Mammary Neoplasia in Mice

Nandi, Satyabrata; McGrath, Charles M.

doi:10.1016/s0065-230x(08)60535-7

Cited by 315 publications

(191 citation statements)

References 145 publications

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“…For example, MMTV has been shown to be a natural etiologic agent of mammary tumors in M. musculus (26,27). By contrast, an endogenous type B virus isolated from guinea pigs is associated with a high incidence of leukemia rather than mammary adenocarcinoma (28,29).…”

Section: Methodsmentioning

confidence: 99%

A new class of genetically transmitted retravirus isolated from Mus cervicolor.

Callahan¹,

Benveniste²,

Sherr³

et al. 1976

Proc. Natl. Acad. Sci. U.S.A.

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Electron Microscopy. Tissues and cell pellets were fixed in 2.5% glutaraldehyde, rinsed with several changes of 0.01 M phosphate-buffered saline, treated with Dalton's chromeosmium, and rinsed again with several changes of distilled, deionized water (6). The specimens were stained overnight with 1% uranyl-acetate in 50% ethanol, dehydrated with increasing concentrations of ethanol, followed by propylene oxide, and embedded in Luft Epon. Thin sections were stained with lead citrate. Negative stains were prepared by mixing isopycnically banded virus in 0.05 M sodium citrate (pH 6.0) with 2% potassium phosphotungstate (pH 4.0). The mixture was deposited on a carbon-coated grid, drained, and air-dried just prior to use. Viral Polymerase Assays. Virus from culture supernatants was concentrated and assayed for viral reverse transcriptase as described (2, 3). Reactions were carried out in a total volume of 0.1 ml using 0.5 Ml of virus (10 Mig of protein) and contained 50 mM Tris-HCI (pH 7.8), 4 mM dithiothreitol, 60 mM KCI, 0.03% Triton X-100, and MnCl2 or MgCl2 as indicated. Po-

show abstract

Section: Methodsmentioning

confidence: 99%

A new class of genetically transmitted retravirus isolated from Mus cervicolor.

Callahan¹,

Benveniste²,

Sherr³

et al. 1976

Proc. Natl. Acad. Sci. U.S.A.

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show abstract

“…Mouse mammary tumour virus (MMTV) is associated with mammary carcinomas in susceptible mouse strains (Nandi & McGrath, 1973;Bentvelzen, 1974). The virus is transmitted exogenously as an infectious agent through the milk of infected mice from mother to offspring (Bittner, 1936) or through the germ line as endogenous proviral loci (Varmus et al, 1972;Groner & Hynes, 1980).…”

Section: Introductionmentioning

confidence: 99%

Factors controlling the expression of mouse mammary tumour virus

Günzburg

Salmons

1992

Biochemical Journal

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“…By now, it is well known that neoplasia in the mammary gland can be influenced by a variety of factors. Genetic, hormonal, viral, immunological, dietary and other environmental factors are involved in varying degrees in determining spontaneous mammary cancer in rodents (Nandi & McGrath, 1973).…”

Section: Induction Of Mammary-gland Tumours In Rats and Micementioning

confidence: 99%

Induction of mammary-gland tumours in rats and mice by hormones and chemical carcinogens

Hooson¹

1980

Br J Cancer

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Mammary Neoplasia in Mice

Cited by 315 publications

References 145 publications

A new class of genetically transmitted retravirus isolated from Mus cervicolor.

A new class of genetically transmitted retravirus isolated from Mus cervicolor.

Factors controlling the expression of mouse mammary tumour virus

Induction of mammary-gland tumours in rats and mice by hormones and chemical carcinogens

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