MALT lymphoma of the colon: a clinicopathological review

Abstract

<jats:p>Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) occurs in approximately 9% of non-Hodgkin B cell lymphoma. However, it occurs only rarely within the colon. The presentation is often asymptomatic, and can have multiple endoscopic appearances, including a single or multinodular polypoid lesion. Furthermore, small biopsies can make histological evaluation challenging. The 2016 WHO classification update includes many molecular features of entities and expands the differential diagnosis of lymphoid lesions of the colon. In addition to immunohistochemistry, molecular methods may be tempting to use for small difficult cases. Furthermore, treatment approaches are varied for this entity, and not well studied. Therefore, an updated review on MALT lymphoma of the colon is needed.</jats:p>

An unexpected cause of iron deficiency

“…Although the prevalence of GI MALT lymphoma is on the rise, involvement of the colorectum is rare in comparison with other sites (<1%). [2][3][4] Typically colonic MALT lymphoma affects patients in the fifth to seventh decade of life, with approximately 50% diagnosed on screening endoscopy. 5 As in our case, there are reports of colonic MALT lymphoma presenting with weight loss and mild anaemia in the absence of B symptoms.…”

Successful Endoscopic Resection of Residual Colonic Mucosa-Associated Lymphoid Tissue Lymphoma after Polypectomy

“…3 Although the stomach is the most frequent site of involvement, MALT lymphoma can occur in various organs, including the lungs, lacrimal gland, salivary glands, and thyroid. 3 Among the gastrointestinal tract, colorectal MALT lymphoma is rarely found. 3 As most gastric MALT lymphomas are closely related to…”

“…3 Among the gastrointestinal tract, colorectal MALT lymphoma is rarely found. 3 As most gastric MALT lymphomas are closely related to…”

“…Since first described by Isaacson and Wright in 1983 [ 1 ], mucosa-associated lymphoid tissue (MALT) lymphoma was classified as extranodal marginal zone B-cell lymphoma of the MALT type by the World Health Organization in 2008 [ 2 ]. MALT lymphoma accounts for approximately 9% of non-Hodgkin lymphomas [ 3 ]. Although the stomach is the most frequent site of involvement, MALT lymphoma can occur in various organs, including the lungs, lacrimal gland, salivary glands, and thyroid [ 3 ].…”

“…MALT lymphoma accounts for approximately 9% of non-Hodgkin lymphomas [ 3 ]. Although the stomach is the most frequent site of involvement, MALT lymphoma can occur in various organs, including the lungs, lacrimal gland, salivary glands, and thyroid [ 3 ]. Among the gastrointestinal tract, colorectal MALT lymphoma is rarely found [ 3 ].…”