Analgesic and Anti‐Inflammatory Activities of Resveratrol through Classic Models in Mice and Rats

Abstract

Background. Inflammation and pain are closely related to humans' and animals' health. Resveratrol (RSV) is a natural compound with various biological activities. The current study is aimed to evaluate the analgesic and anti-inflammatory activities of RSV in vivo. Materials and Methods. The analgesic effects were assessed by the acetic acid-induced writhing and hot plate tests. The anti-inflammatory effects were determined using the xylene-induced mouse ear oedema, the acetic acid-induced rat pleurisy, and carrageenan-induced rat synovitis tests, respectively. Results. The analgesic results showed that RSV could significantly inhibit the number of writhes and improve the time and pain threshold of mice standing on hot plate. The anti-inflammatory results showed that RSV could inhibit the ear oedema of mice. In acetic acid-induced pleurisy test, RSV could significantly inhibit the WBC and pleurisy exudates, could decrease the production of NO, and elevate the activity of SOD in serum. In carrageenan-induced synovitis test, RSV could reduce the content of MDA and elevate the T-SOD activity in serum; RSV could inhibit the expressions of TP, PGE2, NO, and MDA. Conclusion. Shortly, these results indicated that RSV had potent analgesic and anti-inflammatory activities and could be a potential new drug candidate for the treatment of inflammation and pain.

Clinical efficacy of resveratrol as an adjuvant with meloxican in the treatment of knee osteoarthritis patients: A double-blind, randomised, placebo-controlled trial

“…In the present study, 90 days of resveratrol use resulted in a significant improvement in the clinical scores of OA pain and disability in participants with knee OA. These clinical observations are in line with the available data showing that resveratrol reduces pain, inflammation, and oedema, as well as articular destruction in experimental models of arthritis (Wang, Chen, Wang, 2016;Wang et al, 2017). Together with the previously reported data, the present finding supports the analgesic activity of dietary polyphenols in patients with mild-tomoderate knee pain, and suggests that it is in tune with the results of many pilot studies reported regarding the adjuvant use of polyphenols and other supplements during the treatment of inflammatory musculoskeletal disorders like knee OA and rheumatoid arthritis (Hussain et al, 2009;Hussain et al, 2016).…”

“…Together with the previously reported data, the present finding supports the analgesic activity of dietary polyphenols in patients with mild-tomoderate knee pain, and suggests that it is in tune with the results of many pilot studies reported regarding the adjuvant use of polyphenols and other supplements during the treatment of inflammatory musculoskeletal disorders like knee OA and rheumatoid arthritis (Hussain et al, 2009;Hussain et al, 2016). Although the exact mechanism behind the impact of resveratrol on improving OA symptoms in a clinical setting has not been well described, a series of animal experiments conducted in the past few years has demonstrated that the oral administration of resveratrol is capable of significantly preventing the progression of osteoarthritis (Gu et al, 2016), and also exhibits a potent analgesic effect in different animal models (Wang et al, 2017;Bazzo et al, 2013). Despite the large output of preclinical studies dealing with the analgesic and antiinflammatory activities of resveratrol, there is a relative lack of clinical trials investigating the analgesic effect of resveratrol (Nguyen et al, 2017;Vang et al, 2011).…”

Protective Effects of Resveratrol Supplementation on Contusion Induced Muscle Injury

“…RES is a natural compound with multiple biological activities. A previous study reported that RES could inhibit various pain and inflammation conditions and able to exert a treatment effect with analgesic and anti-inflammatory activities [30]. Exercise-induced muscle damage (EIMD) can cause pain and affect daily activities, such as reduced range of motion, stiffness and swelling [31].…”

Efficacy and safety of co-administration of resveratrol with meloxicam in patients with knee osteoarthritis: a pilot interventional study

“…8 , 9 It has been widely reported that resveratrol has anti-proliferative, anti-oxidative, anti-inflammatory, and analgesic effects in many experimental models. 10 – 14 Preclinical studies provided accumulating evidence on its efficacy in ameliorating the degenerative articular damage that mostly attributed to its pleiotropic properties. 15 , 16 Moreover, many pieces of evidence have displayed resveratrol as one of the nutraceutical candidates for OA therapy in human.…”