Mammaglobin in peripheral blood and tumor in breast cancer patients

Боженко, В К; Харченко, Н В; Васкевич, Е. Ф.; Кудинова, Е А; Ооржак, А В; Ni, Rozhkova; Троценко, И Д

doi:10.18097/pbmc20166204453

Cited by 3 publications

(4 citation statements)

References 10 publications

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“…The marker MGB is a member of the secretoglobin family of proteins, with a predicted molecular weight of 10 kD as cloned from breast cancer epithelial cells (6). The protein has been suggested as a tumor-associated marker for the diagnosis of breast carcinoma (7). Positive expression of GCDFP-15 and MGB in breast carcinomas is 50% and 75%, respectively; but their sensitivity remains poor, particularly in high-grade breast cancer such as triplenegative breast carcinoma (4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological significance of Sox10 expression in triple-negative breast carcinoma

Jin¹,

Qin²,

Qi³

et al. 2020

Transl Cancer Res TCR

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This study aimed to investigate the SRY-related higll-mobility-group box 10 (Sox10) expression in the pathological diagnosis of triple-negative breast cancer (TNBC). Furthermore, its correlation with the clinicopathological characteristics and disease-free survival rate in patients with TNBC was also evaluated to identify the diagnostic utility of Sox10 as a reliable biomarker for the diagnosis and prognosis of TNBC.Methods: Using immunohistochemistry (IHC), we identified the expression of Sox10, GATA binding protein 3 (GATA-3), forkhead box protein A1 (FOXA1), gross cystic disease fluid protein (GCDFP15), and mammaglobin (MGB) in 376 cases of primary invasive breast cancer, and 77 cases of metastatic breast cancer.The expression of Sox10 in different molecular subtypes of primary invasive breast cancer and metastatic breast cancer were also compared. Furthermore, the correlation between Sox10 expression and clinicopathological parameters and disease-free survival (DFS) of patients with primary TNBC were also analyzed.Results: Expression of Sox10 was only detected in the myoepithelial cells of normal breast tissue, but not in any other types of cells, including luminal cells and fibroblasts. The positive rate of Sox10 in primary and metastatic TNBC was significantly higher than that in luminal types and human epidermal growth factor receptor 2 (HER2) overexpressed type. The sensitivity and specificity of Sox10 expression in primary TNBC and metastatic TNBC were significantly lower than GATA-3, significantly higher than FOXA1, GCDFP15, and MGB (P<0.001, P=0.0004, P=0.0064, P=0.0229, respectively). In 71 cases of primary TNBC, a higher expression rate of Sox10 was significantly associated with high-grade tumors, late-stage tumors, and tumors with involvement of four or more lymph node metastases (P=0.0145, P=0.0105, P=0.0249, respectively).Conclusions: Sox10 may be used as a novel reliable putative marker for the diagnosis of TNBC. Notably, Sox10 combined with GATA-3 expression may serve as a supplementary differential diagnostic biomarker for primary and metastatic TNBC. Besides, Sox10 may be a good predictor of the prognosis of primary and metastatic TNBC. This study also highlights the significance of targeting Sox10 as a promising potential therapeutic target gene for TNBC therapy.

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Section: Introductionmentioning

confidence: 99%

“…The protein has been suggested as a tumor-associated marker for the diagnosis of breast carcinoma ( 7 ). Positive expression of GCDFP-15 and MGB in breast carcinomas is 50% and 75%, respectively; but their sensitivity remains poor, particularly in high-grade breast cancer such as triple-negative breast carcinoma ( 4 - 7 ).…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological significance of Sox10 expression in triple-negative breast carcinoma

Jin¹,

Qin²,

Qi³

et al. 2020

Transl Cancer Res TCR

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“…The expressions obtained from cfDNA originate from tumor cells that detach from a tumor at an advanced stage of its development. 154 In 29 articles, [23][24][25]28,59,60,68,73,79,80,85,89,92,95,96,99,103,105,108,109,115,117,119,121,126,128,129,136,141 sensitivity and specificity were reported individually for a single biomarker. In 21 of these, sensitivity was greater than 70%.…”

