Mammary fibroadenomatoid hyperplasia in a heifer

Silva, Lorena Ferreira; Silva, Luiz Antônio Franco da; Rabelo, Rogério Elias; Silva, Wanessa Patrícia Rodrigues da; Cassali, Geovanni Dantas; Gonçalves, Aline Ferreira Lima; Sant’Ana, Fabiano José Ferreira de

doi:10.1590/0103-8478cr20160943

Cited by 2 publications

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References 16 publications

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“…Has been published a confirmed clinical case of fibroadenomatoid hyperplasia of the breast gland in a 12-month-old Holstein heifer. Clinical symptoms were demonstrated by dense multilobular foci in the right quarters of the udder, which was confirmed by the results of microscopy (hyperplasia of the mammary gland epithelium, numerous well-differentiated and moderately pleomorphic acini, moderate proliferation of myoepithelial cells and fibrous connective tissue) and immunohistochemical analysis (100 % showed immunoreactivity for p63, in 50 % -receptors for estrogen and progesterone, in 30 % -were positive for Ki-67 (Silva et al, 2017).…”

Section: Fibrocystic Disease In Various Species Of Animalsmentioning

confidence: 55%

Canine mastopathy (Overview)

Bilyi,

Khomutenko

2022

TAVM

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The etiological factors, pathogenesis and clinical and pathomorphological features of mastitis in dogs remain poorly understood, due to isolated, multidirectional studies on a small number of animals. Fibrocystic disease is diagnosed in different species of animals -small domestic, productive and laboratory animals. The clinical signs are not pathognomonic and an atypical course of the disease is possible. The potential role of mastopathy in the development of cancer has been proven, but the pathogenesis of functional dysplasia of mammary tissue, and the internal and external factors that may initiate further neoplastic transformation, remain poorly understood. Mastopathy in bitches is widespread and accounts for 8 to 30% of benign mammary gland neoplasms. Susceptibility varies considerably according to the distribution of breeds in the region. Compared to neoplasms (where the highest incidence is in animals over 7 years of age), mastitis peaks in 5-6-year-old dogs. A hormonal imbalance has been shown to be a direct cause of fibrocystic disease in bitches, and this has been experimentally confirmed in rats. The prognostic significance of estrogen and progesterone receptor expression was clarified. The importance of chronic inflammation in the pathogenesis of fibrocystic disease was shown. A high risk of mastopathy in overweight bitches has been established. Diabetes is a potential risk factor for fibrocystic disease, but further research is needed to clarify the patterns. The prospect for further research is to identify prognostic factors and key biological mechanisms to predict the course of the disease and to develop pathogenetically sound treatment protocols.

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Section: Fibrocystic Disease In Various Species Of Animalsmentioning

confidence: 55%

Canine mastopathy (Overview)

Bilyi,

Khomutenko

2022

TAVM

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“…However, FMFH has also been described in male cats and other species, such as cows and rats. [12][13][14][15][16][17] Ovariohysterectomy (OVH) has been documented to treat FMFH, but other therapeutic approaches have been adopted, including antiprogestin drugs or even mastectomy. 6,18,19 Nowadays, mastectomy should be avoided as antiprogestin drugs are often effective to treat FMFH, although treatment can take as long as 5 weeks and recurrence of FMFH after antiprogestin treatment has been reported.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of ovariohysterectomy on feline mammary fibroepithelial hyperplasia treatment

Melo

Câmara

Notomi

et al. 2020

Journal of Feline Medicine and Surgery

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Objectives The aim of this study was to evaluate the effectiveness of ovariohysterectomy (OVH) on feline mammary fibroepithelial hyperplasia (FMFH) treatment, as well as the influence of previous injectable progestin on clinical signs and treatment of FMFH. Methods Seventy-nine female cats diagnosed with FMFH between 2014 and 2018 were included. The animals were distributed as follows: (1) treated only with OVH (TA) or OVH plus antiprogestin (TB); and (2) no administration (G1) or previous administration (G2) of injectable progestin before FMFH diagnosis. Data regarding clinical signs of FMFH, occurrence of persistent mammary growth after OVH, and time until complete remission of FMFH post-surgery were recorded and evaluated. Results Mastectomy was not performed in any cat during the study. TA was adopted in 71/79 (89.9%) cases, with 42/71 (59.2%) from G2 and 29/71 (40.8%) from G1. TB was adopted in 8/79 (10.1%) cats, all from G2. Total remission of FMFH was observed in 73/79 (92.4%) cats, with six animals from G2 having died (n = 6/79 [7.6%]). The time until complete remission of FMFH was higher ( P <0.0001) in cats from G2 than from G1. Moreover, animals from G2 had a higher percentage of persistent mammary growth after OVH ( P <0.001) and a tendency to higher mortality ( P = 0.052) compared with G1. Conclusions and relevance Previous treatment with injectable progestin may result in a more complex clinical presentation of FMFH. Ovariohysterectomy is a good treatment option for FMFH when there is no interest in breeding the queen. Treatment with antiprogestin is recommended, especially if persistent mammary growth is detected after OVH.

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Mammary fibroadenomatoid hyperplasia in a heifer

Abstract: This manuscript described the anatomopathological and immunohistochemical findings in a rare

Cited by 2 publications

References 16 publications

Canine mastopathy (Overview)

Canine mastopathy (Overview)

Effectiveness of ovariohysterectomy on feline mammary fibroepithelial hyperplasia treatment

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