Malondialdehyde epitopes as mediators of sterile inflammation

Busch, Clara Jana-Lui; Binder, Christoph J.

doi:10.1016/j.bbalip.2016.06.016

Cited by 93 publications

(77 citation statements)

References 115 publications

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“…This result confirmed the reports that RSV is a potential therapeutic intervention for aging- or oxidative stress-associated disorder [34]. MDA is one of the end-products of lipid peroxidation [35] and it is also a mediator of sterile inflammation [36]. For carrageenan-induced acute air-pouch synovitis test (Figure 3), there were no significant differences on the contents of MDA and the T-SOD activities between the treated (DXM and RSV) groups and control group ( P > 0.05), but significant differences were detected when compared with the negative control group.…”

Section: Resultssupporting

confidence: 89%

Analgesic and Anti‐Inflammatory Activities of Resveratrol through Classic Models in Mice and Rats

Wang

Song

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Background. Inflammation and pain are closely related to humans' and animals' health. Resveratrol (RSV) is a natural compound with various biological activities. The current study is aimed to evaluate the analgesic and anti-inflammatory activities of RSV in vivo. Materials and Methods. The analgesic effects were assessed by the acetic acid-induced writhing and hot plate tests. The anti-inflammatory effects were determined using the xylene-induced mouse ear oedema, the acetic acid-induced rat pleurisy, and carrageenan-induced rat synovitis tests, respectively. Results. The analgesic results showed that RSV could significantly inhibit the number of writhes and improve the time and pain threshold of mice standing on hot plate. The anti-inflammatory results showed that RSV could inhibit the ear oedema of mice. In acetic acid-induced pleurisy test, RSV could significantly inhibit the WBC and pleurisy exudates, could decrease the production of NO, and elevate the activity of SOD in serum. In carrageenan-induced synovitis test, RSV could reduce the content of MDA and elevate the T-SOD activity in serum; RSV could inhibit the expressions of TP, PGE2, NO, and MDA. Conclusion. Shortly, these results indicated that RSV had potent analgesic and anti-inflammatory activities and could be a potential new drug candidate for the treatment of inflammation and pain.

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Section: Resultssupporting

confidence: 89%

Analgesic and Anti‐Inflammatory Activities of Resveratrol through Classic Models in Mice and Rats

Wang

Song

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…Importantly, the miR-592 level has also been reported to decrease after cerebral ischemia, and miR-592 overexpression decreases ischemic injuries in neurons [34]. In several inflammatory pathologies, MDA epitopes function as biomarkers of oxidative stress [35], while SOD, a primary protective agent, can release oxidative stress mediators and activate inflammatory mediators [36]. Global hypoxia-ischemia results in extensive cerebral inflammation [37].…”

Section: Discussionmentioning

confidence: 99%

Effects of MicroRNA-592-5p on Hippocampal Neuron Injury Following Hypoxic-Ischemic Brain Damage in Neonatal Mice - Involvement of PGD2/DP and PTGDR

