Emphysematous gastritis is a rare and lethal gastrointestinal emergency if not promptly identified and managed. In rare cases, emphysematous gastritis is associated with Sarcina ventriculi infection, usually in patients with delayed gastric emptying. Here we report a lethal case of S. ventriculi-associated emphysematous gastritis in the absence of delayed gastric emptying in which the diagnosis was confirmed postmortem. This case provides an opportunity to review the clinical presentation, pathophysiology, and management of emphysematous gastritis so that the condition can be promptly diagnosed and managed to prevent significant morbidity and mortality.
Background: Intracellular trafficking of RGS proteins is an important determinant of their function as G-protein inhibitors. Results: Amino-terminal cysteine residues in RGS4 confer previously uncharacterized localization and trafficking activities. Conclusion: Cys-12 is required for plasma membrane targeting, whereas Cys-2 is required for localization to endosomal pools. Significance: Understanding the mechanisms governing cellular distribution of RGS4 may lead to novel strategies for regulation of its function.
Recent studies investigating the relationship between self-reported sexual desire and attraction to same- and opposite-sex individuals have found that homosexual men's sexual desire is positively correlated with their self-reported attraction to own-sex individuals only, while homosexual women's sexual desire is positively correlated with their self-reported attraction to both men and women. These data have been interpreted as evidence that sexual desire strengthens men's pre-existing (i.e., dominant) sexual behaviors and strengthens women's sexual behaviors in general. Here we show that homosexual men's (n = 106) scores on the Sexual Desire Inventory-2 (SDI-2) were positively correlated with their preferences for exaggerated sex-typical shape cues in own-sex, but not opposite-sex, faces. Contrary to the hypothesis that sexual desire strengthens women's preferences for sexual dimorphism generally, homosexual women's (n = 83) SDI-2 scores were positively correlated with their preferences for exaggerated sex-typical shape cues in opposite-sex faces only. Together with previous research in heterosexual subjects, our findings support the proposal that sexual desire increases the incidence of existing sexual behaviors in homosexual and heterosexual men, and increases the incidence of sexual responses more generally in heterosexual women, although not necessarily in homosexual women.
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