Mammalian DNA methylation and a nuclear S‐adenosyl L‐methionine‐dependent nuclease activity

The transmethylation and one-carbon cycle hypotheses of schizophrenia

“…Transmethylation of lipids has been shown to be an essential step in many membrane reactions, including coupling of adrenergic and other receptors to adenylate cyclase, histamine release by immunoglobulin E antigens, nerve growth factor responses and others (Strittmatter et al 1979). Transmethylation of histones, DNA and RNA play an important role in gene expression, DNA repair, mutation, DNA replication and recombination (Doerfler, 1981;Cato & Burdon, 1979). Thus, a defect in methylation even at the kinetic level might have widespread effects on brain and behaviour.…”