Clinical efficacy of resveratrol as an adjuvant with meloxican in the treatment of knee osteoarthritis patients: A double-blind, randomised, placebo-controlled trial

Marouf, Bushra Hassan; Hussain, Saad Abdulrahman; Ali, Ziyad Serdar; Ahmmad, Runj Simko

doi:10.1590/s2175-97902018000417773

Cited by 5 publications

(7 citation statements)

References 40 publications

(35 reference statements)

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“…Two recent clinical studies confirmed the involvement of resveratrol in managing knee OA pain and its associated symptoms [ 51 , 67 ]. Supplementation of 500 mg/day resveratrol led to increased aggrecan serum levels and significantly improved pain, although no significant decrease in serum levels of IL-6, IL-1β, and TNF- α was observed [ 56 ].…”

Section: Efficacy and Mechanism Of Action Of Polyphenolsmentioning

confidence: 94%

“…This nutraceutical has many health-benefiting properties, including its anti-inflammatory, antioxidant, and anticancer properties. By modulating major oxidative stress signaling pathways, resveratrol has become one of the most studied nutraceuticals in managing degenerative diseases such as OA [ 51 , 52 , 54 , 55 , 56 , 57 , 67 ] ( Table 1 ).…”

Section: Efficacy and Mechanism Of Action Of Polyphenolsmentioning

confidence: 99%

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Effect of Dietary Polyphenols on Osteoarthritis—Molecular Mechanisms

Sirše

2022

Life

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Osteoarthritis is a common crippling and degenerative disease resulting in irreversible functional changes due to damage of the cartilage and other tissues of the joint. With limited safe and effective pharmaceutical treatments, the demand and use for alternative therapeutic approaches with symptomatic relief for OA patients have increased. Clinical, pre-clinical, and in vitro studies have demonstrated that polyphenols can exert pain-relieving symptoms coupled with increased functional capacity in OA models. This review will highlight studies carried out in the last five years to define the efficacies and underlying mechanisms in polyphenols such as quercetin, resveratrol, curcumin, epigallocatechin-3-gallate, rosmarinic acid, genistein, ginger, berries, silver fir, pine bark, and Boswellia. Most of these studies indicate that polyphenols exhibit their beneficial roles through regulating changes at the biochemical and molecular levels, inducing or inhibiting various signaling pathways related to inflammation and oxidative stress. Polyphenols have also been implicated in modulating microRNA at the posttranscriptional level to counteract OA pathogenesis.

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Section: Efficacy and Mechanism Of Action Of Polyphenolsmentioning

confidence: 94%

Section: Efficacy and Mechanism Of Action Of Polyphenolsmentioning

confidence: 99%

Effect of Dietary Polyphenols on Osteoarthritis—Molecular Mechanisms

Sirše

2022

Life

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“…Additionally, KOOS subscales for functional and activity status were also dramatically improved. The significant clinical improvement in the symptoms and stiffness was predicted because antinociceptive and anti-inflammatory effects of resveratrol can be obtained even within short-term treatment as reported by our previous reports and pilot interventional study on the efficacy of coadministration of resveratrol with meloxicam in patients with knee osteoarthritis [ 29 , 30 ]. Additionally, other studies demonstrated weak or no significant correlations between aggrecan levels and any of the relevant clinical presentations of OA such as morning stiffness, knee pain, local knee warmth, and other symptoms expressed by Lequesne functional index and Western Ontario and McMaster Universities Arthritis Index (WOMAC) score.…”

Section: Discussionmentioning

confidence: 89%

Effect of Resveratrol on Serum Levels of Type II Collagen and Aggrecan in Patients with Knee Osteoarthritis: A Pilot Clinical Study

