Mamíferos como reservatórios de Trypanosoma sp. – Uma abordagem bibliométrica

Silva, Joselaine Souto Hall; Silva, Dionei José da; Malheiros, Antônio Francisco

doi:10.33448/rsd-v10i7.16539

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…Several articles and reviews describe the distribution of T. cruzi DTUs in wild reservoirs. References of such studies can be found in recent reviews [9,[105][106][107].…”

Section: Association Of the Dtus With Mammalian Reservoirsmentioning

confidence: 99%

Fifteen Years after the Definition of Trypanosoma cruzi DTUs: What Have We Learned?

Zingales,

Macedo

2023

Life

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Trypanosoma cruzi, the protozoan causative of Chagas disease (ChD), exhibits striking genetic and phenotypic intraspecific diversity, along with ecoepidemiological complexity. Human-pathogen interactions lead to distinct clinical presentations of ChD. In 2009, an international consensus classified T. cruzi strains into six discrete typing units (DTUs), TcI to TcVI, later including TcBat, and proposed reproducible genotyping schemes for DTU identification. This article aims to review the impact of classifying T. cruzi strains into DTUs on our understanding of biological, ecoepidemiological, and pathogenic aspects of T. cruzi. We will explore the likely origin of DTUs and the intrinsic characteristics of each group of strains concerning genome organization, genomics, and susceptibility to drugs used in ChD treatment. We will also provide an overview of the association of DTUs with mammalian reservoirs, and summarize the geographic distribution, and the clinical implications, of prevalent specific DTUs in ChD patients. Throughout this review, we will emphasize the crucial roles of both parasite and human genetics in defining ChD pathogenesis and chemotherapy outcome.

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“…Several articles and reviews describe the distribution of T. cruzi DTUs in wild reservoirs. References of such studies can be found in recent reviews [9,[105][106][107].…”

Section: Association Of the Dtus With Mammalian Reservoirsmentioning

confidence: 99%

Fifteen Years after the Definition of Trypanosoma cruzi DTUs: What Have We Learned?

Zingales,

Macedo

2023

Life

View full text Add to dashboard Cite

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Fifteen Years after the Definition of <em>Trypanosoma cruzi </em>DTUs: What Have We Learned?

Zingales,

Macedo

2023

Preprint

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Trypanosoma cruzi, the protozoan causative of Chagas disease (ChD), exhibits striking genetic and phenotypic intraspecific diversity, along with ecoepidemiological complexity. Human-pathogen interactions lead to distinct clinical presentations of ChD. In 2009, an international consensus classified T. cruzi strains into six discrete typing units (DTUs), TcI to TcVI, later including TcBat, and proposed reproducible genotyping schemes for DTU identification. This article aims to review the impact of classifying T. cruzi strains into DTUs on our understanding of biological, ecoepidemio-logical, and pathogenic aspects of T. cruzi. We will explore the likely origin of DTUs and the intrinsic characteristics of each group of strains concerning genome organization, genomics, and suscepti-bility to drugs used in ChD treatment. We will also provide an overview of the association of DTUs with mammalian reservoirs, and summarize the geographic distribution, and the clinical implica-tions, of prevalent specific DTUs in ChD patients. Throughout this review, we will emphasize the crucial roles of both parasite and human genetics in defining ChD pathogenesis and chemotherapy outcome.

show abstract

Mamíferos como reservatórios de Trypanosoma sp. – Uma abordagem bibliométrica

Cited by 2 publications

References 28 publications

Fifteen Years after the Definition of Trypanosoma cruzi DTUs: What Have We Learned?

Fifteen Years after the Definition of Trypanosoma cruzi DTUs: What Have We Learned?

Fifteen Years after the Definition of <em>Trypanosoma cruzi </em>DTUs: What Have We Learned?

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