Mammographic morphology and distribution of calcifications in ductal carcinoma <i>in situ</i> diagnosed in organized screening

Hofvind, Solveig; Iversen, Barbro F; Eriksen, Liv; Styr, Bodil Margrethe; Kjellevold, Kjell H.; Kurz, Kathinka D.

doi:10.1258/ar.2011.100357

Cited by 70 publications

(58 citation statements)

References 24 publications

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“…Also, the investigations conducted in Norway, indicate that high grade DCIS has a typical segmental distribution (35). Holland et al stated that the amorphic, linear/branching microcalcifications were considered the most common ones in poorly differentiated DCIS, while the tendency towards clustered microcalcifications remained characteristic of the high-grade DCIS, evolving towards the invasive form (36).…”

Section: Discussionmentioning

confidence: 99%

Importance of microcalcifications in mammographic differentiation of the invasive ductal breast cancer and of the ductal carcinoma in situ

Sarac¹,

Nadrljanski²

2017

Med podmladak

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Introduction: Microcalcifications represent a significant and reliable sign of the presence of the malignant breast lesion. Aim: The aim of the paper is to radiologically evaluate the type and distribution of suspicious microcalcifications, in patients with invasive ductal carcinoma (IDC) and ductal carcinoma in situ (DCIS). Material and Methods: Retrospective analysis includes the evaluation of the type and distribution of suspicious microcalcifications, in patients with histologically verified malignant lesions: invasive ductal carcinoma (N1=40 pts.) and ductal carcinoma in situ (N2=40 pts.). Standardised mediolateral oblique and cranicaudal views were selected for the evaluation of the images, taken on the full-field digital mammograph (FFDM «Selenia», Institute of Oncology and Radiology of Serbia, Belgrade), on the dedicated workstation of the mammography unit, with the aid of the software for lesion evaluation. Results: Eight patients with invasive ductal carcinoma (20%) had no suspicious microcalcifications, as opposed to the patients with ductal in situ carcinoma, where all patients had suspicious microcalcifications (p<0.05). In the subgroup of patients with invasive ductal carcinoma, the most frequent type of microcalcifications included the fine pleomorphic calcifications (75%). In patients with ductal carcinoma in situ, amorphous (57.5%) and linear/ branching microcalcifications were more frequent than other types (55%). Conclusion:The results of this study show that the amorphous microcalcifications segmental distribution usually detected in the subgroup with DCIS, which coincides with published results. With acceptable sensitivity and specificity, amorphous microcalcifications and linear distribution segment represents a specific mammographic findings in the detection of DCIS.

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Section: Discussionmentioning

confidence: 99%

Importance of microcalcifications in mammographic differentiation of the invasive ductal breast cancer and of the ductal carcinoma in situ

Sarac¹,

Nadrljanski²

2017

Med podmladak

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“…It was the only sign for the reliable diagnosis of malignant lesions (Hofvind et al, 2011;Xue et al, 2011). This study shows that PND patients with breast calcifications had a higher risk of breast cancer than those without breast calcifications.…”

Section: Discussionmentioning

confidence: 99%

Retrospective analysis of pathologic nipple discharge

Fan

2015

Genet. Mol. Res.

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ABSTRACT. The cause of pathologic nipple discharge is mainly benign lesions, but there is still a possibility of malignancy. Pathologic nipple discharge may be the only or the first symptom of breast cancer. This study aimed to investigate the clinical factors associated with lesions in patients with pathologic nipple discharge using a retrospective analysis of clinical data in 207 cases. The univariate analysis showed that age >50 years, breast lumps, or breast calcifications were risk factors associated with breast cancer in nipple discharge patients (P < 0.05). Discharge characteristics, duration of disease, and identification of lesions had no clear clinical significance (P > 0.05). The multivariate analysis also showed that age >50 years, breast lumps, and breast calcifications were risk factors associated with breast cancer in nipple discharge patients (P < 0.05). Age, breast lumps, and breast calcifications had important clinical significance in identification of benign and malignant nipple discharge.

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“…As a result of the widespread utilization of screening mammography a shift has been seen in DCIS is now diagnosed more as more women opt for screening mammography 16,17 . There are specific mammographic findings most associated with shapes (amorphous, fine and coarse pleomorphic, and fine linear) and distributions (linear and segmental) of the calcifications that permit a reasonable sensitivity for detection of DCIS without an unreasonable decrease in specificity.…”

Section: Malignant Microcalcificationsmentioning

confidence: 99%

A Pathologists Purview of Breast Calcifications

Sankaye¹,

Kachewar²

2014

Cukurova Medical Journal

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Accumulation of calcium or calcium salts in breast parenchyma; where it does not belong naturally leads to an abnormality known as Breast Calcification. When such calcifications occur due mineral deposits in individuals with normal calcium levels, these are called as dystrophic calcifications. As against this, metastatic calcification is the term used when calcification occurs in otherwise normal tissue with elevated calcium levels. Although calcifications in breasts are reported with breast cancers; they can also be seen in benign conditions. They cannot be directly seen by the naked eye. Although sonomammography can demonstrate them many times; often the microcalcifications can go un-noticed. X-ray mammography is the best diagnostic tool to show them reliably; on which they appear as white specks or dots. This article puts forth a Pathologist`s purview of breast calcifications. ÖZETMeme parenkimasında biriken kalsiyum ya da kalsiyum tuzları doğal olmadığı gibi Meme Kalsifikasyonu olarak bilinen anormalliğe yolaçar. Böyle kalsifikasyonlar normal kalsiyum düzeyleriyle mineral depolarında ortaya çıktığı zaman bunlara distrofik kalsifikasyon adı verilir. Bundan farkli olarak normal dokularda kalsiyum düzeyinin artmasıy içinse Metastatik Kalsifikasyon terimi kullanılır.Meme kalsifikasyonları meme kanseriyle birlikte bildirilmelerine rağmen iyi huylu olarakda görülebilir. Bunlar çıplak gözle farkedilemeyebilir. Sonomamografiyle bir çok kez görülmelerine rağmen, mikrokalsifikasyonlar farkedilmez. Bu durumlar için en iyi tanı X-RAY Mamografidir ki burada beyaz leke ya da nokta şeklinde görülürler. Bu makalede bir Patologun Meme Kalsifikasyonuyla ilgili görüşüne yer verilmiştir.

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Mammographic morphology and distribution of calcifications in ductal carcinoma in situ diagnosed in organized screening

Cited by 70 publications

References 24 publications

Importance of microcalcifications in mammographic differentiation of the invasive ductal breast cancer and of the ductal carcinoma in situ

Importance of microcalcifications in mammographic differentiation of the invasive ductal breast cancer and of the ductal carcinoma in situ

Retrospective analysis of pathologic nipple discharge

A Pathologists Purview of Breast Calcifications

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