Marouf¹

2021

BioMed Research International

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Treatment of knee osteoarthritis (OA) remains a challenging concern. Preclinical studies provided accumulating evidence on resveratrol efficacy in ameliorating degenerative articular damage. The present study was conducted to evaluate the effects of resveratrol as monotherapy on the serum level of type II collagen (Coll 2-1) and aggrecan in patients with knee osteoarthritis. The study was an open-labeled noncontrolled clinical trial. Resveratrol 500 mg/day in a single oral dose was given to the patients with knee osteoarthritis for 90 days. The serum levels of Coll-2-1, aggrecan, and biomarkers of inflammation were measured pre- and posttreatment. Hematological profiles and both hepatic and renal function markers were investigated at the baseline and at the end of the treatment for evaluating the tolerability and safety of resveratrol. Visual Analog Scale (VAS) for pain and Knee injury and Osteoarthritis Outcome Score (KOOS) for disease activity were clinically assessed monthly. Administration of 500 mg resveratrol for three months led to a nonsignificant decrease in the serum level of Coll 2-1 while a significant increase in aggrecan serum level. Resveratrol significantly improves pain score measured by VAS and KOOS after 30 days. Improvements in patients’ activity and functional status were also evident at day 30 and kept on for three months which was reflected by KOOS subscale scores and with a significant improvement in all KOOS areas. In conclusion, oral administration of resveratrol as a monotherapy provides a remarkable improvement in the clinical status of the patients but has no significant effect on serum levels of Coll 2-1.

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“…It was pointed out that the dosage used or the therapy duration should be reconsidered and the severity of the impairment might not be able to be improved by resveratrol. In the treatment of knee osteoarthritis, intervention of resveratrol as an adjuvant of meloxicam, daily intake of resveratrol (500 mg) combined with meloxicam could significantly improve pain and symptom scores in the mild-to-moderate knee osteoarthritis patient after a 90-day treatment . Surprisingly, as demonstrated by the same group of the research team, intervention of resveratrol had led to a secondary outcome, including reducing serum cholesterol, triglyceride, urea, and creatinine .…”

Section: Clinical Studies With Supplementation Of Stilbenoidsmentioning

confidence: 97%

“…In the treatment of knee osteoarthritis, intervention of resveratrol as an adjuvant of meloxicam, daily intake of resveratrol (500 mg) combined with meloxicam could significantly improve pain and symptom scores in the mild-to-moderate knee osteoarthritis patient after a 90day treatment. 141 Surprisingly, as demonstrated by the same group of the research team, intervention of resveratrol had led to a secondary outcome, including reducing serum cholesterol, triglyceride, urea, and creatinine. 142 In some cases, resveratrol showed no effect on the outcome expected, but it could be due to several possible reasons to be considered in future studies.…”

Section: Clinical Studies With Supplementation Of Stilbenoidsmentioning

confidence: 98%

Recent Advances in Health Benefits of Stilbenoids

Koh

Pan

2021

J. Agric. Food Chem.

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Biological targeting or molecular targeting is the main strategy in drug development and disease prevention. However, the problem of “off-targets” cannot be neglected. Naturally derived drugs are preferred over synthetic compounds in pharmaceutical markets, and the main goals are high effectiveness, lower cost, and fewer side effects. Single-target drug binding may be the major cause of failure, as the pathogenesis of diseases is predominantly multifactorial. Naturally derived drugs are advantageous because they are expected to have multitarget effects, but not off-targets, in disease prevention or therapeutic actions. The capability of phytochemicals to modulate molecular signals in numerous diseases has been widely discussed. Among them, stilbenoids, especially resveratrol, have been well-studied, along with their potential molecular targets, including AMPK, Sirt1, NF-κB, PKC, Nrf2, and PPARs. The analogues of resveratrol, pterostilbene, and hydroxylated-pterostilbene may have similar, if not more, potential biological targeting effects compared with their original counterpart. Furthermore, new targets that have been discussed in recent studies are reviewed in this paper.

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Clinical efficacy of resveratrol as an adjuvant with meloxican in the treatment of knee osteoarthritis patients: A double-blind, randomised, placebo-controlled trial

Abstract: The present study aimed to evaluate the effect of the adjuvant use of resveratrol with meloxicam on the clinical scores of knee OA patients. This was a double-blind placebo-controlled randomised trial involving 100 patients with knee osteoarthritis performed at the

Cited by 5 publications

References 40 publications

Effect of Dietary Polyphenols on Osteoarthritis—Molecular Mechanisms

Effect of Dietary Polyphenols on Osteoarthritis—Molecular Mechanisms

Effect of Resveratrol on Serum Levels of Type II Collagen and Aggrecan in Patients with Knee Osteoarthritis: A Pilot Clinical Study

Recent Advances in Health Benefits of Stilbenoids

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