Sun

Guo

Zhang

et al. 2018

Cell Physiol Biochem

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Background/Aims: This study aimed to explore the effect of microRNA-592-5p (miR-592-5p) on hypoxic-ischemic brain damage (HIBD)-induced hippocampal neuronal injury in a neonatal mouse model relative to the involvement of one target gene, PTGDR, and the PGD2/ DP signaling pathway. Methods: A total of 30 neonatal mice aged 7 days were randomly selected to establish an HIBD mouse model. Hippocampal neuronal cells were transfected into a control group, a blank group, a negative control (NC) group, an miR-592-5p mimics group, an miR-592-5p inhibitors group, an siRNA-PTGDR group and an miR-592-5p inhibitors + siRNA-PTGDR group. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and Western blot analyses were performed to detect the expression levels of miR-592-5p, PTGDR, DP2, Bcl-2 and Bax in tissues and cells. Cell proliferation, cell cycle and apoptosis were detected by MTT assay and flow cytometry, respectively. Results: The expression levels of miR-592-5p and Bcl-2 decreased, while the expression levels of PTGDR, DP2 and Bax increased in the HIBD group. PTGDR is a target gene of miR-592-2p. Compared with the NC and blank groups, the expression levels of PTGDR, DP2 and Bax decreased, while the expression levels of miR-592-5p and Bcl-2 increased in the miR-592-5p mimics group. The siRNA-PTGDR group showed the same trend as that observed in the miR-592-5p mimics group, except with no difference in miR-592-5p expression. The miR-592-5p inhibitors group showed an opposite gene expression trend compared to that in the miR-592-5p mimics group. The S phase of the cell cycle was prolonged, the G1 phase was reduced, proliferation was increased, and the apoptosis rate was decreased in the siRNA-PTGDR and miR-592-5p mimics groups. Opposite trends for cell cycle, proliferation and apoptosis were observed in the miR-592-5p inhibitors group. Conclusions: Our study suggests that miR-592-5p upregulation protects against hippocampal neuronal injury caused by HIBD by targeting PTGDR and inhibiting the PGD2/DP signaling pathway.

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“…As recently reviewed [73], MDA and its derivatives are proinflammatory and are involved in the pathogenesis of age-related macular degeneration (AMD), atherosclerosis, lung inflammation and liver fibrosis, among other pathologies. MDA gives rise to more complex lipid motifs, such as a highly reactive and immunogenic 4-methyl-1,4-dihydropyridine-3,5-dicarbaldehyde, also termed malondialdehyde-acetaldehyde (MAA).…”

Section: Inflammatory Effects Of Lipid Oxidation End Productsmentioning

confidence: 99%

“…MDA gives rise to more complex lipid motifs, such as a highly reactive and immunogenic 4-methyl-1,4-dihydropyridine-3,5-dicarbaldehyde, also termed malondialdehyde-acetaldehyde (MAA). As oxidation-produced DAMPs, MDA epitopes are recognized by multiple arcs of innate immunity, including the scavenger receptor SR-A1, the Fcγ receptor CD16, complement factors H and C3a, stabilin-1, and a number of natural antibodies [73–77]. Immunization of mice with MAA-modified LDL was atheroprotective [78].…”

Section: Inflammatory Effects Of Lipid Oxidation End Productsmentioning

confidence: 99%

Context-Dependent Role of Oxidized Lipids and Lipoproteins in Inflammation

Miller

Shyy

2017

Trends in Endocrinology & Metabolism

103

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Oxidized low-density lipoprotein (OxLDL), which contains hundreds of different oxidized lipid molecules, is a hallmark of hyperlipidemia and atherosclerosis. The same oxidized lipids found in OxLDL are also formed in apoptotic cells, and are present in tissues as well as in the circulation under pathological conditions. In many disease contexts, oxidized lipids constitute damage signals, or patterns, that activate pattern-recognition receptors and significantly contribute to inflammation. This article reviews recent discoveries and emerging trends in the field of oxidized lipids and regulation of inflammation, focusing on oxidation products of polyunsaturated fatty acids esterified into cholesteryl esters and phospholipids. The paper highlights context-dependent activation and biased agonism of TLR4 and the NLRP3 inflammasome, among other signaling pathways activated by oxidized lipids.

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Malondialdehyde epitopes as mediators of sterile inflammation

Cited by 93 publications

References 115 publications

Analgesic and Anti‐Inflammatory Activities of Resveratrol through Classic Models in Mice and Rats

Analgesic and Anti‐Inflammatory Activities of Resveratrol through Classic Models in Mice and Rats

Effects of MicroRNA-592-5p on Hippocampal Neuron Injury Following Hypoxic-Ischemic Brain Damage in Neonatal Mice - Involvement of PGD2/DP and PTGDR

Context-Dependent Role of Oxidized Lipids and Lipoproteins in Inflammation

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