures the increased effectiveness of therapy in women participating in mammography screening

The incidence of fatal breast cancer measures the increased effectiveness of therapy in women participating in mammography screening

Time to abandon early detection cancer screening

Mammogram history in Nigerian women: Age-related risk factors for breast cancer and educational implications

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