Methylation of reiterated sequences in mammalian DNAs Effects of the tissue type, age, malignancy and hormonal induction

Romanov, G. A.; Vanyushin, B. F.

doi:10.1016/0005-2787(81)90156-8

Cited by 131 publications

(56 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Romanov and Vanyushin found that the thymus and heart tissue from cows experienced a decline in 5mC content with age. 49 Genomic hypomethylation in various organs has also been observed in rats 50 and mice. 51 A study making use of pyrosequencing probed 217 nonpathologic human tissues from 10 anatomic sites, and analyzed DNA methylation of 1,413 autosomal CpG loci associated with 773 genes in both young and old subjects.…”

Section: Dna Hypomethylation and Hypermethylationmentioning

confidence: 95%

The Role of DNA Methylation in Aging, Rejuvenation, and Age-Related Disease

Johnson

Akman²,

Calimport³

et al. 2012

Rejuvenation Research

318

218

View full text Add to dashboard Cite

DNA methylation is a major control program that modulates gene expression in a plethora of organisms. Gene silencing through methylation occurs through the activity of DNA methyltransferases, enzymes that transfer a methyl group from S-adenosyl-l-methionine to the carbon 5 position of cytosine. DNA methylation patterns are established by the de novo DNA methyltransferases (DNMTs) DNMT3A and DNMT3B and are subsequently maintained by DNMT1. Aging and age-related diseases include defined changes in 5-methylcytosine content and are generally characterized by genome-wide hypomethylation and promoter-specific hypermethylation. These changes in the epigenetic landscape represent potential disease biomarkers and are thought to contribute to age-related pathologies, such as cancer, osteoarthritis, and neurodegeneration. Some diseases, such as a hereditary form of sensory neuropathy accompanied by dementia, are directly caused by methylomic changes. Epigenetic modifications, however, are reversible and are therefore a prime target for therapeutic intervention. Numerous drugs that specifically target DNMTs are being tested in ongoing clinical trials for a variety of cancers, and data from finished trials demonstrate that some, such as 5-azacytidine, may even be superior to standard care. DNMTs, demethylases, and associated partners are dynamically shaping the methylome and demonstrate great promise with regard to rejuvenation.

show abstract

Section: Dna Hypomethylation and Hypermethylationmentioning

confidence: 95%

The Role of DNA Methylation in Aging, Rejuvenation, and Age-Related Disease

Johnson

Akman²,

Calimport³

et al. 2012

Rejuvenation Research

318

218

View full text Add to dashboard Cite

show abstract

“…In mammals, there is an age-associated decline in total genomic DNA methylation [26][27][28]. This occurs mostly at repetitive DNA sequences, and so probably occurs predominantly in domains of constitutive heterochromatin.…”

Section: Aging Is Associated With Epigenetic Changes From Yeast To Hmentioning

confidence: 99%

Aging by epigenetics—A consequence of chromatin damage?

Sedivy

Gowrishankar

Adams

2008

Experimental Cell Research

140

102

View full text Add to dashboard Cite

Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. In some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-deterministic changes in chromatin structure might, over time, also contribute to the break down of nuclear, cell and tissue function, and consequently aging and age-associated diseases.

show abstract

“…In eukaryotes the modified base 5-mC (C*) occurs predominantly in the sequence 5'-C*pG-3' (Dosko~il & ~orm, 1962;Grippo et al, 1968), but 5-mC has also been found in 5'-C*pC-3' (Salomon & Kaye, 1970;Sneider, 1980;Gruenbaum et al, 1981;Romanov & Vanyushin, 1981) and 5'-C*pT-3' sequences (Salomon & Kaye, 1970;Sneider, 1972). The degree of methylation of C in these sequences varies greatly depending on many parameters, such as species, type of gene and stage of development.…”

Section: On the Biochemistry Of Dna Methylationmentioning

confidence: 99%