Malt Lymphoma of the Colon: a Rare Occurrence

Ramavaram, Samyuktha; Velchala, Neelima; Levy, Rebecca; Rego, Rayburn

doi:10.1007/s12029-013-9526-2

Cited by 3 publications

(4 citation statements)

References 17 publications

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“…The mean age of presentation is 60 years. Although female predominance is seen in a 2: 1 ratio compared to males in some studies, there is no difference among the genders according to one review [11,16–18]. …”

Section: Discussionmentioning

confidence: 99%

Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma of the Colon: A Case Report and a Literature Review

2017

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Patient: Female, 56Final Diagnosis: Colonic MALT lymphomaSymptoms: Epigastric painMedication: —Clinical Procedure: Colonoscopy and biopsySpecialty: Gastroenterology and HepatologyObjective:Rare diseaseBackground:Non-Hodgkin lymphoma (NHL) is a well-known hematologic malignancy. The gastrointestinal (GI) tract is the most commonly involved extra nodal site. MALT lymphomas are uncommon, accounting for 5% of all NHL. Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is the prototype seen in association with Helicobacter pylori. Colonic MALT lymphoma is rare and comprises only 2.5% of the MALT lymphomas. Its etiology and treatment is not well established.Case Report:A 56-year-old Hispanic woman presented to the clinic with symptoms of chronic epigastric pain for the past three years and a 13-pound weight loss over the past two months. The patient did not have any prior medical conditions. Her systemic examination was unremarkable, while her routine labs revealed mild anemia. An upper endoscopy and colonoscopy for colorectal cancer screening were performed revealing erosive gastropathy with duodenal ulcers and a 5 cm broad based polypoid mass in the hepatic flexure respectively. Computed tomography (CT) of the abdomen revealed a round, well demarcated mass at the hepatic flexure of the colon. The histopathology and immunophenotyping were consistent with extra nodal marginal zone of MALT lymphoma. Stool testing for H. pylori was positive. The patient received two weeks of H. pylori eradication therapy and four cycles of rituximab. Repeat colonoscopy after completion of chemotherapy showed complete resolution of the MALT lymphoma.Conclusions:Unlike gastric MALT lymphoma, treatment of colonic MALT lymphoma is not standardized. Chemotherapy and surgical resection have been utilized to successfully treat it. Only a handful of cases have reported successful treatment of colonic MALT lymphoma with rituximab monotherapy.

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Section: Discussionmentioning

confidence: 99%

Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma of the Colon: A Case Report and a Literature Review

2017

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“…2 In that study, more than half MALT lymphomas were found in the stomach, whereas only 10%-20% of cases were found in the small bowel or colon.…”

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confidence: 78%

“…However, although this may be true of gastric MALT lymphomas, this may not be true of lymphomas found in the colon. 1,2 Other bacteria with which these lymphomas may be associated include Borrelia afzelii, Campylobacter jejuni, Chlamydia psittaci, and various Mycobacteria. 3 Additionally, MALT lymphomas may be associated with genetic aberrancies including multiple translocations and trisomy 3, or several autoimmune conditions including rheumatoid arthritis, Hashimoto thyroiditis, systemic lupus erythematosis, and others.…”

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confidence: 99%

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An Unusually Located Colonic Mass

2016

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Synchronous MALT lymphoma of the colon and stomach and regression after eradication ofStrongyloides stercoralisandHelicobacter pylori

2018

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Mucosa-associated lymphoid tissue (MALT) is vital for host immunological surveillance against pathogens. MALT lymphoma, also known as extranodal marginal zone B cell lymphoma, is a non-Hodgkin's lymphoma subtype that predominantly arises in the gastrointestinal tract. Chronic infection is a common cause of gastric MALT lymphoma, although other infections are reported in association with extragastric MALT lymphomas. To our knowledge, here we report the first case of synchronous MALT lymphomas of the colon and stomach in the presence of and infections that resolved after eradication of both organisms.

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Malt Lymphoma of the Colon: a Rare Occurrence

Cited by 3 publications

References 17 publications

Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma of the Colon: A Case Report and a Literature Review

Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma of the Colon: A Case Report and a Literature Review

An Unusually Located Colonic Mass

Synchronous MALT lymphoma of the colon and stomach and regression after eradication ofStrongyloides stercoralisandHelicobacter pylori

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