Malnutrition in rheumatoid arthritis

Collins, R.; Dunn, Thaddeus L.; Walthaw, J.; Harrell, Pamela B.; Alarcón, G S

doi:10.1007/bf02206838

Cited by 20 publications

(8 citation statements)

References 29 publications

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“…Moreover, RA imposes a heavy financial burden on patients (3). The prevalence of malnutrition in RA patients in previous relevant studies is high, which prevalence of malnutrition was more than two-thirds (7,8). The high incidence of malnutrition in RA patients may be attributed to several factors.…”

Section: Discussionmentioning

confidence: 90%

Impact of the malnutrition on mortality in Rheumatoid arthritis patients: A cohort study from NHANES 1999–2014

Tian

Xiong

et al. 2023

Front. Nutr.

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BackgroundPatients with Rheumatoid arthritis (RA) are prone to malnutrition. However, it is rare studies assessing the relationship between malnutrition and all-cause mortality in patients with RA.ObjectiveTo investigate the relationship between malnutrition and all-cause mortality in patients with RA in a large national sample cohort.MethodsWe analyzed data on 1,976 adults ≥ 18 years of age during National Health and Nutrition Examination Survey (NHANES) 1999–2014. We chose the Controlled Nutritional Status Score (CONUT) and the Nutritional Risk Index (NRI) to assess the nutritional status of patients with RA. The Kaplan–Meier (KM) survival curves Cox proportional hazards regression models were used to analyze the associations between malnutrition and all-cause mortality.ResultsOf the 1,976 patients with RA (57.38 ± 0.40 years, female 59.9%, non-Hispanic white 69.9%), the prevalence of malnutrition was 18.8% by used the CONUT and 26.6% by used the NRI. The KM survival curves showed that malnutrition was associated with a higher incidence of all-cause mortality during the 10-year follow-up period (log-rank test, P < 0.001). In the fully corrected model, the adjusting hazard ratio (aHR) for all-cause mortality in patients with moderate to severe malnutrition with CONUT and NRI were 5.63 (95% CI, 2.55–12.45; P < 0.001) and 2.56 (95% CI, 1.81–3.62; P < 0.001), respectively, compared with patients without malnutrition.ConclusionMalnutrition is very prevalent in patients with RA, approximately 18.8% (CONUT) to 26.6% (NRI). Malnutrition is strongly associated with an increased risk of all-cause mortality. These findings underscore the importance of attention and intervention in the nutritional status of patients with RA. Further clinical trials are needed to prospectively assess the effect of nutritional interventions on the prognosis of patients with RA.

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Section: Discussionmentioning

confidence: 90%

Impact of the malnutrition on mortality in Rheumatoid arthritis patients: A cohort study from NHANES 1999–2014

Tian

Xiong

et al. 2023

Front. Nutr.

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“…Conversely, the lower absolute intake of energy, protein, carbohydrates and various other nutrients in women with 2 SS=RA may be related to several factors. For example, the severity of the joint inflammation in RA may limit the ability to self-feed (TougerDecker, 1988), thereby leading to a relative malnutrition in this disorder (Helliwell et al, 1984;Collins et al, 1987;van de Laar et al, 1990;Hansen et al, 1998). In addition, some patients with RA may modify their diets, or fast for periods of time, in order to reduce pain (Diethelm, 1993).…”

Section: Discussionmentioning

confidence: 99%

Nutrient intake in women with primary and secondary Sjögren's syndrome

et al. 2003

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“…The corollary of this finding is that measurement of serum albumin should not be used as a marker for underlying malnutrition. Malnutrition may occur in other chronic diseases, such as inflammatory bowel disease [66][67][68], rheumatoid arthritis [69][70][71][72][73][74][75][76], or chronic obstructive pulmonary disease [77][78][79][80][81]. Although we fear that physicians may rely on serum albumin to determine whether malnutrition is present, our data in SSc suggest that, as in other conditions, such as anorexia nervosa [34], elderly age [39], and end-stage renal disease [37,82,83], serum albumin may be well within the normal range in patients at high risk for malnutrition.…”

Section: Serum Albumin In Sclerodermamentioning

confidence: 99%