Mammary epithelial cell derived exosomal MiR-221 mediates M1 macrophage polarization via SOCS1/STATs to promote inflammatory response

Cai, Mingcheng; Shi, Yu; Zheng, Tianhao; Hu, Shiyan; Du, Kun; Ren, Anyong; Jia, Xianbo; Chen, Shiyi; Wang, Jie; Lai, Songjia

doi:10.1016/j.intimp.2020.106493

Cited by 29 publications

(21 citation statements)

References 38 publications

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“…mTORC1 loss and gain of function studies in macrophages resulted in amelioration and exacerbation of inflammatory response, as well as macrophage polarization to both M1 and M2 profiles ( 25 ). miR-221 mediates M1 macrophage polarization ( 26 , 27 ), while suppression of miR-222 alleviate the inflammatory response ( 28 , 29 ). However, we did not observe the apparent changes in gene expression of cytokines such as Il1b , Il6 , Ifng , and Tnf in adipose tissues in Mir221/222AdipoKO mice ( Supplementary Figure 2 ).…”

Section: Discussionmentioning

confidence: 99%

Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4

et al. 2022

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MicroRNAs expressed in adipocytes are involved in transcriptional regulation of target mRNAs in obesity, but miRNAs critically involved in this process is not well characterized. Here, we identified upregulation of miR-221-3p and miR-222-3p in the white adipose tissues in C57BL/6 mice fed with high fat-high sucrose (HFHS) chow by RNA sequencing. Mir221 and Mir222 are paralogous genes and share the common seed sequence and Mir221/222AdipoKO mice fed with HFHS chow demonstrated resistance to the development of obesity compared with Mir221/222flox/y. Ddit4 is a direct target of Mir221 and Mir222, and the upregulation of Ddit4 in Mir221/222AdipoKO was associated with the suppression of TSC2 (tuberous sclerosis complex 2)/mammalian target of rapamycin complex 1 (mTORC1)/S6K (ribosomal protein S6 kinase) pathway. The overexpression of miR-222-3p linked to enhanced adipogenesis, and it may be a potential candidate for miRNA-based therapy.

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Section: Discussionmentioning

confidence: 99%

Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4

et al. 2022

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“…The activated STAT3 enters the nucleus and induces the expression of IL-6, LOX and other genes, thus promoting tumorigenesis. 33,34…”

Section: Exosomes—the Key Messenger In the Breast Cancer Microenviron...mentioning

confidence: 99%

Exosome-based delivery nanoplatforms: next-generation theranostic platforms for breast cancer

Zheng

Weng

et al. 2022

Biomater. Sci.

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“…Therefore, the inhibition of IL-10-STAT3 is one of the molecular mechanisms by which hypoxia promotes inflammation through macrophages [ 119 ]. Studies have confirmed that exosomes derived from breast epithelial cells tend to regulate the activation of M1 macrophages by enhancing the expression of miR-221, which is mainly accomplished by inhibiting the SOCS1 cascade and regulating STAT1 and STAT3 [ 120 ]. In addition, exosomes containing miR-3 promote the polarization of M1 macrophages, and enhance the secretion of IL-6 by inhibiting the JAK/STAT signaling pathway [ 121 ].…”

Section: Relationship Between Ev-mirna and Inflammation Under Hypoxiamentioning

confidence: 99%

MicroRNA in extracellular vesicles regulates inflammation through macrophages under hypoxia

Tan

Miao

et al. 2021

Cell Death Discov.

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Extracellular vesicle (EV), critical mediators of cell-cell communication, allow cells to exchange proteins, lipids, and genetic material and therefore profoundly affect the general homeostasis. A hypoxic environment can affect the biogenesis and secrete of EVs, and the cargoes carried can participate in a variety of physiological and pathological processes. In hypoxia-induced inflammation, microRNA(miRNA) in EV participates in transcriptional regulation through various pathways to promote or reduce the inflammatory response. Meanwhile, as an important factor of immune response, the polarization of macrophages is closely linked to miRNAs, which will eventually affect the inflammatory state. In this review, we outline the possible molecular mechanism of EV changes under hypoxia, focusing on the signaling pathways of several microRNAs involved in inflammation regulation and describing the process and mechanism of EV-miRNAs regulating macrophage polarization in hypoxic diseases.

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Mammary epithelial cell derived exosomal MiR-221 mediates M1 macrophage polarization via SOCS1/STATs to promote inflammatory response

Cited by 29 publications

References 38 publications

Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4

Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4

Exosome-based delivery nanoplatforms: next-generation theranostic platforms for breast cancer

MicroRNA in extracellular vesicles regulates inflammation through macrophages under hypoxia

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