Mammary analog secretory carcinoma of minor palatal salivary glands: A case report and review of the literature

Helkamaa, Tessa; Rossi, S.; Mesimäki, Karri; Suomalainen, Anni; Tarkkanen, Jussi; Leivo, Ilmo; Skálová, Alena; Hagström, Jaana

doi:10.1016/j.ajoms.2015.02.005

Cited by 11 publications

(6 citation statements)

References 19 publications

(25 reference statements)

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“…From then on, revisiting the medical literature, retrospective studies, and case reports were integrated to scout the incidence of MASC SG . This systematic review surveys almost all the reported cases, after omitting the repeated cases, in order to define our nosology about MASC SG . In 2013, Sethi et al concluded that MASC SG was claimed to be encountered in men more than in women.…”

Section: Introductionmentioning

confidence: 99%

Systematic review of mammary analog secretory carcinoma of salivary glands at 7 years after description

Khalele

2017

Head & Neck

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The available data about MASC is sufficient enough to diagnose it with no need to investigate the ETV6-NTRK3 translocation. Although high-grade malignancy and distant metastases were rarely reported, a rapt attention should be paid both to the nature of this tumor and to the indicated close follow-up of such cases, especially when necrosis, increased mitotic activity, and other classic caveats are conspicuous. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1243-1248, 2017.

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Section: Introductionmentioning

confidence: 99%

Systematic review of mammary analog secretory carcinoma of salivary glands at 7 years after description

Khalele

2017

Head & Neck

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“…Sixty-eight cases of minor salivary gland-originated SC have been reported between 2010 and 2017 [4,7–11,18–43] . These cases were identified in a literature search conducted using keywords such as “mammary analogue secretory carcinoma,” “secretory carcinoma”, “oral cavity”, “buccal mucosa,” “lip,” “palate,” “gingiva,” and “tongue” in PubMed and the Japan Medical Abstracts Society databases.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and treatment of secretory carcinoma arising from the oral minor salivary gland

et al. 2021

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Introduction: Secretory carcinoma (SC) is a malignancy of the salivary glands, which is similar to SC of the breast regarding its association with neurotrophic tyrosine receptor kinase fusion-positive gene. SC is a recently described salivary gland tumor, and there are a few reports describing oral minor salivary gland-derived SC. We reported two cases of SC in the oral cavity and reviewed the literature. Patient concerns: The patients included a 65-year-old Japanese woman who presented with a mass of the upper lip and an 84-year-old Japanese man who presented with a mass on the buccal mucosa. Diagnosis: Diagnosis was based on histomorphological and immunohistochemical findings and identification of a specific translocation of the ETS variant 6-neurotrophic receptor tyrosine kinase 3 gene fusion. Case 1 was finally diagnosed using reverse transcription-polymerase chain reaction with formalin-fixed paraffin-embedded tissue samples, while case 2 was diagnosed using fluorescence in situ hybridization analysis. Interventions and outcomes: In case 1, excisional biopsy was done and there was no recurrence observed in five-year follow-up. In case 2, tumor resection was done and there was no recurrence observed in two-year follow-up. Conclusion: It is highly likely for many cases of SC to be initially diagnosed as acinic cell carcinoma (AciCC) owing to their similar histological findings. The treatment strategy for minor salivary gland-originated SC is similar to that of AciCC; however, SC is often highly malignant and involves a high risk of cervical lymph node metastasis. Thus, establishing an accurate diagnosis together with pathologists and confirming the presence of the ETS variant 6-neurotrophic receptor tyrosine kinase 3 fusion gene using genetic analysis is important.

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“…The only aggressive tumor was in hard palate which showed slow growth for 36 months but was aggressive for 2 months [23]. Two patients with tumor at hard palate complained of pain with ulceration [15, 22]. Lymph node metastases occurred in only 4 patients [2, 6, 23, 28] and local recurrence was reported in 4 patients [7, 23, 28].…”

Section: Discussionmentioning

confidence: 99%

Secretory Carcinoma of Minor Salivary Gland in Buccal Mucosa: A Case Report and Review of the Literature

Paudel

Nishimura

Adhikari

et al. 2019

Case Reports in Pathology

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Secretory carcinoma (SC) of the salivary gland was recently added to the fourth edition of the World Health Organization classification of head and neck tumors. Some salivary tumors, including acinic cell carcinoma, have been reclassified as SC. Most of these tumors are located on the parotid gland with very few cases reported in the minor salivary glands of the buccal mucosa. Herein, we present a case of SC of buccal mucosa, which appeared clinically as a benign lesion in a 54-year-old Japanese female patient. Histopathologically, the tumor cells presented with an eosinophilic cytoplasm with microcytic structure along with eosinophilic secretory material and hemosiderin deposit. Immunohistochemical staining revealed strongly positive staining for S100, vimentin, and mammaglobin and negative staining for DOG-1. The tumor was finally diagnosed as secretory carcinoma of the buccal mucosa. We present a review of the medical literature of SC arising from minor salivary glands. We found only 15 cases of SC of buccal mucosa out of 63 cases of SC in the minor salivary glands. They showed good prognoses and only one case of SC in the buccal mucosa exhibited local recurrence and lymph node metastases.

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Mammary analog secretory carcinoma of minor palatal salivary glands: A case report and review of the literature

Cited by 11 publications

References 19 publications

Systematic review of mammary analog secretory carcinoma of salivary glands at 7 years after description

Systematic review of mammary analog secretory carcinoma of salivary glands at 7 years after description

Diagnosis and treatment of secretory carcinoma arising from the oral minor salivary gland

Secretory Carcinoma of Minor Salivary Gland in Buccal Mucosa: A Case Report and Review of the Literature

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