Retrospective analysis of pathologic nipple discharge

Li, Yang; Wu, Di; Fan, Zhimin

doi:10.4238/2015.february.13.23

Cited by 7 publications

(4 citation statements)

References 9 publications

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“…The cause of pathologic nipple discharge is primarily benign lesions, but there is still a possibility of malignancy [16]. Pathologic nipple discharge patients with breast microcalcifications had a higher risk of breast cancer than those without breast calcifications ( p = 0.000) [17].…”

Section: Discussionmentioning

confidence: 99%

Does establishing a preoperative nomogram including ultrasonographic findings help predict the likelihood of malignancy in patients with microcalcifications?

Wang

Lai

et al. 2019

Cancer Imaging

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Background Mammography (MG) is highly sensitive for detecting microcalcifications, but has low specificity. This study investigates whether establishing a preoperative nomogram including ultrasonographic findings can help predict the likelihood of malignancy in patients with mammographic microcalcification. Methods Between May 2012 and January 2017, 475 patients with suspicious microcalcifications detected on MG underwent ultrasonography (US). The χ 2 test was used to screen risk factors among the variables. Then, a multivariate logistic regression analysis was performed to identify independent predictors of malignant microcalcifications. A mammographic nomogram (M nomogram) and mammographic-ultrasonographic nomogram (M-U nomogram) were established based on multivariate logistic regression models. The discriminatory ability and clinical utility of both nomograms were compared by the receiver operating characteristics curve and decision curve analysis. The calibration ability was evaluated using a calibration curve. Results Among the cases, 68.2% (324/475) were pathologically diagnosed as breast cancer and 31.8% (151/475) were benign lesions. Based on multivariate logistic regression analysis, age, clinical manifestation, morphology and distribution of microcalcifications on MG and lesions associated with microcalcifications on US were confirmed as independent predictors of malignant microcalcifications. In terms of discrimination ability, the C-index of the M-U nomogram was significantly higher than that of the M nomogram (0.917 vs 0.897, p = 0.006). The bias-corrected curve was close to the ideal line in the calibration curve. Decision curve analysis suggested that the M-U nomogram was superior to M nomogram. Conclusions Combining mammographic parameters with ultrasonographic findings in a nomogram provided better performance than an M nomogram alone, especially for dense breasts, which suggests the value of ultrasonographic finding for individualized prediction of malignancy in patients with microcalcifications.

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Section: Discussionmentioning

confidence: 99%

Does establishing a preoperative nomogram including ultrasonographic findings help predict the likelihood of malignancy in patients with microcalcifications?

Wang

Lai

et al. 2019

Cancer Imaging

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show abstract

“…Benign nipple discharge is most often bilateral, nonbloody, and nonspontaneous. 4 On the contrary, pathologic nipple discharge, as seen in this patient, is most often unilateral, bloody, and spontaneous. 4 Recent studies indicate that up to 25% of patients with pathologic nipple discharge will have underlying breast cancer.…”

Section: Discussionmentioning

confidence: 66%

“… 4 On the contrary, pathologic nipple discharge, as seen in this patient, is most often unilateral, bloody, and spontaneous. 4 Recent studies indicate that up to 25% of patients with pathologic nipple discharge will have underlying breast cancer. For patients with breast cancer presenting with only pathologic nipple discharge, mammography is of limited sensitivity (10% to 57%).…”

Section: Discussionmentioning

confidence: 66%

Breast carcinoma masquerading as basal cell carcinoma of the nipple

Moennich

Ort²,

High

et al. 2015

JAAD Case Reports

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“…Currently, there are no proven predictive models for malignancy in these patients. Surgical selective duct excision still remains the gold standard for treatment (3,5,12,13). In our study, 18% of all cases (60/344) were confirmed to have malignancy.…”

Section: Discussionmentioning

confidence: 99%