Section: Discussionmentioning

confidence: 99%

Cancer Biomarkers in Liquid Biopsy for Early Detection of Breast Cancer: A Systematic Review

Duque

Manterola

Otzen

et al. 2022

Clin Med Insights Oncol

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Background: Breast cancer (BC) is the most common neoplasm in women worldwide. Liquid biopsy (LB) is a non-invasive diagnostic technique that allows the analysis of biomarkers in different body fluids, particularly in peripheral blood and also in urine, saliva, nipple discharge, volatile respiratory fluids, nasal secretions, breast milk, and tears. The objective was to analyze the available evidence related to the use of biomarkers obtained by LB for the early diagnosis of BC. Methods: Articles related to the use of biomarkers for the early diagnosis of BC due to LB, published between 2010 and 2022, from the databases (WoS, EMBASE, PubMed, and SCOPUS) were included. The MInCir diagnostic scale was applied in the articles to determine their methodological quality (MQ). Descriptive statistics were used, as well as determination of weighted averages of each variable, to analyze the extracted data. Sensitivity, specificity, and area under the curve values for specific biomarkers (individual or in panels) are described. Results: In this systematic review (SR), 136 articles met the selection criteria, representing 17 709 patients with BC. However, 95.6% were case-control studies. In 96.3% of cases, LB was performed in peripheral blood samples. Most of the articles were based on microRNA (miRNA) analysis. The mean MQ score was 25/45 points. Sensitivity, specificity, and area under the curve values for specific biomarkers (individual or in panels) have been found. Conclusions: The determination of biomarkers through LB is a useful mechanism for the diagnosis of BC. The analysis of miRNA in peripheral blood is the most studied methodology. Our results indicate that LB has a high sensitivity and specificity for the diagnosis of BC, especially in early stages.

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“…It is reported that expression of hMAG is mostly related to breast carcinoma tissue, and hMAG is defined as one of the first relatively mammary-specific markers (13). There are many studies in literature that are related to mammaglobin level of the peripheral blood in BC patients, while there are not so many studies describing mammagilobin level in cancer tissue; studies concerning mammaglobin level of peritumoral tissue are really rare (22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

Mammaglobin expression in tissue as a predictor of breast carcinoma aggressiveness

et al. 2021

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Introduction: Human mammaglobin is considered to be one of the most significant markers of hematogenous dissemination of breast carcinoma. Our goal is to indicate the important role of peritumoral tissue as an active participant in the tumorrogenesis process and the concentration / expression of mamaglobins in the peritumoral tissue as a significant prognostic factor. Materials and methods: This research included 64 patients with primary breast carcinoma during five-year follow-up period. To determine the concentration of mamaglobin A in samples of carcinoma tissue and peritumoral tissue, ELISA essay was used, and for the determination of relative gene expression of Mammaglobin A, qRT-PCR was used. Results: The concentration of mamaglobin A increases in both the carcinoma tissue and peritumoral tissue with an increase in tumor size, number of affected lymph nodes, number of metastases, while relative expression of Mamaglobin A is statistically significantly higher in carcinoma tissue than in peritumoral tissue, regardless of tumor size, number of affected lymph nodes, number of metastases and tumor type. The concentration of mamaglobin A is higher in peritumor tissue than in tissue of ductal carcinoma, while in the case of lobular carcinoma the concentration of mamaglobin A is higher in carcinoma tissue than in peritumor tissue. Conclusion: Mammaglobin A concentration in peritumoral tissue higher than 0,6704221 ng/ml, and in carcinoma tissue higher than 0,5784426 ng/ml, as well as Mammaglobin A relative gene expression in carcinoma tissue higher than 1.003 were determined as cutoff values that may identify patients who are at higher risk of metastatic disease, which would be treated with early radical adjuvant treatment.

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Mammaglobin in peripheral blood and tumor in breast cancer patients

Cited by 3 publications

References 10 publications

Clinicopathological significance of Sox10 expression in triple-negative breast carcinoma

Clinicopathological significance of Sox10 expression in triple-negative breast carcinoma

Cancer Biomarkers in Liquid Biopsy for Early Detection of Breast Cancer: A Systematic Review

Mammaglobin expression in tissue as a predictor of breast carcinoma aggressiveness

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