Diagnosis and treatment of secretory carcinoma arising from the oral minor salivary gland

Abstract

Introduction: Secretory carcinoma (SC) is a malignancy of the salivary glands, which is similar to SC of the breast regarding its association with neurotrophic tyrosine receptor kinase fusion-positive gene. SC is a recently described salivary gland tumor, and there are a few reports describing oral minor salivary gland-derived SC. We reported two cases of SC in the oral cavity and reviewed the literature. Patient concerns: The patients included a 65-year-old Japanese woman who presented with a mass of the upper lip and an 84-year-old Japanese man who presented with a mass on the buccal mucosa. Diagnosis: Diagnosis was based on histomorphological and immunohistochemical findings and identification of a specific translocation of the ETS variant 6-neurotrophic receptor tyrosine kinase 3 gene fusion. Case 1 was finally diagnosed using reverse transcription-polymerase chain reaction with formalin-fixed paraffin-embedded tissue samples, while case 2 was diagnosed using fluorescence in situ hybridization analysis. Interventions and outcomes: In case 1, excisional biopsy was done and there was no recurrence observed in five-year follow-up. In case 2, tumor resection was done and there was no recurrence observed in two-year follow-up. Conclusion: It is highly likely for many cases of SC to be initially diagnosed as acinic cell carcinoma (AciCC) owing to their similar histological findings. The treatment strategy for minor salivary gland-originated SC is similar to that of AciCC; however, SC is often highly malignant and involves a high risk of cervical lymph node metastasis. Thus, establishing an accurate diagnosis together with pathologists and confirming the presence of the ETS variant 6-neurotrophic receptor tyrosine kinase 3 fusion gene using genetic analysis is important.

Salivary Gland Secretory Carcinoma; Review of 13 Years World‐Wide Experience and Meta‐Analysis

“…Out of a total of 226 studies published between 2010 and 2023, identified at initial search and screened for retrieval, 112 1–3,6–114 articles were included in the study, with a total of 674 patients described in these articles. The identification and screening process is described in Figure 1.…”

Submandibular Secretory Carcinoma in a 10-year-old Filipino

“…Thus, clinical stage and high-grade transformation are the main adverse prognostic factors in which establishing an accurate histopathologic diagnosis, confirming the ETV6-NTRK3 fusion gene by genetic analysis is important both for diagnostic and prognostic purposes. [15][16][17] Currently, the guidelines for surgical treatment, chemoradiation, and follow up of these cases have not been standardized due to the small number of cases. 1) and negative immunostaining for Thyroglobulin, TTF1, DOG1, and CD117.…”