Mammary myofibroblastoma: Report of two cases with fine‐needle aspiration cytology and review of the cytology literature

Odashiro, Alexandre Nakao; Miiji, Luciana Nakao Odashiro; Odashiro, Danilo N.; Nguyen, Gia‐Khanh

doi:10.1002/dc.20042

Cited by 29 publications

(34 citation statements)

References 12 publications

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“…As expected, the collagenized variant showed smears with scarce cellularity and fibrous stroma and may resemble a solitary fibrous tumor. One of our cases corresponds to the cellular variant and showed findings similar to those reported previously [9,13]. This variant can be particularly problematic because of the prominent cellularity seen on cytology.…”

Section: Discussionsupporting

confidence: 87%

“…The recent report by Landeyro et al [15] describing MFB mentions the existence of intranuclear pseudoinclusions. This finding, originally reported by López-Rios et al [10] was questioned by others and interpreted as an artifact of air-dried material [13]. In 3 of our cases intranuclear pseudoinclusions were a relevant finding.…”

Section: Discussioncontrasting

confidence: 41%

“…Due to the rarity of MFB the role of cytology in its preoperative diagnosis is still not well established. Reflecting its rarity, few cytologic descriptions are available, and most of them consist of isolated cases [4,5,6,7,8,9,10,11,12,13,14,15]. In this report we describe 6 cases of mammary MFB in which fine-needle aspiration cytology (FNAC) was performed preoperatively.…”

Section: Introductionmentioning

confidence: 99%

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Fine-Needle Aspiration Cytology of Mammary Myofibroblastoma: A Report of Six Cases

Álvarez-Rodríguez

Gimeno-Aranguez²,

López-Varela³

et al. 2012

Acta Cytologica

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Objective: To evaluate cytologic features of mammary myofibroblastoma in order to establish the possibility of precise preoperative recognition. Study Design: This was a multi-institutional study of 6 patients with myofibroblastoma (5 men and 1 woman) in which preoperatively fine-needle aspiration cytology was performed. Four cases showed classical histologic features, 1 corresponded to the cellular variant and the remaining 1 to the fibrous form. Results: Except for 1 case, smears were cellular and distributed as irregular aggregates and single cells. Most groups showed a small amount of metachromatic stroma and capillaries. Cells retained cytoplasm and showed a spindle-to-plump oval morphology with moderate pleomorphism. Nuclear pleomorphism was present and was relevant in 1 case. Intranuclear pseudoinclusions and mast cells were present in 3 cases. No epithelial clusters were seen. Due to hypercellularity and pleomorphism 1 case was considered as suspicious for malignancy. The remaining 5 were diagnosed as low-grade mesenchymal lesions, and myofibroblastoma was suggested in 3. Conclusion: Cytologic features of myofibroblastoma reflect what is seen on histology. When such findings are correlated with image studies, preoperative recognition can be possible. This is especially true for male patients in whom the tumor is relatively frequent.

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Section: Discussionsupporting

confidence: 87%

Section: Discussioncontrasting

confidence: 41%

Section: Introductionmentioning

confidence: 99%

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Fine-Needle Aspiration Cytology of Mammary Myofibroblastoma: A Report of Six Cases

Álvarez-Rodríguez

Gimeno-Aranguez²,

López-Varela³

et al. 2012

Acta Cytologica

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“…The most frequently used was FNA (12 cases, 55%); in 3 (14%) cases, both FNA and CB were employed. The typical FNA pattern showed isolated spindle-shaped cells mixed with tissue fragments, mimicking other neoplastic and non-neoplastic breast conditions, such as fibromatosis, myofibroblastoma, inflammatory myofibroblastic tumor, benign fibrous histiocytoma, spindle cell lipoma, phyllodes tumor, metaplastic carcinoma, and sarcoma [22,26,27]. A surgical excision was often required to obtain the final diagnosis.…”

Section: Resultsmentioning

confidence: 99%

Breast Nodular Fasciitis: A Comprehensive Review

Paliogiannis¹,

Cossu²,

Palmieri³

et al. 2016

Breast Care

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Background: This article describes the demographic, clinical, pathological and prognostic features of breast nodular fasciitis through a comprehensive review of the cases reported in modern literature. Material and Methods: English-language articles published from January 1970 to October 2015 and related to breast nodular fasciitis were non-systematically retrieved using the PubMed database. Titles, abstracts and references were evaluated in order to include the most relevant studies. The demographic characteristics of the patients and the signs and symptoms of the disease were reviewed, as well as the results of the radiological and diagnostic procedures employed and of the treatments adopted. Results: 26 papers reporting on 28 cases were enrolled; however, manuscripts published before 1990 were excluded because of old methodologies, technologies and clinical approaches. Thus, 22 cases included in 20 papers were analyzed in detail. Conclusion: The rarity and the unspecific clinical and radiological characteristics of breast nodular fasciitis make the differential diagnosis and management challenging. Knowledge of the clinical, pathological and prognostic aspects of this condition is crucial for breast care specialists in order to improve their diagnostic and therapeutic interventions.

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“…The main histological characteristic that differentiates MFBs from the majority of malignant mesenchymal breast lesions is the presence of spindle cells in a collagenous background. Low mitotic activity and vimentin and CD34 positivity have been reported as well [3]. The aim of this investigation was to analyze all cases of breast MFB presented in our institution.…”

Section: Introductionmentioning

confidence: 99%

Myofibroblastoma of the Breast: Diagnostic Challenges of a Rare Benign Tumor

et al. 2013

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Breast myofibroblastomas (MFBs) are rare benign tumors that have recently been recognized as a distinct entity. They are more common in men and often coexist with gynecomastia. Fine needle aspiration cytology or core biopsy should always be performed for triple assessment; however, due to the multiple variants of the tumor, final diagnosis can be safely accomplished only postoperatively with the aid of immunohistochemistry. The main histological characteristic that differentiates MFBs from the majority of malignant mesenchymal breast lesions is the presence of spindle cells in a collagenous background. Low mitotic activity and vimentin and CD34 positivity have been reported as well. Surgical excision retains a pivotal diagnostic and curative role. Local resection is sufficient, but mastectomy can also be advocated either in cases of male patients with coexisting gynecomastia or in females with large tumors. Into this retrospective survey, three cases of breast MFB were consecutively enrolled. Two patients were postmenopausal females and one was male. Relevant literature is briefly reviewed. Clinical features, histogenesis, morphological, and immunochemical findings are discussed, while the role of the current diagnostic and therapeutic management of this uncommon neoplasm is emphasized.

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Mammary myofibroblastoma: Report of two cases with fine‐needle aspiration cytology and review of the cytology literature

Cited by 29 publications

References 12 publications

Fine-Needle Aspiration Cytology of Mammary Myofibroblastoma: A Report of Six Cases

Fine-Needle Aspiration Cytology of Mammary Myofibroblastoma: A Report of Six Cases

Breast Nodular Fasciitis: A Comprehensive Review

Myofibroblastoma of the Breast: Diagnostic Challenges of a Rare Benign Tumor

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